Associate Scientist

Research Group Home Page: 

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Characterisation of PALB2 tumours through whole-exome and whole-transcriptomic analyses.

E-pub date: 31 Mar 2021


Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response.

E-pub date: 28 Feb 2021


NRG1 fusions in breast cancer.

E-pub date: 31 Dec 2020


Germline APOBEC3B deletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype, PIK3CA mutations, and immune activation.

E-pub date: 31 Dec 2020


The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences.

E-pub date: 30 Nov 2020


Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.

E-pub date: 31 Oct 2020


Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.

E-pub date: 31 Aug 2020


Sex differences in oncogenic mutational processes.

E-pub date: 31 Jul 2020


Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated features.

E-pub date: 31 May 2020


The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver.

E-pub date: 31 May 2020


A reference map of the human binary protein interactome.

E-pub date: 01 Apr 2020


Pan-cancer analysis of whole genomes.

E-pub date: 01 Feb 2020


Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer

E-pub date: 01 Feb 2020


Combination of BET and FGFR inhibition as a rational therapeutic strategy for invasive lobular breast cancer

E-pub date: 01 Feb 2020


Imaging breast cancer using hyperpolarized carbon-13 MRI.

E-pub date: 31 Dec 2019


A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.

E-pub date: 31 Dec 2019


Genomic analysis of malaysian breast cancers unravel molecular differences from Caucasian breast cancers

E-pub date: 01 Nov 2019


Personalized circulating tumor DNA analysis to detect residual disease after neoadjuvant therapy in breast cancer.

E-pub date: 31 Jul 2019


BET inhibition as a rational therapeutic strategy for invasive lobular breast cancer.

E-pub date: 31 Jul 2019


The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer.

E-pub date: 30 Apr 2019


Publisher Correction: Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy.

E-pub date: 30 Apr 2019


Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups.

E-pub date: 28 Feb 2019


PDLIM2 is a marker of adhesion and β-catenin activity in triple-negative breast cancer.

E-pub date: 28 Feb 2019


Dynamics of breast cancer relapse reveal molecularly defined late recurring ER-positive subgroups: Results from the METABRIC study

E-pub date: 01 Feb 2019


Multiplexed targeted digital sequencing of circulating tumor DNA to detect minimal residual disease in early and locally advanced breast cancer

E-pub date: 01 Feb 2019


Genome copy number entropy as predictor of response for neoadjuvant therapy in early breast cancer

E-pub date: 01 Feb 2019


Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy.

E-pub date: 31 Jan 2019


Genome-wide association study of germline variants and breast cancer-specific mortality.

E-pub date: 31 Jan 2019


Next Generation-Targeted Amplicon Sequencing (NG-TAS): an optimised protocol and computational pipeline for cost-effective profiling of circulating tumour DNA.

E-pub date: 31 Dec 2018


Shallow whole genome sequencing for robust copy number profiling of formalin-fixed paraffin-embedded breast cancers

E-pub date: 30 Nov 2018


Germline pathogenic variants in PALB2 and other cancer-predisposing genes in families with hereditary diffuse gastric cancer without CDH1 mutation: a whole-exome sequencing study.

E-pub date: 31 Jul 2018


Molecular Classification of Breast Cancer.

E-pub date: 01 Jul 2018


PO-387 Differential gene methylation in triple negative breast cancer and non-tumoral mammary tissue

E-pub date: 01 Jul 2018


PO-386 Decoding the regulatory role and epiclonal dynamics of DNA methylation in 1482 breast tumours

E-pub date: 01 Jul 2018


Bromodomain inhibitors for the treatment of invasive lobular carcinoma

E-pub date: 01 Jul 2018


Next Generation-Targeted Amplicon Sequencing (NG-TAS): An optimised protocol and computational pipeline for cost-effective profiling of circulating tumour DNA

E-pub date: 30 Jun 2018


Shallow whole genome sequencing for robust copy number profiling of formalin-fixed paraffin-embedded breast cancers.

E-pub date: 01 Jun 2018


Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.

