Authors:
R Ardekani, S Tavaré, J Tower
Journal name: 
Methods Mol Biol
Citation info: 
965:501-516
Abstract: 
Senescence is associated with changes in gene expression, including the upregulation of stress response- and innate immune response-related genes. In addition, aging animals exhibit characteristic changes in movement behaviors including decreased gait speed and a deterioration in sleep/wake rhythms. Here, we describe methods for tracking Drosophila melanogaster movements in 3D with simultaneous quantification of fluorescent transgenic reporters. This approach allows for the assessment of correlations between behavior, aging, and gene expression as well as for the quantification of biomarkers of aging.
DOI: 
http://doi.org/10.1007/978-1-62703-239-1_33
Research group: 
Tavaré Group
E-pub date: 
31 Aug 2013