Authors:
A Miremadi, MZ Oestergaard, PDP Pharoah, C Caldas
Journal name: 
Hum Mol Genet
Citation info: 
16 Spec No 1:R28-R49
Abstract: 
The cancer epigenome is characterised by specific DNA methylation and chromatin modification patterns. The proteins that mediate these changes are encoded by the epigenetics genes here defined as: DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBD) proteins, histone acetyltransferases (HAT), histone deacetylases (HDAC), histone methyltransferases (HMT) and histone demethylases. We review the evidence that these genes can be targeted by mutations and expression changes in human cancers.
DOI: 
http://doi.org/10.1093/hmg/ddm021
Research group: 
Caldas Group
E-pub date: 
15 Apr 2007