E-pub date: 31 May 2018


αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer.

E-pub date: 17 May 2018


Integrative cluster classification to predict pathological complete response to neoadjuvant chemotherapy in early breast cancer

E-pub date: 30 Apr 2018


Dynamic genomic instability modulation by neoadjuvant therapy in early breast cancer (GEICAM/2006-03_2006-14)

E-pub date: 30 Apr 2018


Associations between genomic stratification of breast cancer and centrally reviewed tumour pathology in the METABRIC cohort.

E-pub date: 07 Mar 2018


Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts.

E-pub date: 05 Jan 2018


Body mass index and breast cancer survival: a Mendelian randomization analysis.

E-pub date: 01 Dec 2017


The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting.

E-pub date: 25 Aug 2017


Big data in cancer genomics

E-pub date: 31 Jul 2017


Therapeutic Rationale to Target Highly Expressed CDK7 Conferring Poor Outcomes in Triple-Negative Breast Cancer.

E-pub date: 15 Jul 2017


Intersect-then-combine approach: improving the performance of somatic variant calling in whole exome sequencing data using multiple aligners and callers.

E-pub date: 18 Apr 2017


Subtype-specific micro-RNA expression signatures in breast cancer progression.

E-pub date: 01 Sep 2016


Prognostic Value of MammaPrint® in Invasive Lobular Breast Cancer.

E-pub date: 31 Aug 2016


A computational approach to discriminate between human and mouse reads in sequencing data from Patient Derived Tumour Xenografts

E-pub date: 01 Jul 2016


Identifying changes in mutational dynamics in patients with early breast cancer undergoing neoadjuvant chemotherapy

E-pub date: 01 Jul 2016


Dynamics of relapse in breast cancer

E-pub date: 01 Jul 2016


The somatic mutation profiles of 173 genes in over 2400 primary breast cancers

E-pub date: 01 Jul 2016


RATHER: High resolution molecular profiling of invasive lobular breast cancers

E-pub date: 01 Jul 2016


Erratum: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes.

E-pub date: 06 Jun 2016


The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.

E-pub date: 10 May 2016


CDK7: A marker of poor prognosis and tractable therapeutic target in triple-negative breast cancer

E-pub date: 31 Jan 2016


Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.

E-pub date: 05 Jan 2016


Molecular classification and testing of breast carcinoma

E-pub date: 31 Dec 2015


Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.

E-pub date: 04 Nov 2015


BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential.

E-pub date: 31 Oct 2015


Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.

E-pub date: 31 Aug 2015


Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

E-pub date: 01 Jun 2015


Identification of novel genetic markers of breast cancer survival.

E-pub date: 31 May 2015


Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.

E-pub date: 23 Apr 2015


Common germline polymorphisms associated with breast cancer-specific survival.

E-pub date: 22 Apr 2015


Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53.

E-pub date: 31 Mar 2015


A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

E-pub date: 31 Jan 2015


BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells.

E-pub date: 09 Jan 2015


Lymphocyte invasion of basal breast tumors is associated with wild-type p53

E-pub date: 31 Dec 2014


Identification of fusion genes through kinome-centered RNA sequencing in different types of solid tumors

E-pub date: 01 Nov 2014


Genome-driven integrated classification of breast cancer validated in over 7,500 samples.

E-pub date: 28 Aug 2014


Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

E-pub date: 01 Aug 2014


TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.

E-pub date: 01 Jul 2014


22p * development of a brca1-like signature in triple negative breast cancers within the rather (rational therapy for breast cancer) consortium.

E-pub date: 31 May 2014


Processed pseudogenes acquired somatically during cancer development.

E-pub date: 09 Apr 2014


Defining clinically relevant molecular subtypes in lobular breast cancer within the RATHER consortium

E-pub date: 30 Nov 2013


A copy number and expression based classifier for breast cancer tumors

E-pub date: 01 Oct 2013


A targeted sequencing approach to characterize the mutational profiles of 178 genes in 2600 primary breast tumors

E-pub date: 01 Oct 2013


TOX3 mutations in breast cancer.

