Senior Group Leader

Research Group Home Page: 
Rosenfeld Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Measurement of plasma cell-free mitochondrial tumor DNA improves detection of glioblastoma in patient-derived orthotopic xenograft models.

E-pub date: 31 Oct 2018


Enhanced detection of circulating tumor DNA by fragment size analysis.

E-pub date: 31 Oct 2018


Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients.

E-pub date: 31 Oct 2018


Effects of collection and processing procedures on plasma circulating cell-free DNA from cancer patients.

E-pub date: 31 Jul 2018


Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer.

E-pub date: 01 Jun 2018


Development of a highly sensitive liquid biopsy platform to detect clinically-relevant cancer mutations at low allele fractions in cell-free DNA.

E-pub date: 16 Mar 2018


Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling.

E-pub date: 15 Mar 2018


Tracking evolution of aromatase inhibitor resistance with circulating tumour DNA analysis in metastatic breast cancer.

E-pub date: 01 Jan 2018


Are liquid biopsies a surrogate for tissue EGFR testing?

E-pub date: 01 Jan 2018


Societal challenges of precision medicine: Bringing order to chaos.

E-pub date: 31 Oct 2017


Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer.

E-pub date: 17 Jul 2017


CVE: an R package for interactive variant prioritisation in precision oncology.

E-pub date: 25 May 2017


Liquid biopsies come of age: towards implementation of circulating tumour DNA.

E-pub date: 01 Apr 2017


Osimertinib benefit in EGFR-mutant NSCLC patients with T790M-mutation detected by circulating tumour DNA.

E-pub date: 01 Apr 2017


Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study.

E-pub date: 31 Dec 2016


Optimized p53 immunohistochemistry is an accurate predictor of TP53 mutation in ovarian carcinoma.

E-pub date: 31 Oct 2016


Consensus on precision medicine for metastatic cancers: a report from the MAP conference.

E-pub date: 31 Aug 2016


Erratum: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes.

E-pub date: 06 Jun 2016


The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.

E-pub date: 10 May 2016


Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.

E-pub date: 04 Nov 2015


Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.

E-pub date: 01 Apr 2015


Circulating tumor-derived DNA is shorter than somatic DNA in plasma.

E-pub date: 17 Mar 2015


Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis.

E-pub date: 01 Feb 2015


Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.

E-pub date: 31 Aug 2014


PTU-153 The Timing Of Oncogenic Events In The Evolution Of The Oesophageal Adenocarcinoma Genome And Implications For Clinical Diagnostics.

E-pub date: 01 Jun 2014


Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma.

E-pub date: 31 Jan 2014


EGFR exon 20 insertion A763-Y764insFQEA and response to erlotinib–Letter.

E-pub date: 01 Nov 2013


Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.

E-pub date: 01 Sep 2013


Circulating tumor DNA to monitor metastatic breast cancer.

E-pub date: 04 Jul 2013


Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA.

E-pub date: 02 May 2013


Analysis of circulating tumor DNA to monitor metastatic breast cancer.

E-pub date: 28 Mar 2013


Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA.

E-pub date: 30 May 2012


Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy.

E-pub date: 15 Dec 2011


MicroRNAs as a potential prognostic factor in gastric cancer.

E-pub date: 21 Sep 2011


A diagnostic assay based on microRNA expression accurately identifies malignant pleural mesothelioma.

E-pub date: 01 Nov 2010


Accurate molecular classification of renal tumors using microRNA expression.

E-pub date: 01 Sep 2010


Differential diagnosis of hepatocellular carcinoma from metastatic tumors in the liver using microRNA expression.

E-pub date: 31 Aug 2010


Validation of a microRNA-based qRT-PCR test for accurate identification of tumor tissue origin.

E-pub date: 01 Jun 2010


MiR-92b and miR-9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors.

E-pub date: 31 Jul 2009


Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma.

E-pub date: 20 Apr 2009


MicroRNAs accurately identify cancer tissue origin.

E-pub date: 01 Apr 2008


Accurate prediction of gene feedback circuit behavior from component properties.

E-pub date: 31 Aug 2007


Transcriptional activation of miR-34a contributes to p53-mediated apoptosis.

E-pub date: 08 Jun 2007


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