The Carroll laboratory is focused on understanding mechanisms of steroid receptor (SR) transcriptional activity in cancer, in particular estrogen receptor (ER) in breast cancer (http://www.carroll-lab.org.uk/). We take a genomic, proteomic and molecular approach to delineate mechanisms underlying SR activity, with particular emphasis on defining mechanisms that contribute to tumorigenesis and drug resistance.
Applications are invited for a Scientific Associate (Lab technician) or Senior Scientific Associate (Lab manager) to join our team to progress projects within the laboratory. Specifically, our lab is interested in using our tools, in conjunction with the recent advances in breast cancer models to explore the changes in ER function in breast cancer metastasis. In addition, recent similarities in molecular processes have been observed between breast and prostate/pancreatic cancer and we are interested in pursuing these questions. This will involve detailed pathway biology and will revolve around our interest in characterising transcription factors in cancer.
You will have the opportunity to work under your own initiative and apply your problem-solving skills to troubleshoot challenging technical issues. You will provide project management, scientific support and training to other team members, including Research Associates, Academic Clinical Fellows, PhD student and Senior/Bioinformatic Analysts. For the grade 7 role, you will have prior experience of lab management responsibilities and for both the grade 6 and 7 roles, you will assist in administration and management of lab finances and operations. You will be the representative for the lab, with core facilities and wider collaborations. You will be responsible for health and safety aspects of the lab.
This is a position that requires a large amount of initiative, attention to detail and a mature approach to dealing with colleagues. The selected candidate is expected to have a BSc and ideally a MSc in a relevant subject (or the equivalent level of skill and knowledge) for the grade 6 role or a PhD in a relevant subject for the grade 7 role. They must have hands on experience of cancer cell models and be willing to learn about genomics and in vivo modelling of cancer.
The role holder will possess some research experience with molecular biology and biochemical expertise. Experience in cancer biology is desirable and ideally, previous experience in a cancer research lab would be a benefit. Previous genomic experience would be an advantage but is not essential.
Potential candidates must display an ability to undertake project management, work within a multi-disciplinary team environment, demonstrate excellent presentation and communication skills and be able to train other team members. They will work closely with Prof. Carroll to facilitate the research.
Fixed-term: The funds for this post are available for 3 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.
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Closing Date: 11th December 2022
Interview Date: TBC
Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference SW34265 on your application and in any correspondence about this vacancy.
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