At CRUK Cambridge Institute, we perform world leading science which focuses on positively impacting cancer patients’ lives. In the Pre-Clinical Genome Editing team, our mission is to make meaningful advances to understand and treat cancer. We use cutting edge technologies to create authentic models of disease for study, and to gain novel biological insight.

As a Transgenics Specialist, you will join the highly specialised Pre-Clinical Genome Editing team, and apply your expertise to generate of novel murine models. Our team has a wealth of expertise in Transgenics and CRISPR technology, its innovation and its application both in vitro and in vivo. You will drive our capability to edit complex cellular systems (eg mouse Embryonic Stem cells and mouse embryos of varying stages) and deliver key Transgenics services to the CRUK CI. You will have a passion for advancing Transgenic technology, and will have a track record in working collaboratively with researchers to bring technological solutions to important biological questions.

Key Responsibilities:

You will drive our Transgenics capability by:

  • Drawing upon your extensive expertise in Transgenics technologies, including: Embryonic Stem Cell transgenesis, Embryo transgenesis, IVF, rederivation and gamete cryopreservation
  • Play a leading role in our ES pipeline (derivation, manipulation, culturing and injection)
  • Applying your knowledge in the design, execution and interpretation of new murine model generation using CRISPR-Cas9 ¿ via both the ES and Embryo route
  • Aid the Transgenics Manager in project and budget management
  • Support the early adoption and development of new Transgenic technologies

Minimum Requirements:

  • A relevant higher education degree or other relevant qualification
  • Demonstrable evidence of delivering on transgenics projects
  • Expertise in ES cell derivation, manipulation, culturing and implantation
  • Expertise in advanced molecular techniques (eg cloning, Gibson assembly, PCR design, etc)
  • Practical and theoretical mastery of key transgenic techniques
  • Ability to work independently and as part of a hard-working, motivated and enthusiastic team.
  • Proactive and flexible, with a proven ability to perform under pressure.
  • Excellent and effective communication skills are essential to this role.

Candidates will be required to work outside of normal working hours.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.

Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.


The closing date for applications is 7 August 2020, with the interview date TBC.

Please quote reference SW23443 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

10 Jul 2020
7 Aug 2020