Authors:
D Kawauchi, G Robinson, T Uziel, P Gibson, J Rehg, C Gao, D Finkelstein, C Qu, S Pounds, DW Ellison, RJ Gilbertson, MF Roussel
Journal name: 
Cancer Cell
Citation info: 
21(2):168-180
Abstract: 
Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastoma. We generated a mouse model of MYC-subgroup medulloblastoma by transducing Trp53-null cerebellar progenitor cells with Myc. The cardinal features of these mouse medulloblastomas closely mimic those of human MYC-subgroup tumors and significantly differ from mouse models of the Sonic-Hedgehog- and WNT-disease subgroups. This mouse model should significantly accelerate understanding and treatment of the most aggressive form of medulloblastoma and infers distinct roles for MYC and MYCN in tumorigenesis.
DOI: 
http://doi.org/10.1016/j.ccr.2011.12.023
Research group: 
Gilbertson Group
E-pub date: 
14 Feb 2012