Senior Group Leader

Research Group Home Page: 
Carroll Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes.

E-pub date: 13 Jun 2018


TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers.

E-pub date: 12 Jun 2018


Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer.

E-pub date: 31 May 2018


Identification of potential therapeutic targets in prostate cancer through a cross-species approach.

E-pub date: 31 Mar 2018


Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing.

E-pub date: 01 Jan 2018


RATA: A method for high-throughput identification of RNA bound transcription factors.

E-pub date: 01 Aug 2017


Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer.

E-pub date: 01 Jul 2017


The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions.

E-pub date: 01 Jun 2017


Embryonic transcription factor SOX9 drives breast cancer endocrine resistance.

E-pub date: 30 May 2017


ERRα induces H3K9 demethylation by LSD1 to promote cell invasion.

E-pub date: 11 Apr 2017


Cell cycle-coupled expansion of AR activity promotes cancer progression.

E-pub date: 23 Mar 2017


Corrigendum to “Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity” [Mol. Cell Endocrinol. 440 (2016) 138-150].

E-pub date: 05 Mar 2017


Deciphering the divergent roles of progestogens in breast cancer.

E-pub date: 31 Jan 2017


Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.

E-pub date: 31 Jan 2017


Comprehensive assessment of estrogen receptor beta antibodies in cancer cell line models and tissue reveals critical limitations in reagent specificity.

E-pub date: 15 Jan 2017


FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.

E-pub date: 06 Dec 2016


Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.

E-pub date: 01 Oct 2016


Chromatin Immunoprecipitation-Sequencing (ChIP-seq) for Mapping of Estrogen Receptor-Chromatin Interactions in Breast Cancer.

E-pub date: 31 Aug 2016


Mechanisms of oestrogen receptor (ER) gene regulation in breast cancer.

E-pub date: 01 Jul 2016


Rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) for analysis of chromatin complexes.

E-pub date: 01 Feb 2016


Understanding Oestrogen Receptor Function in Breast Cancer and its Interaction with the Progesterone Receptor. New Preclinical Findings and their Clinical Implications.

E-pub date: 31 Jan 2016


SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer.

E-pub date: 15 Jan 2016


APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.

E-pub date: 06 Oct 2015


Corrigendum: Progesterone receptor modulates ERα action in breast cancer.

E-pub date: 01 Oct 2015


Genomic interaction between ER and HMGB2 identifies DDX18 as a novel driver of endocrine resistance in breast cancer cells.

E-pub date: 31 Jul 2015


Progesterone receptor modulates ERα action in breast cancer.

E-pub date: 16 Jul 2015


Transcription factors and chromatin proteins as therapeutic targets in cancer.

E-pub date: 01 Apr 2015


Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype.

E-pub date: 11 Dec 2014


Complex formation and function of estrogen receptor α in transcription requires RIP140.

E-pub date: 01 Oct 2014


Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer.

E-pub date: 15 Sep 2014


The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex.

E-pub date: 01 Jun 2014


Steroids, nuclear receptors and breast cancer. Preface.

E-pub date: 25 Jan 2014


Approaches for assessing and discovering protein interactions in cancer.

E-pub date: 01 Nov 2013


FOXA1 mutations in hormone-dependent cancers.

E-pub date: 31 Aug 2013


Enhancer-derived RNAs: ‘spicing up’ transcription programs.

E-pub date: 31 Jul 2013


Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing.

E-pub date: 11 Jun 2013


A carrier-assisted ChIP-seq method for estrogen receptor-chromatin interactions from breast cancer core needle biopsy samples.

E-pub date: 08 Apr 2013


Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.

E-pub date: 21 Feb 2013


GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility.

E-pub date: 31 Jan 2013


FOXA1 and breast cancer risk.

E-pub date: 01 Nov 2012


Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?

E-pub date: 31 Aug 2012


ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

E-pub date: 31 Aug 2012


FoxA1 is a key mediator of hormonal response in breast and prostate cancer.

E-pub date: 31 Aug 2012


Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1.

E-pub date: 31 Aug 2012


A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response.

E-pub date: 31 May 2012


A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers.

E-pub date: 31 May 2012


Pioneer factors in hormone-dependent cancers.

E-pub date: 04 May 2012


Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells.

E-pub date: 21 Feb 2012


Differential oestrogen receptor binding is associated with clinical outcome in breast cancer.

E-pub date: 04 Jan 2012


A co-ordinated interaction between CTCF and ER in breast cancer cells.

E-pub date: 05 Dec 2011


Pioneer transcription factors: establishing competence for gene expression.

E-pub date: 01 Nov 2011


Oestrogen receptor-co-factor-chromatin specificity in the transcriptional regulation of breast cancer.

E-pub date: 14 Oct 2011


Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1.

E-pub date: 24 Jun 2011


The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells.

E-pub date: 01 Jun 2011


ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.

E-pub date: 31 Mar 2011


Estrogen receptor-positive breast cancer: a multidisciplinary challenge.

E-pub date: 31 Mar 2011


FOXA1 is a key determinant of estrogen receptor function and endocrine response.

E-pub date: 31 Jan 2011


Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance.

E-pub date: 01 Oct 2010


Estrogen receptor action in three dimensions – looping the loop.

E-pub date: 31 Aug 2010


High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.

E-pub date: 14 Jun 2010


A CTCF-independent role for cohesin in tissue-specific transcription.

E-pub date: 31 May 2010


Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer.

E-pub date: 15 Jan 2010


Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc.

E-pub date: 01 Sep 2009


Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.

E-pub date: 23 Jul 2009


FOXA1 is a potential oncogene in anaplastic thyroid carcinoma.

E-pub date: 01 Jun 2009


Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis.

E-pub date: 17 Mar 2009


AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer.

E-pub date: 31 Dec 2008


Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.

E-pub date: 04 Dec 2008


Unique ERalpha cistromes control cell type-specific gene regulation.

E-pub date: 01 Nov 2008


Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity.

E-pub date: 15 Sep 2008


Interrogating the genome to understand oestrogen-receptor-mediated transcription.

E-pub date: 01 Apr 2008


Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets.

E-pub date: 31 Mar 2008


Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival.

E-pub date: 06 Feb 2008


Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state.

E-pub date: 01 Sep 2007


Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer.

E-pub date: 01 Jul 2007


Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis.

E-pub date: 06 Mar 2007


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