Senior group leader

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Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE

TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions.

E-pub date: 31 Jan 2021

Landscape of G-quadruplex DNA structural regions in breast cancer.

E-pub date: 31 Jul 2020

Single-molecule visualization of DNA G-quadruplex formation in live cells.

E-pub date: 30 Jun 2020

Genome-wide DNA methylation signatures are determined by DNMT3A/B sequence preferences.

E-pub date: 31 May 2020

Affinity-selected bicyclic peptide G-quadruplex ligands mimic a protein-like binding mechanism.

E-pub date: 31 Mar 2020

The regulation and functions of DNA and RNA G-quadruplexes.

E-pub date: 31 Mar 2020

Natural, modified DNA bases.

E-pub date: 29 Feb 2020

The Structure and Function of DNA G-Quadruplexes

E-pub date: 31 Jan 2020

A Spontaneous Ring Opening Reaction Leads to a Repair-Resistant T Oxidation Product in Genomic DNA.

E-pub date: 31 Jul 2019

An activatable cancer-targeted hydrogen peroxide probe for photoacoustic and fluorescence imaging.

E-pub date: 31 Jul 2019

Unusual Activity of a Chlamydomonas TET/JBP Family Enzyme.

E-pub date: 31 Jul 2019

Genetic interactions of G-quadruplexes in humans.

E-pub date: 30 Jun 2019

Sequencing abasic sites in DNA at single-nucleotide resolution.

E-pub date: 31 May 2019

Correction to: RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs.

E-pub date: 31 May 2019

Publisher Correction: DNA sequencing at 40: past, present and future.

E-pub date: 31 Mar 2019

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.

E-pub date: 31 Mar 2019

Whole genome experimental maps of DNA G-quadruplexes in multiple species.

E-pub date: 28 Feb 2019

The detection, structure and function of modified DNA bases.

E-pub date: 28 Feb 2019

A Photo-responsive Small-Molecule Approach for the Opto-epigenetic Modulation of DNA Methylation.

E-pub date: 31 Jan 2019

Correction to: RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs.

E-pub date: 31 Dec 2018

Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.

E-pub date: 30 Nov 2018

RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs.

E-pub date: 30 Nov 2018

DNA G-quadruplex structures mold the DNA methylome.

E-pub date: 30 Sep 2018

5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells.

E-pub date: 30 Sep 2018

Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts.

E-pub date: 31 Aug 2018

Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome.

E-pub date: 02 Jul 2018

Sequencing 5-Hydroxymethyluracil at Single-Base Resolution

E-pub date: 30 Jun 2018

Sequencing 5-Hydroxymethyluracil at Single-Base Resolution.

E-pub date: 07 Jun 2018

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.

E-pub date: 01 Jun 2018

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence.

E-pub date: 09 May 2018

Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing.

E-pub date: 31 Mar 2018

Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule.

E-pub date: 22 Mar 2018

Synthesis and Multiple Incorporations of 2′-O-Methyl-5-hydroxymethylcytidine, 5-Hydroxymethylcytidine and 5-Formylcytidine Monomers into RNA Oligonucleotides.

E-pub date: 16 Nov 2017

Machine learning model for sequence-driven DNA G-quadruplex formation.

E-pub date: 06 Nov 2017

Local epigenetic reprogramming induced by G-quadruplex ligands.

E-pub date: 01 Nov 2017

DNA sequencing at 40: past, present and future.

E-pub date: 30 Sep 2017

Mapping and elucidating the function of modified bases in DNA

E-pub date: 01 Sep 2017

Base resolution maps reveal the importance of 5-hydroxymethylcytosine in a human glioblastoma.

E-pub date: 31 Aug 2017

Therapeutics: Click and discover.

E-pub date: 09 Aug 2017

The Profile and Dynamics of RNA Modifications in Animals.

E-pub date: 01 Jun 2017

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential.

E-pub date: 31 May 2017

Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications.

E-pub date: 04 May 2017

G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition.

E-pub date: 31 Mar 2017

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

E-pub date: 17 Feb 2017

2′-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA.

E-pub date: 08 Feb 2017

Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming.

E-pub date: 31 Jan 2017

Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite Leishmania.

E-pub date: 30 Jan 2017

Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides.

E-pub date: 24 Jan 2017

Single genome retrieval of context-dependent variability in mutation rates for human germline.

E-pub date: 13 Jan 2017

Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing.

E-pub date: 02 Nov 2016

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome.

E-pub date: 31 Oct 2016

DSBCapture: in situ capture and sequencing of DNA breaks.

E-pub date: 31 Oct 2016

G-quadruplex structures mark human regulatory chromatin.

E-pub date: 31 Oct 2016

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.

E-pub date: 25 Oct 2016

An Epigenetics-Inspired DNA-Based Data Storage System.

