Head of Molecular Imaging

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Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo.

E-pub date: 31 Aug 2018

Thymidine Metabolism as a Confounding Factor for 3′-Deoxy-3′-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model.

E-pub date: 31 Jul 2018

Depicting changes in tumor biology in response to cetuximab mono- or combination therapy by apoptosis and proliferation imaging using 18F-ICMT-11 and 3′-Deoxy-3′-[18F]Fluorothymidine (18F-FLT) PET.

E-pub date: 24 May 2018

3′-Deoxy-3′-[18F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models.

E-pub date: 01 Apr 2018

Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

E-pub date: 15 Dec 2017

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.

E-pub date: 24 Oct 2017

Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.

E-pub date: 31 Aug 2017

The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox.

E-pub date: 31 Aug 2017

Exploration of human brain tumour metabolism using pairwise metabolite-metabolite correlation analysis (MMCA) of HR-MAS 1H NMR spectra.

E-pub date: 31 Aug 2017

Assessment of early treatment response to neoadjuvant chemotherapy in breast cancer using non-mono-exponential diffusion models: a feasibility study comparing the baseline and mid-treatment MRI examinations.

E-pub date: 31 Jul 2017

Quantitative and textural analysis of magnetization transfer and diffusion images in the early detection of brain metastases.

E-pub date: 31 May 2017

Imaging biomarker roadmap for cancer studies.

E-pub date: 31 Mar 2017

The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.

E-pub date: 31 Dec 2016

Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3′-Deoxy-3′-[18F]Fluorothymidine in Preclinical Models of Lung Cancer.

E-pub date: 15 Dec 2016

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.

E-pub date: 08 Dec 2016

Response of Degarelix treatment in human prostate cancer monitored by HR-MAS 1H NMR spectroscopy.

E-pub date: 31 Aug 2016

A study of the optical and polarisation properties of InGaN/GaN multiple quantum wells grown on a-plane and m-plane GaN substrates.

E-pub date: 31 Aug 2016

Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.

E-pub date: 31 May 2016

Effect of Radiofrequency Transmit Field Correction on Quantitative Dynamic Contrast-enhanced MR Imaging of the Breast at 3.0 T.

E-pub date: 31 May 2016

Multi-institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion-weighted MRI.

E-pub date: 01 Apr 2016

Multimodal MRI can identify perfusion and metabolic changes in the invasive margin of glioblastomas.

E-pub date: 01 Feb 2016

Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor study.

E-pub date: 31 Dec 2015

Classification of brain tumours from MR spectra: the INTERPRET collaboration and its outcomes.

E-pub date: 31 Dec 2015

Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression.

E-pub date: 31 Aug 2015

Artefacts in 1H NMR-based metabolomic studies on cell cultures.

E-pub date: 01 Apr 2015

Normalization of metabolomics data with applications to correlation maps.

E-pub date: 01 Aug 2014

Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.

E-pub date: 15 Jul 2014

Dichloroacetate induces autophagy in colorectal cancer cells and tumours.

E-pub date: 15 Jul 2014

Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.

E-pub date: 17 Jun 2014

Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3′-Deoxy-3′-¹⁸F-Fluorothymidine PET and Diffusion-Weighted MR Imaging.

E-pub date: 01 Jun 2014

Muscle metabolism and activation heterogeneity by combined 31P chemical shift and T2 imaging, and pulmonary O2 uptake during incremental knee-extensor exercise.

E-pub date: 01 Sep 2013

Evaluation and immunohistochemical qualification of carbogen-induced ΔR₂ as a noninvasive imaging biomarker of improved tumor oxygenation.

E-pub date: 01 Sep 2013

Noninvasive phosphorus magnetic resonance spectroscopic imaging predicts outcome to first-line chemotherapy in newly diagnosed patients with diffuse large B-cell lymphoma.

E-pub date: 01 Sep 2013

Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome.

E-pub date: 01 Feb 2013

Repeatability of edited lactate and other metabolites in astrocytoma at 3T.

E-pub date: 31 Aug 2012

Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin.

E-pub date: 24 Jul 2012

Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.

E-pub date: 23 May 2012

Advanced ovarian cancer: multiparametric MR imaging demonstrates response- and metastasis-specific effects.

E-pub date: 01 Apr 2012

Prospective diagnostic performance evaluation of single-voxel 1H MRS for typing and grading of brain tumours.

E-pub date: 01 Apr 2012

Magnetic resonance spectroscopy of cancer metabolism and response to therapy.

E-pub date: 01 Apr 2012

DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: a feasibility study.

E-pub date: 31 Mar 2012

Histone deacetylase inhibition increases levels of choline kinase α and phosphocholine facilitating noninvasive imaging in human cancers.

E-pub date: 15 Feb 2012

A novel method for quantification of gemcitabine and its metabolites 2′,2′-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.

E-pub date: 01 Nov 2011

Non-invasive grading of astrocytic tumours from the relative contents of myo-inositol and glycine measured by in vivo MRS.

E-pub date: 01 Nov 2011

Incremental Gaussian Discriminant Analysis based on Graybill and Deal weighted combination of estimators for brain tumour diagnosis.

E-pub date: 31 Aug 2011

Can localised (19)F magnetic resonance spectroscopy pharmacokinetics of 5FU in colorectal metastases predict clinical response?

E-pub date: 31 Jul 2011

MRI & MRS assessment of the role of the tumour microenvironment in response to therapy.

E-pub date: 31 Jul 2011

Metabolic homeostasis is maintained in myocardial hibernation by adaptive changes in the transcriptome and proteome.

E-pub date: 01 Jun 2011

Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas.

E-pub date: 25 May 2011

Prostate cancer metabolite quantification relative to water in (1)H-MRSI in vivo at 3 Tesla.

