At CRUK Cambridge Institute, we perform world leading science which focuses on positively impacting cancer patients’ lives. Our mission is to exploit cutting edge technologies to make meaningful advances in the understanding and treatment of cancer.

As a Research Associate, you will have the unique opportunity to lead a project that bridges the Narita lab (Ageing, Senescence) and our specialised Genome Editing facility (CRISPR, animal models). This project is funded by the CRUK Pioneer Award, which funds revolutionary, game changing ideas. You will design a CRISPR-based barcoding strategy and apply this to mouse Embryonic Stem cells (mESCs), with the ultimate goal of uncovering key attributes that allow a stem cell to become a model organism.

Key areas of the project:

  • Molecular barcoding (CASpicr): developing a next-generation CRISPR-based barcoding strategy and applying this to mESCs
  • Feature recognition: use cutting edge single cell and computational approaches (transcriptome, epigenome and genome) to define features that report a cell’s ability to form an organism
  • Biomarker development: develop a non-invasive biomarker to detect these epigenotypes in naïve populations of stem cells

You will work in an interdisciplinary, collaborative and innovative environment. Collaborating with world leaders in single cell sequencing (Dr Wolf Reik, Babraham Institute) and in single cell analysis (Dr John Marioni, CRUK Cambridge Institute).

This position will suit a scientist with strong molecular and computational biology expertise, who desires to apply their skills to a paradigm-shifting, translational project.

Key Requirements:
Computational approaches:

  • Experience of the manipulation and analysis of NGS datasets (eg R/Python)
  • Fluency in computation and statistical theory

Molecular expertise:

  • Strong cloning background (eg Gibson Assembly)
  • Lentiviral experience

Cell culture:

  • Expertise in cell culture (mouse ES cell culture an advantage)

A PhD or relevant qualification; Excellent and effective communication skills.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check. As the candidate will be working with primary human tissue, Occupational Health clearance will be mandatory.

To apply online for this vacancy, please click on the ‘Apply’ button below. This will route you to the University’s Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

The closing date is 27 January 2019, with the interview due to be held on week commencing 4th February 2019.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference SW17773 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

SALARY
£32,236-£39,609
REFERENCE
SW17773
CATEGORY
Research
PUBLISHED
21 Dec 2018
CLOSING DATE
27 Jan 2019
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