E-pub date: 05 Sep 2016

Enhanced Methylation Analysis by Recovery of Unsequenceable Fragments.

E-pub date: 31 Aug 2016

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA.

E-pub date: 25 Jul 2016

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA

E-pub date: 30 Jun 2016

In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine.

E-pub date: 29 Jun 2016

Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases.

E-pub date: 12 Mar 2016

Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes.

E-pub date: 27 Jan 2016

Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies.

E-pub date: 10 Nov 2015

High-throughput sequencing of DNA G-quadruplex structures in the human genome.

E-pub date: 31 Aug 2015

Accurate measurement of 5-methylcytosine and 5-hydroxymethylcytosine in human cerebellum DNA by oxidative bisulfite on an array (OxBS-array).

E-pub date: 31 Aug 2015

5-Formylcytosine can be a stable DNA modification in mammals.

E-pub date: 31 Aug 2015

Selective Chemical Labeling of Natural T Modifications in DNA.

E-pub date: 29 Jul 2015

FOXM1 binds directly to non-consensus sequences in the human genome.

E-pub date: 23 Jun 2015

Targeted Detection of G-Quadruplexes in Cellular RNAs.

E-pub date: 01 Jun 2015

G-quadruplex ligands exhibit differential G-tetrad selectivity.

E-pub date: 11 May 2015

Chemical methods for decoding cytosine modifications in DNA.

E-pub date: 25 Mar 2015

Formation and abundance of 5-hydroxymethylcytosine in RNA.

E-pub date: 23 Mar 2015

Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase.

E-pub date: 27 Feb 2015

Decoding genomes.

E-pub date: 01 Feb 2015

5-Formylcytosine alters the structure of the DNA double helix.

E-pub date: 31 Jan 2015

Solexa sequencing: decoding genomes on a population scale.

E-pub date: 31 Jan 2015

oxBS-450K: a method for analysing hydroxymethylation using 450K BeadChips.

E-pub date: 15 Jan 2015

Dual binding of an antibody and a small molecule increases the stability of TERRA G-quadruplex.

E-pub date: 12 Jan 2015

Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex.

E-pub date: 12 Jan 2015

The biology and genomic localization of cytosine modifications

E-pub date: 31 Dec 2014

5-Hydroxymethylcytosine is a predominantly stable DNA modification.

E-pub date: 31 Dec 2014

Targeting DNA G-quadruplexes with helical small molecules.

E-pub date: 24 Nov 2014

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition.

E-pub date: 12 Nov 2014

Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells.

E-pub date: 03 Nov 2014

Chemical biology of genomic DNA: minimizing PCR bias.

E-pub date: 18 Oct 2014

Nucleotide contributions to the structural integrity and DNA replication initiation activity of noncoding y RNA.

E-pub date: 23 Sep 2014

Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues.

E-pub date: 31 Aug 2014

Chemical biology on the genome.

E-pub date: 15 Aug 2014

Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences.

E-pub date: 31 May 2014

Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution.

E-pub date: 31 May 2014

G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation.

E-pub date: 31 May 2014

Addendum: Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution.

E-pub date: 21 May 2014

Reprogramming the mechanism of action of chlorambucil by coupling to a G-quadruplex ligand.

E-pub date: 23 Apr 2014

Existence and consequences of G-quadruplex structures in DNA.

E-pub date: 01 Apr 2014

Targeting a c-MYC G-quadruplex DNA with a fragment library.

E-pub date: 18 Feb 2014

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

E-pub date: 31 Jan 2014

Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins.

E-pub date: 31 Dec 2013

Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle.

E-pub date: 23 Dec 2013

Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine.

E-pub date: 31 Oct 2013

Mechanochemical properties of individual human telomeric RNA (TERRA) G-quadruplexes.

E-pub date: 11 Oct 2013

Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand.

E-pub date: 04 Oct 2013

G-quadruplex structures are stable and detectable in human genomic DNA.

E-pub date: 31 Aug 2013

A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation.

E-pub date: 31 Aug 2013

G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells.

E-pub date: 03 Jul 2013

Quantitative visualization of DNA G-quadruplex structures in human cells.

E-pub date: 31 Mar 2013

Downregulation of androgen receptor transcription by promoter g-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer.

E-pub date: 26 Feb 2013

An acetylene-bridged 6,8-purine dimer as a fluorescent switch-on probe for parallel G-quadruplexes.

E-pub date: 28 Jan 2013

Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells.

E-pub date: 24 Jan 2013

An RNA hairpin to G-quadruplex conformational transition.

E-pub date: 12 Dec 2012

The kinetics and folding pathways of intramolecular G-quadruplex nucleic acids.

E-pub date: 21 Nov 2012

Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry.

E-pub date: 29 Oct 2012

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells.

E-pub date: 28 Aug 2012

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase.

E-pub date: 17 Aug 2012

An intramolecular G-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2.

