Senior group leader

Research Group Home Page: 
Balasubramanian Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Publisher Correction: DNA sequencing at 40: past, present and future.

E-pub date: 31 Mar 2019


Whole genome experimental maps of DNA G-quadruplexes in multiple species.

E-pub date: 28 Feb 2019


The detection, structure and function of modified DNA bases.

E-pub date: 28 Feb 2019


Correction to: RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs.

E-pub date: 31 Dec 2018


Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.

E-pub date: 30 Nov 2018


RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs.

E-pub date: 30 Nov 2018


DNA G-quadruplex structures mold the DNA methylome.

E-pub date: 30 Sep 2018


5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells.

E-pub date: 30 Sep 2018


Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts.

E-pub date: 31 Aug 2018


Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome.

E-pub date: 02 Jul 2018


Sequencing 5-Hydroxymethyluracil at Single-Base Resolution.

E-pub date: 07 Jun 2018


Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.

E-pub date: 01 Jun 2018


NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence.

E-pub date: 09 May 2018


Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing.

E-pub date: 31 Mar 2018


Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule.

E-pub date: 22 Mar 2018


Synthesis and Multiple Incorporations of 2′-O-Methyl-5-hydroxymethylcytidine, 5-Hydroxymethylcytidine and 5-Formylcytidine Monomers into RNA Oligonucleotides.

E-pub date: 16 Nov 2017


Machine learning model for sequence-driven DNA G-quadruplex formation.

E-pub date: 06 Nov 2017


Local epigenetic reprogramming induced by G-quadruplex ligands.

E-pub date: 01 Nov 2017


DNA sequencing at 40: past, present and future.

E-pub date: 30 Sep 2017


Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma.

E-pub date: 31 Aug 2017


Therapeutics: Click and discover.

E-pub date: 09 Aug 2017


The Profile and Dynamics of RNA Modifications in Animals.

E-pub date: 01 Jun 2017


DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential.

E-pub date: 31 May 2017


Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications.

E-pub date: 04 May 2017


G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition.

E-pub date: 31 Mar 2017


CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

E-pub date: 17 Feb 2017


2′-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA.

E-pub date: 08 Feb 2017


Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming.

E-pub date: 31 Jan 2017


Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite Leishmania.

E-pub date: 30 Jan 2017


Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides.

E-pub date: 24 Jan 2017


Single genome retrieval of context-dependent variability in mutation rates for human germline.

E-pub date: 13 Jan 2017


Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing.

E-pub date: 02 Nov 2016


rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome.

E-pub date: 31 Oct 2016


DSBCapture: in situ capture and sequencing of DNA breaks.

E-pub date: 31 Oct 2016


G-quadruplex structures mark human regulatory chromatin.

E-pub date: 31 Oct 2016


Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.

E-pub date: 25 Oct 2016


An Epigenetics-Inspired DNA-Based Data Storage System.

E-pub date: 05 Sep 2016


Enhanced Methylation Analysis by Recovery of Unsequenceable Fragments.

E-pub date: 31 Aug 2016


Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA.

E-pub date: 25 Jul 2016


In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine.

E-pub date: 29 Jun 2016


Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases.

E-pub date: 12 Mar 2016


Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes.

E-pub date: 27 Jan 2016


Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies.

E-pub date: 10 Nov 2015


High-throughput sequencing of DNA G-quadruplex structures in the human genome.

E-pub date: 31 Aug 2015


Accurate measurement of 5-methylcytosine and 5-hydroxymethylcytosine in human cerebellum DNA by oxidative bisulfite on an array (OxBS-array).

E-pub date: 31 Aug 2015


5-Formylcytosine can be a stable DNA modification in mammals.

E-pub date: 31 Aug 2015


Selective Chemical Labeling of Natural T Modifications in DNA.

E-pub date: 29 Jul 2015


FOXM1 binds directly to non-consensus sequences in the human genome.

E-pub date: 23 Jun 2015


Targeted Detection of G-Quadruplexes in Cellular RNAs.

E-pub date: 01 Jun 2015


G-quadruplex ligands exhibit differential G-tetrad selectivity.

