Authors:
AA Neves, AS Krishnan, MI Kettunen, D-E Hu, MMD Backer, B Davletov, KM Brindle
Journal name: 
Nano Lett
Citation info: 
7(5):1419-1423
Abstract: 
A 110 kDa (ca. 5 nm in diameter) bivalent paramagnetic nanoprobe for detecting cell death using magnetic resonance imaging (MRI) is described, in which two biotinylated C2A domains of the protein synaptotagmin-I were complexed with a single avidin molecule, which had been labeled with gadolinium chelates. This nanoprobe bound with high affinity and specificity to the phosphatidylserine exposed by dying cells and was demonstrated to allow MRI detection of apoptotic tumor cells in vitro.
DOI: 
http://doi.org/10.1021/nl070126v
Research group: 
Brindle Group
E-pub date: 
31 May 2007