Applications are invited for a position in the Caldas Laboratory at the CRUK Cambridge Institute (CRUK-CI) as a Bioinformatician. Led by Prof. Carlos Caldas, the group is involved in world leading clinical and laboratory research into breast cancer, and is staffed by a multi-disciplinary team, including oncologists, pathologists, biologists, computational scientists, statisticians and laboratory staff.

During the last years, the lab has redefined this disease as a constellation of at least 11 genomic driver-based subtypes, with different molecular profiles and patient prognosis. This new molecular taxonomy of breast cancer is being translated into the clinic in stratification, tumour monitoring and therapy studies. In parallel we are developing pre clinical models to characterize the biology of these subtypes.
We are studying now the effect of intratumoral heterogeneity in each of these subtypes. In particular, we aim to quantify copy number-based and single nucleotide variation-based heterogeneity using a combination of bulk sequencing and single-cell sequencing, both at the genomic and transcriptomic level. We will use clinical samples and patient derived-xenogratfs (PDTX).

We are looking for a candidate with a PhD or Ms in Bioinformatics, Statistics or Computational Biology with experience in Next Generation Sequencing data analysis.

The successful candidate will work on refining pipelines for analysis of high- throughput data, applying existing algorithms for estimation of intratumoral heterogeneity as well as developing new approaches and models. R/Bioconductor proficiency is required.

The post-holder will work as part of a multi-disciplinary team with colleagues at all levels.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment and a security check.

To apply online for this vacancy, please click on the ‘Apply’ button below. This will route you to the University’s Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Any queries regarding this post should be directed to Oscar Rueda by e-mail at

The closing date for applications is 10 January 2019.

Please quote reference SW17547 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Caldas Laboratory
29 Nov 2018
10 Jan 2019