The Liquid Biopsies and Cancer Diagnostics lab at the Cancer Research UK Cambridge Institute, University of Cambridge, develops and pioneers new approaches for non-invasive molecular diagnostics for cancer, primarily based on next-generation sequencing (NGS) of circulating cell-free tumour DNA (ctDNA). Led by Dr Rosenfeld and a team of experienced translational genomics scientists, the lab studies large collections of plasma and other samples from cancer patients through an extensive portfolio of clinical studies and collaborations. We develop NGS analysis tools spanning genome-wide and targeted methods for sensitive detection of tumour-derived nucleic acids and aim to progress these into clinical use by proof-of-concept translational studies to demonstrate their utility. We further explore the biophysical properties of ctDNA to study its origins and interactions and to inform the development of increasingly sensitive methods.

The lab and its collaborators have produced some of the key milestones in the liquid biopsy field using gene panels, exome sequencing, and shallow whole genome sequencing to detect, analyse and monitor ctDNA in plasma samples from hundreds of patients with different cancer types. The group is a dynamic mix of molecular biologists, bioinformaticians and clinical fellows providing a unique environment for development and learning in cancer genomics and translational research, with a strong focus on clinical application.

We are seeking to recruit an outstanding lab-based molecular biologist with a PhD, who has extensive experience in the development of next generation sequencing assays, particularly TCR/BCR-sequencing assays and/or circulating tumour DNA diagnostic assays in the field of cancer genomics. The successful candidate will play a key role in a large-scale project for earlier diagnosis of cancer, funded by generous grants from Cancer Research UK. The ideal candidate will have considerable experience in lab-based genomic research, with experience of developing genomic assays for immunology (essential), preferably TCR/BCR sequencing assays, and bioinformatics skills in the analysis of immune repertoires and NGS data. Experience of research using human samples and in the development of clinical diagnostic assays and integrating genomic data from multiple sources would be a distinct advantage. You will be a highly motivated, detail-oriented individual with excellent communication skills and who is well organised. You will be able to work independently and interact effectively in a multi-disciplinary team environment.

Informal enquiries may be made to the Rosenfeld lab management team by emailing

Fixed-term: The funds for this post are available until 29 February 2024 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

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Closing date: 19 May 2021. The interview date is TBC.

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