In vivo Specialist (Senior Scientific Associate) (Fixed Term)
Cancer Research UK Cambridge Institute, University of Cambridge School of Clinical Medicine.

At the CRUK Cambridge Institute, we perform world-leading science that focuses on positively impacting cancer patients’ lives. In the Pre-Clinical Genome Editing team, our mission is to make meaningful advances to understand and treat cancer. We use cutting edge technologies to create authentic models of disease for study, and to gain novel biological insight.

The Pre-Clinical Genome Editing facility specialises in bringing the precise manipulation of genomes to a diverse range of research and clinical based projects. The Core spans a wide spectrum of bench-to-bedside translational research, focusing on the design and implementation of experiments involving:

1) Creation of novel models of disease both in vitro and in vivo

2) Utilisation of novel models in pre-clinical therapeutic studies

As an In vivo Specialist, you will join a specialised ‘Small Animal Hospital’ team within the Pre-Clinical Genome Editing facility. The purpose of this role will be to support development and interrogation of clinically relevant small animal tumour models in order to identify and robustly test novel radiotherapy strategies. These models will be designed to recapitulate clinical radiotherapy allowing seamless progression to clinical trials in patients.
Studies will utilise either transplantable models (patient-derived xenografts, orthotopics) or genetically engineered mouse models (GEMM) and will span a variety of cancer types (typically brain and breast). You will enhance our capability in this area by working with a team of cross-functional scientists to deliver this key pre-clinical platform, supporting CRUK CI’s mission.

Purpose of the role

-To work as an experienced in vivo specialist as part of the Small Animal Hospital (SAH) team within the Pre-Clinical Genome Editing Core facility

-To support development of clinically relevant small animal models of cancer, recapitulating clinical radiotherapy with or without drug therapies

-To drive in vivo capabilities of the SAH in models of brain and breast cancer by delivering targeted radiotherapy (using the Small Animal Radiation Research Platform (SARRP)) typically combined with drug therapies, followed by assessment of treatment responses using non-invasive imaging techniques

-To support the SAH manager to advance and develop novel models/methods to sustain a platform for radiotherapy-driven pre-clinical therapeutic trials

Candidates will be required to work outside of normal working hours (e.g. weekends or occasional Bank Holidays).

Once an offer of employment is accepted, the successful candidate will be required to undergo a health assessment and a security check. As the candidate will be working with primary human tissue, Occupational Health clearance will be mandatory.

Closing date: 11th October 2021

Interviews: TBC

Fixed-term: The funds for this post are available until 30 October 2024 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.

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