Authors:
GM Doody, PW Dempsey, DT Fearon
Journal name: 
Curr Opin Immunol
Citation info: 
8(3):378-382
Abstract: 
Three accessory membrane proteins, CD19, CD22 and Fc gamma RIIb1, alter signaling through membrane immunoglobulin of B cells by binding cytosolic proteins containing SH2 domains. Recent biochemical and genetic studies have shown that these receptors enable B cells to amplify responses to certain T-cell-dependent antigens (CD19), to restrict their response to T-cell zones of secondary lymphoid organs (CD22), and to dampen their response to antigens for which IgG is already available (Fc gamma RIIb1).
DOI: 
http://doi.org/10.1016/s0952-7915(96)80128-2
E-pub date: 
01 Jun 1996
Users with this publication listed: 
Doug Fearon