Authors:
G Murphy, TE Cawston, JJ Reynolds
Journal name: 
Biochem J
Citation info: 
195(1):167-170
Abstract: 
1. An inhibitor of collagenase of apparent mol.wt. 28000 was isolated from term human amniotic fluid. 2. It is active against mammalian collagenases from a number of species and tissues as well as other mammalian metalloproteinases, but has no activity against bacterial metalloproteinases. 3. Activity is destroyed by treatment with either trypsin or 4-aminophenylmercuric acetate, by heat, and by reduction and carboxymethylation. 4. All the properties observed suggest that it is similar to the synthesized tissue inhibitor of metalloproteinases.
DOI: 
http://doi.org/10.1042/bj1950167
E-pub date: 
31 Mar 1981
Users with this publication listed: 
Gillian Murphy