Head of Molecular Imaging

Research Group Home Page: 

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo.

E-pub date: 31 Aug 2018


Thymidine Metabolism as a Confounding Factor for 3′-Deoxy-3′-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model.

E-pub date: 31 Jul 2018


Depicting changes in tumor biology in response to cetuximab mono- or combination therapy by apoptosis and proliferation imaging using 18F-ICMT-11 and 3′-Deoxy-3′-[18F]Fluorothymidine (18F-FLT) PET.

E-pub date: 24 May 2018


3′-Deoxy-3′-[18F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models.

E-pub date: 01 Apr 2018


Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

E-pub date: 15 Dec 2017


Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.

E-pub date: 24 Oct 2017


Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.

E-pub date: 31 Aug 2017


The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox.

E-pub date: 31 Aug 2017


Exploration of human brain tumour metabolism using pairwise metabolite-metabolite correlation analysis (MMCA) of HR-MAS 1H NMR spectra.

E-pub date: 31 Aug 2017


Assessment of early treatment response to neoadjuvant chemotherapy in breast cancer using non-mono-exponential diffusion models: a feasibility study comparing the baseline and mid-treatment MRI examinations.

E-pub date: 31 Jul 2017


Quantitative and textural analysis of magnetization transfer and diffusion images in the early detection of brain metastases.

E-pub date: 31 May 2017


Imaging biomarker roadmap for cancer studies.

E-pub date: 31 Mar 2017


The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.

E-pub date: 31 Dec 2016


Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3′-Deoxy-3′-[18F]Fluorothymidine in Preclinical Models of Lung Cancer.

E-pub date: 15 Dec 2016


S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.

E-pub date: 08 Dec 2016


Response of Degarelix treatment in human prostate cancer monitored by HR-MAS 1H NMR spectroscopy.

E-pub date: 31 Aug 2016


A study of the optical and polarisation properties of InGaN/GaN multiple quantum wells grown on a-plane and m-plane GaN substrates.

E-pub date: 31 Aug 2016


Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.

E-pub date: 31 May 2016


Effect of Radiofrequency Transmit Field Correction on Quantitative Dynamic Contrast-enhanced MR Imaging of the Breast at 3.0 T.

E-pub date: 31 May 2016


Multi-institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion-weighted MRI.

E-pub date: 01 Apr 2016


Multimodal MRI can identify perfusion and metabolic changes in the invasive margin of glioblastomas.

E-pub date: 01 Feb 2016


Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor study.

E-pub date: 31 Dec 2015


Classification of brain tumours from MR spectra: the INTERPRET collaboration and its outcomes.

E-pub date: 31 Dec 2015


Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression.

E-pub date: 31 Aug 2015


Artefacts in 1H NMR-based metabolomic studies on cell cultures.

E-pub date: 01 Apr 2015


Normalization of metabolomics data with applications to correlation maps.

E-pub date: 01 Aug 2014


Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.

E-pub date: 15 Jul 2014


Dichloroacetate induces autophagy in colorectal cancer cells and tumours.

E-pub date: 15 Jul 2014


Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.

E-pub date: 17 Jun 2014


Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3′-Deoxy-3′-¹⁸F-Fluorothymidine PET and Diffusion-Weighted MR Imaging.

E-pub date: 01 Jun 2014


Muscle metabolism and activation heterogeneity by combined 31P chemical shift and T2 imaging, and pulmonary O2 uptake during incremental knee-extensor exercise.

E-pub date: 01 Sep 2013


Evaluation and immunohistochemical qualification of carbogen-induced ΔR₂ as a noninvasive imaging biomarker of improved tumor oxygenation.

E-pub date: 01 Sep 2013


Noninvasive phosphorus magnetic resonance spectroscopic imaging predicts outcome to first-line chemotherapy in newly diagnosed patients with diffuse large B-cell lymphoma.

E-pub date: 01 Sep 2013


Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome.