E-pub date: 25 Jul 2012

5′-UTR RNA G-quadruplexes: translation regulation and targeting.

E-pub date: 01 Jun 2012

Experimental approaches to identify cellular G-quadruplex structures and functions.

E-pub date: 31 May 2012

Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution.

E-pub date: 18 May 2012

Comparative structural effects of HIV-1 Gag and nucleocapsid proteins in binding to and unwinding of the viral RNA packaging signal.

E-pub date: 17 Apr 2012

A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro.

E-pub date: 01 Feb 2012

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA.

E-pub date: 01 Feb 2012

Demonstration of ligand decoration, and ligand-induced perturbation, of G-quadruplexes in a plasmid using atomic force microscopy.

E-pub date: 17 Jan 2012

Synthesis of bis-indole carboxamides as G-quadruplex stabilizing and inducing ligands.

E-pub date: 09 Jan 2012

Decoding genomes at high speed: implications for science and medicine.

E-pub date: 23 Dec 2011

Erratum: The transcription factor FOXM1 is a cellular target of the natural product thiostrepton (Nature Chemistry (2011) 3 (725-731))

E-pub date: 30 Sep 2011

A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing.

E-pub date: 06 Sep 2011

A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.

E-pub date: 28 Aug 2011

A sequence-independent analysis of the loop length dependence of intramolecular RNA G-quadruplex stability and topology.

E-pub date: 23 Aug 2011

The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.

E-pub date: 21 Aug 2011

Sequencing nucleic acids: from chemistry to medicine.

E-pub date: 14 Jul 2011

Synthesis and binding studies of novel diethynyl-pyridine amides with genomic promoter DNA G-quadruplexes.

E-pub date: 11 Apr 2011

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

E-pub date: 01 Apr 2011

Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae

E-pub date: 31 Mar 2011

G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells.

E-pub date: 02 Mar 2011

Small-molecule-mediated G-quadruplex isolation from human cells.

E-pub date: 31 Dec 2010

Erratum: Targeting the c-kit promoter G-quadruplexes with 6-substituted indenoisoquinolines (ACS Medicinal Chemistry Letters (2010) 1 (306) DOI: 10.1021/ml100062z)

E-pub date: 30 Nov 2010

Distinct functions of maternal and somatic Pat1 protein paralogs.

E-pub date: 01 Nov 2010

Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines.

E-pub date: 14 Oct 2010

Diversity of human copy number variation and multicopy genes.

E-pub date: 30 Sep 2010

The BCL-2 5′ untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression.

E-pub date: 28 Sep 2010

Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.

E-pub date: 21 Jun 2010

RNA conformation in catalytically active human telomerase.

E-pub date: 10 Mar 2010

Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes.

E-pub date: 14 Feb 2010

Single-molecule analysis of the human telomerase RNA.dyskerin interaction and the effect of dyskeratosis congenita mutations.

E-pub date: 24 Nov 2009

Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression.

E-pub date: 01 Nov 2009

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans.

E-pub date: 31 Oct 2009

A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.

E-pub date: 23 Sep 2009

A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression.

E-pub date: 09 Sep 2009

G-quadruplex DNA bound by a synthetic ligand is highly dynamic.

E-pub date: 09 Sep 2009

G-quadruplex nucleic acids as therapeutic targets.

E-pub date: 01 Jun 2009

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition.

E-pub date: 07 Jan 2009

Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates.

E-pub date: 07 Jan 2009

FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts.

E-pub date: 26 Dec 2008

Position and stability are determining factors for translation repression by an RNA G-quadruplex-forming sequence within the 5′ UTR of the NRAS proto-oncogene.

E-pub date: 02 Dec 2008

Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes.

E-pub date: 26 Nov 2008

A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.

E-pub date: 26 Nov 2008

Accurate whole human genome sequencing using reversible terminator chemistry.

E-pub date: 06 Nov 2008

G-quadruplexes: the beginning and end of UTRs.

E-pub date: 01 Nov 2008

Selective recognition of a DNA G-quadruplex by an engineered antibody.

E-pub date: 09 Sep 2008

Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry.

E-pub date: 31 Aug 2008

Single molecule conformational analysis of DNA G-quadruplexes.

E-pub date: 31 Aug 2008

G-quadruplex recognition by bis-indole carboxamides.

E-pub date: 14 Jul 2008

Single-molecule analysis of human telomerase monomer (vol 4, pg 287, 2008)

E-pub date: 01 Jun 2008

Single-molecule analysis of human telomerase monomer.

E-pub date: 31 May 2008

Rigid cyanine dye nucleic acid labels.

E-pub date: 07 May 2008

Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC.

E-pub date: 07 May 2008

Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition.

E-pub date: 28 Mar 2008

A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes.

E-pub date: 15 Jan 2008

Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression.

