Authors:
DJ Waterhouse, CRM Fitzpatrick, BW Pogue, JPB O'Connor, SE Bohndiek
Journal name: 
Nat Biomed Eng
Abstract: 
Clinical workflows for the non-invasive detection and characterization of disease states could benefit from optical-imaging biomarkers. In this Perspective, we discuss opportunities and challenges towards the clinical implementation of optical-imaging biomarkers for the early detection of cancer by analysing two case studies: the assessment of skin lesions in primary care, and the surveillance of patients with Barrett's oesophagus in specialist care. We stress the importance of technical and biological validations and clinical-utility assessments, and the need to address implementation bottlenecks. In addition, we define a translational roadmap for the widespread clinical implementation of optical-imaging technologies.
DOI: 
http://doi.org/10.1038/s41551-019-0392-5
Research group: 
VISION Lab
E-pub date: 
31 Mar 2019
Users with this publication listed: 
Dale Waterhouse
Sarah Bohndiek