E-pub date: 11 May 2015


Chemical methods for decoding cytosine modifications in DNA.

E-pub date: 25 Mar 2015


Formation and abundance of 5-hydroxymethylcytosine in RNA.

E-pub date: 23 Mar 2015


Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase.

E-pub date: 27 Feb 2015


Decoding genomes.

E-pub date: 01 Feb 2015


5-Formylcytosine alters the structure of the DNA double helix.

E-pub date: 31 Jan 2015


Solexa sequencing: decoding genomes on a population scale.

E-pub date: 31 Jan 2015


oxBS-450K: a method for analysing hydroxymethylation using 450K BeadChips.

E-pub date: 15 Jan 2015


Dual binding of an antibody and a small molecule increases the stability of TERRA G-quadruplex.

E-pub date: 12 Jan 2015


Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex.

E-pub date: 12 Jan 2015


5-Hydroxymethylcytosine is a predominantly stable DNA modification.

E-pub date: 31 Dec 2014


Targeting DNA G-quadruplexes with helical small molecules.

E-pub date: 24 Nov 2014


Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition.

E-pub date: 12 Nov 2014


Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells.

E-pub date: 03 Nov 2014


Chemical biology of genomic DNA: minimizing PCR bias.

E-pub date: 18 Oct 2014


Nucleotide contributions to the structural integrity and DNA replication initiation activity of noncoding y RNA.

E-pub date: 23 Sep 2014


Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues.

E-pub date: 31 Aug 2014


Chemical biology on the genome.

E-pub date: 15 Aug 2014


Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution.

E-pub date: 31 May 2014


G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation.

E-pub date: 31 May 2014


Addendum: Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution.

E-pub date: 21 May 2014


Reprogramming the mechanism of action of chlorambucil by coupling to a G-quadruplex ligand.

E-pub date: 23 Apr 2014


Existence and consequences of G-quadruplex structures in DNA.

E-pub date: 01 Apr 2014


Targeting a c-MYC G-quadruplex DNA with a fragment library.

E-pub date: 18 Feb 2014


Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

E-pub date: 31 Jan 2014


Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins.

E-pub date: 31 Dec 2013


Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle.

E-pub date: 23 Dec 2013


Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine.

E-pub date: 31 Oct 2013


Mechanochemical properties of individual human telomeric RNA (TERRA) G-quadruplexes.

E-pub date: 11 Oct 2013


Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand.

E-pub date: 04 Oct 2013


G-quadruplex structures are stable and detectable in human genomic DNA.

E-pub date: 31 Aug 2013


A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation.

E-pub date: 31 Aug 2013


G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells.

E-pub date: 03 Jul 2013


Quantitative visualization of DNA G-quadruplex structures in human cells.

E-pub date: 31 Mar 2013


Downregulation of androgen receptor transcription by promoter g-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer.

E-pub date: 26 Feb 2013


An acetylene-bridged 6,8-purine dimer as a fluorescent switch-on probe for parallel G-quadruplexes.

E-pub date: 28 Jan 2013


Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells.

E-pub date: 24 Jan 2013


An RNA hairpin to G-quadruplex conformational transition.

E-pub date: 12 Dec 2012


The kinetics and folding pathways of intramolecular G-quadruplex nucleic acids.

E-pub date: 21 Nov 2012


Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry.

E-pub date: 29 Oct 2012


Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells.

E-pub date: 28 Aug 2012


Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase.

E-pub date: 17 Aug 2012


An intramolecular G-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2.

E-pub date: 25 Jul 2012


5′-UTR RNA G-quadruplexes: translation regulation and targeting.

E-pub date: 01 Jun 2012


Experimental approaches to identify cellular G-quadruplex structures and functions.

E-pub date: 31 May 2012


Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution.

E-pub date: 18 May 2012


Comparative structural effects of HIV-1 Gag and nucleocapsid proteins in binding to and unwinding of the viral RNA packaging signal.

E-pub date: 17 Apr 2012


A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro.

E-pub date: 01 Feb 2012


FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA.

E-pub date: 01 Feb 2012


Demonstration of ligand decoration, and ligand-induced perturbation, of G-quadruplexes in a plasmid using atomic force microscopy.

