IL-7-dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response.

Authors: H-C Chen, N Eling, CP Martinez-Jimenez, LM O'Brien, V Carbonaro, JC Marioni...
Research group: Odom Group, Marioni Group, de la Roche Group
E-pub date: 30 Jun 2019
Journal name: EMBO Rep

A cell-engineered system to assess tumor cell sensitivity to CD8+ T cell-mediated cytotoxicity.

Authors: N Nelson, M Lopez-Pelaez, A Palazon, E Poon, M De La Roche, S Barry, V Valg...
Research group: de la Roche Group
E-pub date: 1 Jan 2019
Journal name: Oncoimmunology

Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules.

Authors: FT Ilca, A Neerincx, MR Wills, M de la Roche, LH Boyle
Research group: de la Roche Group
E-pub date: 30 Sep 2018
Journal name: Proc Natl Acad Sci U S A

Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.

Authors: AD Jenks, S Vyse, JP Wong, E Kostaras, D Keller, T Burgoyne, A Shoemark, A ...
Research group: de la Roche Group
E-pub date: 31 May 2018
Journal name: Cell Rep

A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo.

Authors: LD Cassidy, AR Young, PA Pérez-Mancera, B Nimmervoll, A Jaulim, H-C Chen, ...
Research group: de la Roche Group, Narita Group, Gilbertson Group
E-pub date: 1 Jan 2018
Journal name: Autophagy

Aging increases cell-to-cell transcriptional variability upon immune stimulation.

Authors: CP Martinez-Jimenez, N Eling, H-C Chen, CA Vallejos, AA Kolodziejczyk, F Co...
Research group: Odom Group, Marioni Group, de la Roche Group
E-pub date: 31 Mar 2017
Journal name: Science

Origins of the cytolytic synapse.

Authors: M de la Roche, Y Asano, GM Griffiths
Research group: de la Roche Group
E-pub date: 31 Jul 2016
Journal name: Nat Rev Immunol

Hedgehog signaling controls T cell killing at the immunological synapse.

Authors: M de la Roche, AT Ritter, KL Angus, C Dinsmore, CH Earnshaw, JF Reiter, GM ...
Research group: de la Roche Group
E-pub date: 6 Dec 2013
Journal name: Science

Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.

Authors: JED Thaventhiran, A Hoffmann, L Magiera, M de la Roche, H Lingel, M Brunner...
Research group: de la Roche Group
E-pub date: 14 Aug 2012
Journal name: Proc Natl Acad Sci U S A

Centrosome docking at the immunological synapse is controlled by Lck signaling.

Authors: A Tsun, I Qureshi, JC Stinchcombe, MR Jenkins, M de la Roche, J Kleczkowska...
Research group: de la Roche Group
E-pub date: 21 Feb 2011
Journal name: J Cell Biol

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