E-pub date: 31 Oct 2007

Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands.

E-pub date: 03 Oct 2007

Ligand-driven G-quadruplex conformational switching by using an unusual mode of interaction.

E-pub date: 31 Aug 2007

Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit.

E-pub date: 20 Jun 2007

An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation.

E-pub date: 01 Apr 2007

Erratum: G-quadruplexes in promoters throughout the human genome (Nucleic Acids Research (2007) vol. 35 (406-413) 10.1093/nar/gkl1057)

E-pub date: 28 Feb 2007

A Simple Nanomixer for Single-Molecule Kinetics Measurements

E-pub date: 31 Oct 2006

Individual Molecules of Dye-Labeled DNA Act as a Reversible Two-Color Switch upon Application of an Electric Field

E-pub date: 31 Oct 2004

Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation.

E-pub date: 31 Oct 2003

Recent developments in linker design and application.

E-pub date: 01 Jun 2003

Ultrasensitive coincidence fluorescence detection of single DNA molecules.

E-pub date: 31 Mar 2003

Site-specific cleavage of human telomerase RNA using PNA-neocuproine.Zn(II) derivatives.

E-pub date: 31 Dec 2002

Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro.

E-pub date: 30 Sep 2002

Synthesis of a polymer-supported oxazolidine aldehyde for asymmetric chemistry.

E-pub date: 31 Aug 2002

Enhanced cooperative binding of oligonucleotides to form DNA duplexes mediated by metal ion chelation.

E-pub date: 31 Aug 2002

Solid-phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates.

E-pub date: 30 Jun 2002

Studies on the chemical stability and functional group compatibility of the benzoin photolabile safety-catch linker using an analytical construct.

E-pub date: 01 Jan 2002

Practical synthesis of a dithiane-protected 3′,5′-dialkoxybenzoin photolabile safety-catch linker for solid-phase organic synthesis.

E-pub date: 31 Dec 2001

Selection of zinc fingers that bind single-stranded telomeric DNA in the G-quadruplex conformation.

E-pub date: 31 Dec 2000

Exploring a benzyloxyaniline linker utilizing ceric ammonium nitrate (CAN) as a cleavage reagent: solid-phase synthesis of N-unsubstituted beta-lactams and secondary amides.

E-pub date: 31 Dec 2000

The science of chemical discovery: probing the unknown with new technologies.

E-pub date: 30 Nov 2000

Single-molecule analysis of DNA immobilized on microspheres.

E-pub date: 31 Jul 2000

Strategies for the synthesis of fluorescently labelled PNA.

E-pub date: 31 Jul 2000

Recent developments in the encoding and deconvolution of combinatorial libraries.

E-pub date: 01 Jun 2000

Solid-phase synthesis of N-alkyl-N-(beta-keto)amides and 1,2,4,5-tetrasubstituted imidazoles using a traceless cleavage strategy

E-pub date: 31 Jan 2000

Screening for oligonucleotide binding affinity by a convenient fluorescence competition assay.

E-pub date: 31 Aug 1999

Exploring a chemical encoding strategy for combinatorial synthesis using Friedel-Crafts alkylation.

E-pub date: 01 Aug 1999

Studies on a Dithiane-Protected Benzoin Photolabile Safety Catch Linker for Solid-Phase Synthesis.

E-pub date: 30 Apr 1999

Inhibition of human telomerase by PNA-cationic peptide conjugates.

E-pub date: 30 Apr 1999

Synthesis and hybridization analysis of a small library of peptide-oligonucleotide conjugates.

E-pub date: 30 Jun 1998

Escherichia coli chorismate synthase catalyzes the conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate. Implications for the enzyme mechanism and the antimicrobial action of (6S)-6-fluoroshikimate.

E-pub date: 31 Aug 1995

Mechanism of metal-independent hydroxylation by Chromobacterium violaceum phenylalanine hydroxylase.

E-pub date: 31 May 1995

Escherichia coli chorismate synthase: a deuterium kinetic-isotope effect under single-turnover and steady-state conditions shows that a flavin intermediate forms before the C-(6proR)-H bond is cleaved.

E-pub date: 31 Jan 1995

Observation of a secondary tritium isotope effect in the chorismate synthase reaction.

E-pub date: 31 Dec 1994

Recombinant HIV-1 nucleocapsid protein accelerates HIV-1 reverse transcriptase catalyzed DNA strand transfer reactions and modulates RNase H activity.

E-pub date: 31 Oct 1994

Identification of metal ligands in Cu(II)-inhibited Chromobacterium violaceum phenylalanine hydroxylase by electron spin echo envelope modulation analysis of histidine to serine mutations.

E-pub date: 30 Jun 1994

Observation of an Isotope Effect in the Chorismate Synthase Reaction

E-pub date: 31 Dec 1989

Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis

E-pub date: 01 Jan 1970

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