Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer.

Authors: M Ponz-Sarvise, V Corbo, H Tiriac, DD Engle, KK Frese, TE Oni, C-I Hwang, D...
Research group: Jodrell Group
E-pub date: 31 Aug 2019
Journal name: Clin Cancer Res

Quantifying drug-induced bone marrow toxicity using a novel haematopoiesis systems pharmacology model.

Authors: C Fornari, LO O'Connor, C Pin, A Smith, JWT Yates, SY Amy Cheung, DI Jodrel...
Research group: Jodrell Group
E-pub date: 31 Aug 2019
Journal name: CPT Pharmacometrics Syst Pharmacol

Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.

Authors: S Spencer, S Köstel Bal, W Egner, H Lango Allen, SI Raza, CA Ma, M Gürel,...
Research group: Jodrell Group, Tavaré Group
E-pub date: 31 May 2019
Journal name: J Exp Med

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites.

Authors: MS Patzak, V Kari, S Patil, FH Hamdan, RG Goetze, M Brunner, J Gaedcke, J K...
Research group: Jodrell Group
E-pub date: 31 Dec 2018
Journal name: EBioMedicine

The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression.

Authors: Y Wallez, CR Dunlop, TI Johnson, S-B Koh, C Fornari, JWT Yates, S Bernaldo ...
Research group: Jodrell Group
E-pub date: 11 Jun 2018
Journal name: Mol Cancer Ther

Mechanistic Distinctions between CHK1 and WEE1 Inhibition Guide the Scheduling of Triple Therapy with Gemcitabine.

Authors: S-B Koh, Y Wallez, CR Dunlop, S Bernaldo de Quirós Fernández, TE Bapiro, ...
Research group: Jodrell Group
E-pub date: 1 Jun 2018
Journal name: Cancer Res

CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype.

Authors: JB Candido, JP Morton, P Bailey, AD Campbell, SA Karim, T Jamieson, L Lapie...
Research group: Jodrell Group
E-pub date: 1 May 2018
Journal name: Cell Rep

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.

Authors: E Hessmann, MS Patzak, L Klein, N Chen, V Kari, I Ramu, TE Bapiro, KK Frese...
Research group: Jodrell Group
E-pub date: 31 Mar 2018
Journal name: Gut

Understanding Hematological Toxicities Using Mathematical Modeling.

Authors: C Fornari, LO O'Connor, JWT Yates, SYA Cheung, DI Jodrell, JT Mettetal, TA ...
Research group: Jodrell Group
E-pub date: 31 Mar 2018
Journal name: Clin Pharmacol Ther

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma.

Authors: N Cook, B Basu, D-M Smith, A Gopinathan, J Evans, WP Steward, D Palmer, D P...
Research group: Jodrell Group
E-pub date: 20 Mar 2018
Journal name: Br J Cancer

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