Authors:
M Bachman, S Uribe-Lewis, X Yang, HE Burgess, M Iurlaro, W Reik, A Murrell, S Balasubramanian
Journal name: 
Nat Chem Biol
Citation info: 
11(8):555-557
Abstract: 
5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC can be a stable DNA modification. These results suggest that 5fC has functional roles in DNA that go beyond being a demethylation intermediate.
DOI: 
http://doi.org/10.1038/nchembio.1848
Research group: 
Balasubramanian Group
E-pub date: 
31 Aug 2015