Senior Group Leader

Research Group Home Page: 
Carroll Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

EN1 is a transcriptional dependency in triple-negative breast cancer associated with brain metastasis.

E-pub date: 31 May 2019


Progesterone Receptor Attenuates STAT1-Mediated IFN Signaling in Breast Cancer.

E-pub date: 31 Mar 2019


Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling.

E-pub date: 28 Feb 2019


Identification of ChIP-seq and RIME grade antibodies for Estrogen Receptor alpha.

E-pub date: 01 Jan 2019


A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates.

E-pub date: 31 Dec 2018


Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates.

E-pub date: 31 Dec 2018


Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation.

E-pub date: 31 Oct 2018


ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis.

E-pub date: 30 Sep 2018


A patient-derived explant (PDE) model of hormone-dependent cancer.

E-pub date: 01 Sep 2018


A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer.

E-pub date: 31 Aug 2018


Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer.

E-pub date: 31 Aug 2018


A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes.

E-pub date: 13 Jun 2018


TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers.

E-pub date: 12 Jun 2018


Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer.

E-pub date: 31 May 2018


Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer.

E-pub date: 01 Apr 2018


Identification of potential therapeutic targets in prostate cancer through a cross-species approach.

E-pub date: 31 Mar 2018


Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing.

E-pub date: 01 Jan 2018


Association analysis identifies 65 new breast cancer risk loci.

E-pub date: 31 Oct 2017


Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance.

E-pub date: 31 Oct 2017


Correction: SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development doi: 10.1242/dev.146241.

E-pub date: 30 Sep 2017


RATA: A method for high-throughput identification of RNA bound transcription factors.

E-pub date: 01 Aug 2017


Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer.

E-pub date: 01 Jul 2017


SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development.

E-pub date: 30 Jun 2017


The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions.

E-pub date: 01 Jun 2017


Embryonic transcription factor SOX9 drives breast cancer endocrine resistance.

E-pub date: 30 May 2017


ERRα induces H3K9 demethylation by LSD1 to promote cell invasion.

E-pub date: 11 Apr 2017


Cell cycle-coupled expansion of AR activity promotes cancer progression.

E-pub date: 23 Mar 2017


Corrigendum to “Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity” [Mol. Cell Endocrinol. 440 (2016) 138-150].

E-pub date: 05 Mar 2017


Deciphering the divergent roles of progestogens in breast cancer.

E-pub date: 31 Jan 2017


Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.

E-pub date: 31 Jan 2017


Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity.

E-pub date: 15 Jan 2017


FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

E-pub date: 06 Dec 2016


Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.

E-pub date: 01 Oct 2016


Chromatin Immunoprecipitation-Sequencing (ChIP-seq) for Mapping of Estrogen Receptor-Chromatin Interactions in Breast Cancer.

E-pub date: 31 Aug 2016


An Examination of the Association between FOXA1 Staining Level and Biochemical Recurrence following Salvage Radiation Therapy for Recurrent Prostate Cancer.

E-pub date: 01 Aug 2016


Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer.

E-pub date: 01 Jul 2016


Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.

E-pub date: 31 May 2016


Rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) for analysis of chromatin complexes.

E-pub date: 01 Feb 2016


Understanding Oestrogen Receptor Function in Breast Cancer and its Interaction with the Progesterone Receptor. New Preclinical Findings and their Clinical Implications.

E-pub date: 31 Jan 2016


SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer.

E-pub date: 15 Jan 2016


Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.

E-pub date: 31 Dec 2015


RIME proteomics of estrogen and progesterone receptors in breast cancer.

E-pub date: 01 Dec 2015


APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.

E-pub date: 06 Oct 2015


Corrigendum: Progesterone receptor modulates ERα action in breast cancer.

E-pub date: 01 Oct 2015


Genomic interaction between ER and HMGB2 identifies DDX18 as a novel driver of endocrine resistance in breast cancer cells.

E-pub date: 31 Jul 2015


Progesterone receptor modulates ERα action in breast cancer.

E-pub date: 16 Jul 2015


Transcription factors and chromatin proteins as therapeutic targets in cancer.

E-pub date: 01 Apr 2015


Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype.

E-pub date: 11 Dec 2014


Complex formation and function of estrogen receptor α in transcription requires RIP140.

E-pub date: 01 Oct 2014


Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

E-pub date: 23 Sep 2014


Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer.

E-pub date: 15 Sep 2014


Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer.

E-pub date: 01 Sep 2014


Estrogen receptor beta in prostate cancer: friend or foe?

E-pub date: 31 Aug 2014


The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.

E-pub date: 01 Jun 2014


Steroids, nuclear receptors and breast cancer. Preface.

E-pub date: 25 Jan 2014


Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells.

E-pub date: 01 Dec 2013


Development of an Illumina-based ChIP-exonuclease method provides insight into FoxA1-DNA binding properties.

E-pub date: 30 Nov 2013


Approaches for assessing and discovering protein interactions in cancer.

E-pub date: 01 Nov 2013


Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

E-pub date: 01 Oct 2013


FOXA1 mutations in hormone-dependent cancers.

E-pub date: 31 Aug 2013


Enhancer-derived RNAs: ‘spicing up’ transcription programs.

E-pub date: 31 Jul 2013


Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing.

E-pub date: 11 Jun 2013


A carrier-assisted ChIP-seq method for estrogen receptor-chromatin interactions from breast cancer core needle biopsy samples.