E-pub date: 31 Aug 2013


Master regulators of FGFR2 signalling and breast cancer risk.

E-pub date: 31 Aug 2013


A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.

E-pub date: 31 Aug 2013


The shaping and functional consequences of the microRNA landscape in breast cancer.

E-pub date: 16 May 2013


Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA.

E-pub date: 02 May 2013


BRCA1-like signature in triple negative breast cancers within the RATHER (Rational Therapy for Breast Cancer) Consortium

E-pub date: 31 Mar 2013


Development of comprehensive molecular portraits of lobular breast cancer within the RATHER (Rational Therapy for Breast Cancer) Consortium.

E-pub date: 31 Mar 2013


Analysis of circulating tumor DNA to monitor metastatic breast cancer.

E-pub date: 28 Mar 2013


Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.

E-pub date: 21 Feb 2013


Ab-initio calculation of C and CO adsorption on the Co (110) surface

E-pub date: 31 Jan 2013


Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes.

E-pub date: 22 Dec 2012


Copy number variation and risk of chemotherapy-related infection

E-pub date: 30 Nov 2012


Copynumber: Efficient algorithms for single- and multi-track copy number segmentation.

E-pub date: 04 Nov 2012


Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling (Science Translational Medicine (2012) 4, (161er6))

E-pub date: 31 Oct 2012


Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer.

E-pub date: 31 Oct 2012


Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling.

E-pub date: 24 Oct 2012


Calling sample mix-ups in cancer population studies.

E-pub date: 31 Aug 2012


Non-invasive Monitoring of Metastatic Breast Cancer by Circulating Tumour DNA – a Comparison With Circulating Tumour Cells

E-pub date: 01 Jul 2012


Experimental and theoretical study of electron-beam-induced spin-reorientation transition reversal in the CO/Co(110) system

E-pub date: 30 Jun 2012


The landscape of cancer genes and mutational processes in breast cancer.

E-pub date: 16 May 2012


The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.

E-pub date: 18 Apr 2012


Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers.

E-pub date: 18 Apr 2012


The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

E-pub date: 04 Apr 2012


MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle.

E-pub date: 14 Feb 2012


Differential oestrogen receptor binding is associated with clinical outcome in breast cancer.

E-pub date: 04 Jan 2012


Modification of the secondary-electron spin polarization in Co/Cu(110) films via gaseous adsorbates

E-pub date: 31 Oct 2011


Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinoma.

E-pub date: 31 Oct 2011


Electron Beam Tuning of the Magnetic Anisotropy in Co/Cu(110) Films

E-pub date: 01 Jun 2011


NOVEL PROGNOSTIC TARGETS IDENTIFIED USING INTEGRATED ANALYSIS OF COPY NUMBER AND EXPRESSION DATA IN OESOPHAGEAL ADENOCARCINOMA

E-pub date: 01 Apr 2011


Novel prognostic targets identified using integrated analysis of copy number and expression data in esophageal adenocarcinoma

E-pub date: 31 Mar 2011


ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.

E-pub date: 31 Mar 2011


Genomic architecture characterizes tumor progression paths and fate in breast cancer patients.

E-pub date: 30 Jun 2010


Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas.

E-pub date: 31 May 2010


Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.

E-pub date: 01 Mar 2010


The pitfalls of platform comparison: DNA copy number array technologies assessed.

E-pub date: 08 Dec 2009


A metadata approach for clinical data management in translational genomics studies in breast cancer.

E-pub date: 30 Nov 2009


The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.

E-pub date: 19 Nov 2009


Germline CDH1 deletions in hereditary diffuse gastric cancer families.

E-pub date: 01 May 2009


Chromosome translocations and fusion genes in breast cancer.

E-pub date: 31 Dec 2008


High-resolution array CGH clarifies events occurring on 8p in carcinogenesis.

E-pub date: 07 Oct 2008


PMC42, a breast progenitor cancer cell line, has normal-like mRNA and microRNA transcriptomes.

