At CRUK Cambridge Institute, we perform world leading science which focuses on positively impacting cancer patients’ lives. In the Pre-Clinical Genome Editing team, our mission is to make meaningful advances to understand and treat cancer. We use cutting edge technologies to create authentic models of disease for study, and to gain novel biological insight.

As a Senior Scientific Associate, you will join the highly specialised Pre-Clinical Genome Editing team, and apply your expertise in CRISPR gene editing to challenging, patient-relevant model systems. Our team has a wealth of expertise in CRISPR technology, its innovation and its application both in vitro and in vivo. You will complement our capability to edit complex cellular systems (eg patient derived PBMCs, mouse Embryonic Stem cells) while working collaboratively with researchers to bring technological solutions to important biological questions.

Key Responsibilities:

You will complement our Genome Editing capability by:

  • Drawing upon your substantive expertise in the growth and manipulation of primary human PBMCs and mouse Embryonic Stem cells
  • Applying your expertise in the design, execution and interpretation of CRISPR-Cas9 projects
  • Utilising your expertise in the design, preparation and transduction of viral vectors (eg AAV, Lenti)
  • Working collaboratively with research groups and other core facilities to deliver high impact CRISPR-based projects (in vitro and in vivo)

Minimum Requirements:

  • A PhD or other relevant qualification
  • Demonstrable evidence of driving a research project in an autonomous fashion
  • Expertise in advanced molecular techniques (eg Cell Culture, Viral Vectors, Gibson assembly, recombineering)
  • Expertise in genome editing technologies is essential
  • Statistical computation (eg R) fluency desirable
  • Ability to work independently and as part of a hard-working, motivated and enthusiastic team.
  • Proactive and flexible, with a proven ability to perform under pressure.
  • Excellent and effective communication skills are essential to this role.

Candidates may will be occasionally required to work outside of normal working hours.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check. As the candidate will be working with primary human tissue, Occupational Health clearance will be mandatory.

Temporary cover: This post is fixed-term for 18 months or 3 months from the return of the post holder, whichever is the earlier.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.

Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online.

The closing date for applications is the 10th August 2020, with the interview date TBC.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SW23449 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

13 Jul 2020
10 Aug 2020