The Cancer Research UK Cambridge Institute (CRUK CI) is a joint venture between the Charity, Cancer Research UK, and the University of Cambridge. The Institute has excellent state-of-the-art facilities and research ranges from basic cancer biology and computational biology through to translational research and clinical application. Graduate students play a pivotal role in the continuing success of our research programmes and gaining a studentship in the Institute is an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future. For further information, go to: https://www.cruk.cam.ac.uk/jobs-and-studentships/postgraduate-study
Professor Jason Carroll, Head of the research group studying Nuclear Receptor Transcription, wishes to appoint a student to work on the project entitled: Characterising estrogen receptor associated factors in breast cancer. For further information about Professor Carroll’s group, go to http://www.carroll-lab.org.uk/
Estrogen Receptor (ER) is the defining feature of luminal breast cancers, where it functions as a transcription factor. ER utilises a number of associated proteins to effectively maintain DNA interactions and regulate the target genes that culminate in cell division. We have recently developed a quantitative proteomic method called qPLEX-RIME that permits unbiased discovery of protein-protein interactions from clinical tissue. This has revealed many hundreds of putative novel ER-regulatory proteins. When coupled with CRISPR screening data, there are more than 100 ER-associated proteins that are also required for ER transcriptional activity. This project will focus on defining key candidates within these datasets that are differentially associated with ER in different stages of disease progression, with a focus on the proteins that contribute to drug resistance. Specifically, the project will involve characterisation of key candidate proteins that modulate ER activity. In addition, the project will involve detailed identification of the changes in protein interactions that occur during disease progression from primary tumours to metastases. Detailed functional assessment of candidate factors will be conducted and the potential role in mediating ER function will be defined.
The student will have either a Masters research degree or an excellent undergraduate degree plus additional wet lab experience. Previous experience in cell culture, molecular biology and biochemistry assays is required. Any previous experience in cancer research is also expected and genomic/proteomic experience would be a benefit, but is not essential.
This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of £19,000 per annum.
No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.
How to apply
All applications need to be made using the University Applicant Portal. Please visit: https://www.graduate.study.cam.ac.uk/courses/directory/cvcrpdmsc for further information about the course and to access the applicant portal.
To complete your on-line application, you need to provide the following:
Reference Request: The names and contact details of two academic referees who have agreed to act on your behalf.
Research: If you wish to be considered for more than one studentship, please enter the names of all of the supervisors you wish to consider your application in the ‘Research summary’ text box. If you only wish your application to be considered by a single supervisor, then please enter their name in the ‘Research Supervisor’ text box. Please describe your past ‘Research experience’ in the appropriate text box.
Course Specific Questions: Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.
Supporting Documents: Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results
The closing date for applications is 15 November 2019, with interviews expected to take place in December/January.
Please quote reference SW20739 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.