E-pub date: 16 Nov 2010

Combined use of neuroradiology and 1H-MR spectroscopy may provide an intervention limiting diagnosis of glioblastoma multiforme.

E-pub date: 01 Nov 2010

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

E-pub date: 01 Oct 2010

The altered metabolism of tumors: HIF-1 and its role in the Warburg effect.

E-pub date: 31 Aug 2010

Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts.

E-pub date: 01 Aug 2010

Dynamic contrast-enhanced MRI in ovarian cancer: Initial experience at 3 tesla in primary and metastatic disease.

E-pub date: 01 Apr 2010

Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers.

E-pub date: 23 Mar 2010

Apparent diffusion coefficient and vascular signal fraction measurements with magnetic resonance imaging: feasibility in metastatic ovarian cancer at 3 Tesla: technical development.

E-pub date: 01 Feb 2010

Correlations between in vivo (1)H MRS and ex vivo (1)H HRMAS metabolite measurements in adult human gliomas.

E-pub date: 01 Feb 2010

Tri-partite complex for axonal transport drug delivery achieves pharmacological effect.

E-pub date: 20 Jan 2010

Pattern recognition of MRSI data shows regions of glioma growth that agree with DTI markers of brain tumor infiltration.

E-pub date: 31 Dec 2009

Metabolic characterization of primary and metastatic ovarian cancer by 1H-MRS in vivo at 3T.

E-pub date: 31 Oct 2009

Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques.

E-pub date: 31 Aug 2009

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.

E-pub date: 12 Jun 2009

In vivo 31P magnetic resonance spectroscopy using a needle microcoil.

E-pub date: 31 May 2009

Taurine: a potential marker of apoptosis in gliomas.

E-pub date: 10 Mar 2009

Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts.

E-pub date: 01 Feb 2009

Longitudinal in vivo susceptibility contrast MRI measurements of LS174T colorectal liver metastasis in nude mice.

E-pub date: 31 Dec 2008

Effect of Gd-DTPA-BMA on choline signals of HT29 tumors detected by in vivo 1H MRS.

E-pub date: 01 Nov 2008

Toward accurate quantification of metabolites, lipids, and macromolecules in HRMAS spectra of human brain tumor biopsies using LCModel.

E-pub date: 01 Nov 2008

An assessment of the effects of sample ischaemia and spinning time on the metabolic profile of brain tumour biopsy specimens as determined by high-resolution magic angle spinning (1)H NMR.

E-pub date: 01 Nov 2008

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.

E-pub date: 01 Sep 2008

An investigation of human brain tumour lipids by high-resolution magic angle spinning 1H MRS and histological analysis.

E-pub date: 31 Aug 2008

Vessel size index magnetic resonance imaging to monitor the effect of antivascular treatment in a rodent tumor model.

E-pub date: 01 Aug 2008

Automated quality control protocol for MR spectra of brain tumors.

E-pub date: 01 Jun 2008

Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice.

E-pub date: 09 May 2008

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts.

E-pub date: 01 Apr 2008

Combined metabolomic and proteomic analysis of human atrial fibrillation.

E-pub date: 05 Feb 2008

Apparent T(2) relaxation times of lipid and macromolecules: a study of high-grade tumor spectra.

E-pub date: 31 Jan 2008

Linear discriminant analysis of brain tumour (1)H MR spectra: a comparison of classification using whole spectra versus metabolite quantification.

E-pub date: 31 Dec 2007

Susceptibility contrast magnetic resonance imaging determination of fractional tumor blood volume: a noninvasive imaging biomarker of response to the vascular disrupting agent ZD6126.

E-pub date: 01 Nov 2007

Rat tumor response to the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid as measured by dynamic contrast-enhanced magnetic resonance imaging, plasma 5-hydroxyindoleacetic acid levels, and tumor necrosis.

E-pub date: 01 Mar 2006

Acute tumor response to ZD6126 assessed by intrinsic susceptibility magnetic resonance imaging.

E-pub date: 01 May 2005

Single dose of the antivascular agent, ZD6126 (N-acetylcolchinol-O-phosphate), reduces perfusion for at least 96 hours in the GH3 prolactinoma rat tumor model.

E-pub date: 01 Mar 2004

Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models.

E-pub date: 31 Oct 2003

Increased tumour extracellular pH induced by Bafilomycin A1 inhibits tumour growth and mitosis in vivo and alters 5-fluorouracil pharmacokinetics.

E-pub date: 01 Mar 2003

Understanding the tumor metabolic phenotype in the genomic era.

E-pub date: 01 Feb 2003

Issues in flow and oxygenation dependent contrast (FLOOD) imaging of tumours.

E-pub date: 01 Nov 2001

In-vivo intracellular pH at rest and during exercise in patients with essential hypertension.

E-pub date: 01 Sep 2001

In vivo hyperpolarized 129Xe NMR spectroscopy in tumors.

E-pub date: 01 Sep 2001

Issues of normal tissue toxicity in patient and animal studies–effect of carbogen breathing in rats after 5-fluorouracil treatment.

E-pub date: 01 Aug 2001

Measurement of the extracellular pH of solid tumours in mice by magnetic resonance spectroscopy: a comparison of exogenous (19)F and (31)P probes.

E-pub date: 01 Dec 1999

Continuing ischemic damage after acute middle cerebral artery infarction in humans demonstrated by short-echo proton spectroscopy.

E-pub date: 01 Jun 1995

Pharmacokinetic studies with the antifolate C2-desamino-C2-methyl-N10-propargyl-2′-trifluoromethyl-5,8-dideazafolic acid (CB3988) in mice and rats using in vivo 19F-NMR spectroscopy.

E-pub date: 01 Nov 1990

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