E-pub date: 17 Jan 2012


Synthesis of bis-indole carboxamides as G-quadruplex stabilizing and inducing ligands.

E-pub date: 09 Jan 2012


Decoding genomes at high speed: implications for science and medicine.

E-pub date: 23 Dec 2011


A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing.

E-pub date: 06 Sep 2011


A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.

E-pub date: 28 Aug 2011


A sequence-independent analysis of the loop length dependence of intramolecular RNA G-quadruplex stability and topology.

E-pub date: 23 Aug 2011


The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.

E-pub date: 21 Aug 2011


Sequencing nucleic acids: from chemistry to medicine.

E-pub date: 14 Jul 2011


Synthesis and binding studies of novel diethynyl-pyridine amides with genomic promoter DNA G-quadruplexes.

E-pub date: 11 Apr 2011


Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

E-pub date: 01 Apr 2011


G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells.

E-pub date: 02 Mar 2011


Small-molecule-mediated G-quadruplex isolation from human cells.

E-pub date: 31 Dec 2010


Distinct functions of maternal and somatic Pat1 protein paralogs.

E-pub date: 01 Nov 2010


Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines.

E-pub date: 14 Oct 2010


The BCL-2 5′ untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression.

E-pub date: 28 Sep 2010


Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.

E-pub date: 21 Jun 2010


RNA conformation in catalytically active human telomerase.

E-pub date: 10 Mar 2010


Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes.

E-pub date: 14 Feb 2010


Single-molecule analysis of the human telomerase RNA.dyskerin interaction and the effect of dyskeratosis congenita mutations.

E-pub date: 24 Nov 2009


Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression.

E-pub date: 01 Nov 2009


LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans.

E-pub date: 31 Oct 2009


A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.

E-pub date: 23 Sep 2009


A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression.

E-pub date: 09 Sep 2009


G-quadruplex DNA bound by a synthetic ligand is highly dynamic.

E-pub date: 09 Sep 2009


G-quadruplex nucleic acids as therapeutic targets.

E-pub date: 01 Jun 2009


Controlled-folding of a small molecule modulates DNA G-quadruplex recognition.

E-pub date: 07 Jan 2009


Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates.

E-pub date: 07 Jan 2009


FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts.

E-pub date: 26 Dec 2008


Position and stability are determining factors for translation repression by an RNA G-quadruplex-forming sequence within the 5′ UTR of the NRAS proto-oncogene.

E-pub date: 02 Dec 2008


Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes.

E-pub date: 26 Nov 2008


A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.

E-pub date: 26 Nov 2008


Accurate whole human genome sequencing using reversible terminator chemistry.

E-pub date: 06 Nov 2008


G-quadruplexes: the beginning and end of UTRs.

E-pub date: 01 Nov 2008


Selective recognition of a DNA G-quadruplex by an engineered antibody.

E-pub date: 09 Sep 2008


Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry.

E-pub date: 31 Aug 2008


Single molecule conformational analysis of DNA G-quadruplexes.

E-pub date: 31 Aug 2008


G-quadruplex recognition by bis-indole carboxamides.

E-pub date: 14 Jul 2008


Single-molecule analysis of human telomerase monomer.

E-pub date: 31 May 2008


Rigid cyanine dye nucleic acid labels.

E-pub date: 07 May 2008


Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC.

E-pub date: 07 May 2008


Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition.

E-pub date: 28 Mar 2008


A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes.

E-pub date: 15 Jan 2008


Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression.

E-pub date: 31 Oct 2007


Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands.

E-pub date: 03 Oct 2007


Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction.

E-pub date: 31 Aug 2007


Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit.

E-pub date: 20 Jun 2007


An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation.

E-pub date: 01 Apr 2007


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Research Integrity Conflict of Interest Disclosure: 
Last revised: 
12/09/2018
Company Active Research funding Ownership Royalty payments Commitment to carry out work for a fee Ad hoc reimbursed work Travel Gifts/ other
Cambridge Epigenetix Limited Yes No Yes No Yes No No No
Ahren Innovation Capital Yes No Yes No Yes No No No
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