E-pub date: 31 Aug 2008


Chromosome translocations in breast cancer

E-pub date: 01 Aug 2008


NRG1 is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene

E-pub date: 01 Aug 2008


ESR1 gene amplification in breast cancer: a common phenomenon?

E-pub date: 31 Jul 2008


Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer.

E-pub date: 06 May 2008


High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53.

E-pub date: 01 May 2008


Regulation of p53 tetramerization and nuclear export by ARC.

E-pub date: 26 Dec 2007


MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype.

E-pub date: 31 Aug 2007


High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer.

E-pub date: 31 Aug 2007


Co-amplification of 8p12 and 11q13 in breast cancers is not the result of a single genomic event.

E-pub date: 31 May 2007


Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers.

E-pub date: 22 Mar 2007


Cross-platform array comparative genomic hybridization meta-analysis separates hematopoietic and mesenchymal from epithelial tumors.

E-pub date: 01 Mar 2007


p300 is required for orderly G1/S transition in human cancer cells.

E-pub date: 31 Dec 2006


ZNF198, a zinc finger protein rearranged in myeloproliferative disease, localizes to the PML nuclear bodies and interacts with SUMO-1 and PML.

E-pub date: 31 Oct 2006


Spatial associations of humus, nutrients and soils in mixed dipterocarp forest at Lambir, Sarawak, Malaysian Borneo

E-pub date: 01 Sep 2006


Comparative genomic hybridization of esophageal adenocarcinoma and squamous cell carcinoma cell lines.

E-pub date: 01 Aug 2006


Impaired transforming growth factor beta signalling in Barrett’s carcinogenesis due to frequent SMAD4 inactivation.

E-pub date: 01 Jun 2006


Erratum: Comparative genomic hybridization of esophageal adenocarinoma and squamous cell carcinoma cell lines (Diseases of the Esophagus (2006) vol. 19 (10-34))

E-pub date: 31 Mar 2006


Telomerase- and alternative telomere lengthening-independent telomere stabilization in a metastasis-derived human non-small cell lung cancer cell line: effect of ectopic hTERT.

E-pub date: 31 Mar 2006


Human and mouse oligonucleotide-based array CGH.

E-pub date: 30 Nov 2005


A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes.

E-pub date: 31 Jul 2005


Shadow-evaporated nanometre-sized gaps and their use in electrical studies of nanocrystals

E-pub date: 01 Jun 2005


Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.

E-pub date: 01 May 2005


Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays.

E-pub date: 01 Feb 2005


Geminin predicts adverse clinical outcome in breast cancer by reflecting cell-cycle progression.

E-pub date: 01 Oct 2004


A recurrent chromosome breakpoint in breast cancer at the NRG1/neuregulin 1/heregulin gene.

E-pub date: 30 Sep 2004


p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels.

E-pub date: 30 Apr 2004


EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.

E-pub date: 31 Oct 2003


A simple and reliable pretreatment protocol facilitates fluorescent in situ hybridisation on tissue microarrays of paraffin wax embedded tumour samples.

E-pub date: 01 Oct 2003


DNA damage-induced [Zn(2+)](i) transients: correlation with cell cycle arrest and apoptosis in lymphoma cells.

E-pub date: 31 Aug 2002


Degenerate oligonucleotide primed-polymerase chain reaction-based array comparative genomic hybridization for extensive amplicon profiling of breast cancers : a new approach for the molecular analysis of paraffin-embedded cancer tissue.

E-pub date: 01 May 2001


Absence of rearrangements in the BRCA2 gene in human cancers.

E-pub date: 01 Jan 2001


Molecular cytogenetic analysis of breast cancer cell lines.

E-pub date: 01 Nov 2000


Mutations truncating the EP300 acetylase in human cancers.

E-pub date: 01 Mar 2000


MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines.

E-pub date: 30 Nov 1999


Cell cycle checkpoint evasion and protracted cell cycle arrest in X-irradiated small-cell lung carcinoma cells.

E-pub date: 01 Sep 1999


On the spheroidal bag

E-pub date: 30 Sep 1983


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