Authors:
M Narita, ARJ Young, M Narita
Journal name: 
Autophagy
Citation info: 
5(7):1046-1047
Abstract: 
Oncogenic stress triggers a range of intracellular protective responses including DNA damage checkpoints, senescence and apoptosis, depending on the cell type and the severity of the particular stress. Senescent cells are metabolically viable but are stably arrested. Senescence is a collective phenotype, however, that is comprised of various signaling pathways and effector mechanisms. Thus, to understand and manipulate the senescence phenotype, it is critical to find its effector mechanisms and determine the relationships between them. We have recently found that autophagy is activated upon acute induction of senescence and facilitates another effector mechanism: the senescence associated secretory phenotype (SASP).
DOI: 
http://doi.org/10.4161/auto.5.7.9444
Research group: 
Narita Group
E-pub date: 
01 Oct 2009
Users with this publication listed: 
Andrew Young
Masako Narita
Masashi Narita