E-pub date: 01 Feb 2013


Repeatability of edited lactate and other metabolites in astrocytoma at 3T.

E-pub date: 31 Aug 2012


Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin.

E-pub date: 24 Jul 2012


Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.

E-pub date: 23 May 2012


Advanced ovarian cancer: multiparametric MR imaging demonstrates response- and metastasis-specific effects.

E-pub date: 01 Apr 2012


Prospective diagnostic performance evaluation of single-voxel 1H MRS for typing and grading of brain tumours.

E-pub date: 01 Apr 2012


Magnetic resonance spectroscopy of cancer metabolism and response to therapy.

E-pub date: 01 Apr 2012


DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: a feasibility study.

E-pub date: 31 Mar 2012


Histone deacetylase inhibition increases levels of choline kinase α and phosphocholine facilitating noninvasive imaging in human cancers.

E-pub date: 15 Feb 2012


A novel method for quantification of gemcitabine and its metabolites 2′,2′-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.

E-pub date: 01 Nov 2011


Non-invasive grading of astrocytic tumours from the relative contents of myo-inositol and glycine measured by in vivo MRS.

E-pub date: 01 Nov 2011


Incremental Gaussian Discriminant Analysis based on Graybill and Deal weighted combination of estimators for brain tumour diagnosis.

E-pub date: 31 Aug 2011


Can localised (19)F magnetic resonance spectroscopy pharmacokinetics of 5FU in colorectal metastases predict clinical response?

E-pub date: 31 Jul 2011


MRI & MRS assessment of the role of the tumour microenvironment in response to therapy.

E-pub date: 31 Jul 2011


Metabolic homeostasis is maintained in myocardial hibernation by adaptive changes in the transcriptome and proteome.

E-pub date: 01 Jun 2011


Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas.

E-pub date: 25 May 2011


Prostate cancer metabolite quantification relative to water in (1)H-MRSI in vivo at 3 Tesla.

E-pub date: 16 Nov 2010


Combined use of neuroradiology and 1H-MR spectroscopy may provide an intervention limiting diagnosis of glioblastoma multiforme.

E-pub date: 01 Nov 2010


Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

E-pub date: 01 Oct 2010


The altered metabolism of tumors: HIF-1 and its role in the Warburg effect.

E-pub date: 31 Aug 2010


Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts.

E-pub date: 01 Aug 2010


Dynamic contrast-enhanced MRI in ovarian cancer: Initial experience at 3 tesla in primary and metastatic disease.

E-pub date: 01 Apr 2010


Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers.

E-pub date: 23 Mar 2010


Apparent diffusion coefficient and vascular signal fraction measurements with magnetic resonance imaging: feasibility in metastatic ovarian cancer at 3 Tesla: technical development.

E-pub date: 01 Feb 2010


Correlations between in vivo (1)H MRS and ex vivo (1)H HRMAS metabolite measurements in adult human gliomas.

E-pub date: 01 Feb 2010


Tri-partite complex for axonal transport drug delivery achieves pharmacological effect.

E-pub date: 20 Jan 2010


Pattern recognition of MRSI data shows regions of glioma growth that agree with DTI markers of brain tumor infiltration.

E-pub date: 31 Dec 2009


Metabolic characterization of primary and metastatic ovarian cancer by 1H-MRS in vivo at 3T.

E-pub date: 31 Oct 2009


Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques.

E-pub date: 31 Aug 2009


Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.

E-pub date: 12 Jun 2009


In vivo 31P magnetic resonance spectroscopy using a needle microcoil.

E-pub date: 31 May 2009


Taurine: a potential marker of apoptosis in gliomas.

E-pub date: 10 Mar 2009


Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts.

E-pub date: 01 Feb 2009


Longitudinal in vivo susceptibility contrast MRI measurements of LS174T colorectal liver metastasis in nude mice.

E-pub date: 31 Dec 2008


Effect of Gd-DTPA-BMA on choline signals of HT29 tumors detected by in vivo 1H MRS.