E-pub date: 08 Apr 2013


Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.

E-pub date: 21 Feb 2013


GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility.

E-pub date: 31 Jan 2013


Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells.

E-pub date: 24 Jan 2013


ChIPing away at breast cancer.

E-pub date: 01 Dec 2012


FOXA1 and breast cancer risk.

E-pub date: 01 Nov 2012


Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?

E-pub date: 31 Aug 2012


ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

E-pub date: 31 Aug 2012


FoxA1 is a key mediator of hormonal response in breast and prostate cancer.

E-pub date: 31 Aug 2012


Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1.

E-pub date: 31 Aug 2012


A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response.

E-pub date: 31 May 2012


A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers.

E-pub date: 31 May 2012


Pioneer factors in hormone-dependent cancers.

E-pub date: 04 May 2012


Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells.

E-pub date: 21 Feb 2012


Differential oestrogen receptor binding is associated with clinical outcome in breast cancer.

E-pub date: 04 Jan 2012


A co-ordinated interaction between CTCF and ER in breast cancer cells.

E-pub date: 05 Dec 2011


Pioneer transcription factors: establishing competence for gene expression.

E-pub date: 01 Nov 2011


Oestrogen receptor-co-factor-chromatin specificity in the transcriptional regulation of breast cancer.

E-pub date: 14 Oct 2011


A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression.

E-pub date: 31 Jul 2011


Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1.

E-pub date: 24 Jun 2011


The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells.

E-pub date: 01 Jun 2011


ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.

E-pub date: 31 Mar 2011


Estrogen receptor-positive breast cancer: a multidisciplinary challenge.

E-pub date: 31 Mar 2011


FOXA1 is a key determinant of estrogen receptor function and endocrine response.

E-pub date: 31 Jan 2011


Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance.

E-pub date: 01 Oct 2010


Estrogen receptor action in three dimensions – looping the loop.

E-pub date: 31 Aug 2010


High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.

E-pub date: 14 Jun 2010


A CTCF-independent role for cohesin in tissue-specific transcription.

E-pub date: 31 May 2010


Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications.

E-pub date: 01 May 2010


Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer.

E-pub date: 15 Jan 2010


Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc.

E-pub date: 01 Sep 2009


Estradiol-regulated microRNAs control estradiol response in breast cancer cells.

E-pub date: 31 Aug 2009


Defining and targeting transcription factors in cancer.

E-pub date: 01 Aug 2009


Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.

E-pub date: 23 Jul 2009


FOXA1 is a potential oncogene in anaplastic thyroid carcinoma.

E-pub date: 01 Jun 2009


Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis.

E-pub date: 17 Mar 2009


AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer.

E-pub date: 31 Dec 2008


Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.

E-pub date: 04 Dec 2008


Unique ERalpha cistromes control cell type-specific gene regulation.

E-pub date: 01 Nov 2008


Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity.

E-pub date: 15 Sep 2008


xMAN: extreme MApping of OligoNucleotides.

E-pub date: 01 Aug 2008


Interrogating the genome to understand oestrogen-receptor-mediated transcription.

E-pub date: 01 Apr 2008


Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets.

E-pub date: 31 Mar 2008


FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.

E-pub date: 29 Feb 2008


Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival.

E-pub date: 06 Feb 2008


Three lectures on case-control genetic association analysis.

E-pub date: 01 Jan 2008


Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state.

E-pub date: 01 Sep 2007


A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth.

E-pub date: 31 Jul 2007


Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer.

E-pub date: 01 Jul 2007


Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis.

E-pub date: 06 Mar 2007


Genome-wide analysis of estrogen receptor binding sites.

E-pub date: 01 Nov 2006


A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer.

E-pub date: 31 Aug 2006


Estrogen receptor target gene: an evolving concept.

E-pub date: 31 Aug 2006


Model-based analysis of tiling-arrays for ChIP-chip.

E-pub date: 31 Jul 2006


p63 regulates an adhesion programme and cell survival in epithelial cells.

E-pub date: 01 Jun 2006


Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking.

E-pub date: 31 Aug 2005


Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.

E-pub date: 30 Jun 2005


Estrogen and insulin/IGF-1 cooperatively stimulate cell cycle progression in MCF-7 breast cancer cells through differential regulation of c-Myc and cyclin D1.

E-pub date: 31 Dec 2004


Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells.

E-pub date: 01 Mar 2003


A low abundance pool of nascent p21WAF1/Cip1 is targeted by estrogen to activate cyclin E*Cdk2.

E-pub date: 31 Oct 2001


A pure estrogen antagonist inhibits cyclin E-Cdk2 activity in MCF-7 breast cancer cells and induces accumulation of p130-E2F4 complexes characteristic of quiescence.

E-pub date: 30 Nov 2000


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Research Integrity Conflict of Interest Disclosure: 
Last revised: 
25/09/2018
Company Active Research funding Ownership Royalty payments Commitment to carry out work for a fee Ad hoc reimbursed work Travel Gifts/ other
Azeria Therapeutics Yes No Yes No Yes No No No
Genentech Yes Yes No No Yes No No No
AstraZeneca Yes Yes No No Yes No No No
Seragon No Yes No No Yes No No No
Active Motif Yes No No Yes No No No Yes
AstraZeneca No No No No No No No Yes
Nature publishing group Yes No No No Yes No No No
AACR journals Yes No No No Yes No No No
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