As a multidisciplinary institute, we have projects suitable for a range of studies from biology to engineering and computer science.

For the 2020 Undergraduate Summer Research Programme, the following Research Group’s are offering summer projects. Please indicate which projects you would be interested in on your application form.

Richard Gilbertson – Cellular and molecular origins of cancer

The principal aim of the Gilbertson Group’s research is to reduce the morbidity and mortality of patients with cancer through improved understanding of tumour biology. With a particular focus on children’s brain tumours, they are working to understand the cellular and molecular origins of cancers and the pathways that drive them.

Maike de la Roche – Cancer Immunology: Hedgehog signalling in T cells

The de la Roche Group are interested in the differentiation, migration and function of CD8 T cells during the adaptive anti-tumour response.

Greg Hannon – Small RNAs and mammalian genomics

The Hannon laboratory has a long-standing interest in small RNA biology. In recent years, the lab has focused on the study of the PIWI-interacting RNAs (piRNAs) in Drosophila melanogaster.

Florian Markowetz – Computational biology

The Markowetz Group develop computational methods to link genomic profiles with quantitative measures of phenotypes, leading towards a comprehensive systems genetics understanding of cancer.

Sarah Bohndiek – Imaging oxygen and oxidative stress

The Bohndiek Group work on devising new imaging approaches to address unanswered questions about the role of oxygen in cancer. Their new imaging approaches predominantly use visible and near-infrared light, to avoid ionising radiation and access relatively low-cost devices.

They achieve developments in this area through a combination of modelling, to understand the interactions between light and tissue; and innovative instrument design, integrating new technologies to enable spectral imaging.

Dario Bressan – Creating virtual reality maps of tumours

In this Cancer Research UK Grand Challenge project, the team aim to build a 3D tumour that can be studied using virtual reality, gathering thousands of bits of information about every single cell in a tumour.

Shankar Balasubramanian – Chemical biology of nucleic acids

The Balasubramanian Group are identifying where base modifications and G4 structures are located in the cancer cell genome, and through the application of synthetic small molecules that selectively target G4 structures, they aim to understand the oncogenic process and develop novel approaches for potential use in treatment and diagnosis of cancer.

James Brenton – Functional genomics of ovarian cancer

The Brenton Group focuses on discovering improved treatments for epithelial ovarian cancer using laboratory and clinical studies.

Masashi Narita – Cellular senescence in cancer and ageing

The Narita Group researches cellular senescence, investigating how gene expression is regulated during senescence and how cell communication modulates senescence-associated phenotypes.

Martin Miller – Cancer systems biology

The Miller Group uses experimental and computational approaches to investigate the tumour microenvironment. To decipher intercellular communication in cancer, they develop and apply technologies that can decompose the transcriptome or label the proteome of specific cell populations in multicellular settings. Their long-term research goal is to better understand how immune cells and stromal cells are involved in oncogenesis and how this can be exploited in cancer therapy.
Computational students only.

Kevin Brindle – Molecular imaging (MRI and MRS)

The primary focus of the Brindle Group is early detection of treatment response with the aim of developing imaging methods that could be used in early phase clinical trials to get an indication of drug efficacy, and subsequently in the clinic to guide treatment in individual patients.

Carlos Caldas – Functional genomics of breast cancer

The Caldas Group has redefined breast cancer as a constellation of 10 genomic driver-based subtypes. They now aim to translate this new molecular taxonomy of breast cancer into the clinic in stratification, tumour monitoring and therapy studies. In parallel, they will continue to develop models to characterize the biology of these subtypes.

Tim Halim – Cancer and the immune system

The Halim Group is interested in understanding the basic immune-regulatory mechanisms in cancer, focusing on a new type of immune-regulatory cell, called the group 2 innate lymphoid cell (ILC2). They are using and developing cutting-edge reagents to study how ILC2-driven inflammation is involved in cancer.

Nitzan Rosenfeld – Molecular and computational diagnostics

The Rosenfeld Group employ emerging molecular technologies to develop new diagnostic approaches. Their focus is on circulating tumour DNA (ctDNA) as a noninvasive modality to assess the evolution of solid malignancies.

John Marioni – Single-cell and computational biology

The Marioni group develops and applies statistical tools to analyse complex, large-scale datasets in order to understand cell fate decisions in the context of development, the immune system and in cancer.

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