E-pub date: 01 Nov 2008


Toward accurate quantification of metabolites, lipids, and macromolecules in HRMAS spectra of human brain tumor biopsies using LCModel.

E-pub date: 01 Nov 2008


An assessment of the effects of sample ischaemia and spinning time on the metabolic profile of brain tumour biopsy specimens as determined by high-resolution magic angle spinning (1)H NMR.

E-pub date: 01 Nov 2008


SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.

E-pub date: 01 Sep 2008


An investigation of human brain tumour lipids by high-resolution magic angle spinning 1H MRS and histological analysis.

E-pub date: 31 Aug 2008


Vessel size index magnetic resonance imaging to monitor the effect of antivascular treatment in a rodent tumor model.

E-pub date: 01 Aug 2008


Automated quality control protocol for MR spectra of brain tumors.

E-pub date: 01 Jun 2008


Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice.

E-pub date: 09 May 2008


Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts.

E-pub date: 01 Apr 2008


Combined metabolomic and proteomic analysis of human atrial fibrillation.

E-pub date: 05 Feb 2008


Apparent T(2) relaxation times of lipid and macromolecules: a study of high-grade tumor spectra.

E-pub date: 31 Jan 2008


Linear discriminant analysis of brain tumour (1)H MR spectra: a comparison of classification using whole spectra versus metabolite quantification.

E-pub date: 31 Dec 2007


Susceptibility contrast magnetic resonance imaging determination of fractional tumor blood volume: a noninvasive imaging biomarker of response to the vascular disrupting agent ZD6126.

E-pub date: 01 Nov 2007


Rat tumor response to the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid as measured by dynamic contrast-enhanced magnetic resonance imaging, plasma 5-hydroxyindoleacetic acid levels, and tumor necrosis.

E-pub date: 01 Mar 2006


Acute tumor response to ZD6126 assessed by intrinsic susceptibility magnetic resonance imaging.

E-pub date: 01 May 2005


Single dose of the antivascular agent, ZD6126 (N-acetylcolchinol-O-phosphate), reduces perfusion for at least 96 hours in the GH3 prolactinoma rat tumor model.

E-pub date: 01 Mar 2004


Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models.

E-pub date: 31 Oct 2003


Increased tumour extracellular pH induced by Bafilomycin A1 inhibits tumour growth and mitosis in vivo and alters 5-fluorouracil pharmacokinetics.

E-pub date: 01 Mar 2003


Understanding the tumor metabolic phenotype in the genomic era.

E-pub date: 01 Feb 2003


Issues in flow and oxygenation dependent contrast (FLOOD) imaging of tumours.

E-pub date: 01 Nov 2001


In-vivo intracellular pH at rest and during exercise in patients with essential hypertension.

E-pub date: 01 Sep 2001


In vivo hyperpolarized 129Xe NMR spectroscopy in tumors.

E-pub date: 01 Sep 2001


Issues of normal tissue toxicity in patient and animal studies–effect of carbogen breathing in rats after 5-fluorouracil treatment.

E-pub date: 01 Aug 2001


Measurement of the extracellular pH of solid tumours in mice by magnetic resonance spectroscopy: a comparison of exogenous (19)F and (31)P probes.

E-pub date: 01 Dec 1999


Continuing ischemic damage after acute middle cerebral artery infarction in humans demonstrated by short-echo proton spectroscopy.

E-pub date: 01 Jun 1995


Pharmacokinetic studies with the antifolate C2-desamino-C2-methyl-N10-propargyl-2′-trifluoromethyl-5,8-dideazafolic acid (CB3988) in mice and rats using in vivo 19F-NMR spectroscopy.

E-pub date: 01 Nov 1990


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Research Integrity Conflict of Interest Disclosure: 
Last revised: 
12/09/2018
Company Active Research funding Ownership Royalty payments Commitment to carry out work for a fee Ad hoc reimbursed work Travel Gifts/ other
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