Senior Group Leader

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Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE

Low perfusion compartments in glioblastoma quantified by advanced magnetic resonance imaging and correlated with patient survival.

E-pub date: 01 May 2019

Decoding the Interdependence of Multiparametric Magnetic Resonance Imaging to Reveal Patient Subgroups Correlated with Survivals.

E-pub date: 28 Feb 2019

Multi-parametric and multi-regional histogram analysis of MRI: modality integration reveals imaging phenotypes of glioblastoma.

E-pub date: 31 Jan 2019

Immuno-phenotypes of Pancreatic Ductal Adenocarcinoma: Meta-analysis of transcriptional subtypes.

E-pub date: 31 Jan 2019

Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors.

E-pub date: 01 Nov 2018

Genome-wide Estrogen Receptor-α activation is sustained, not cyclical.

E-pub date: 31 Oct 2018

Neutral tumor evolution?

E-pub date: 30 Sep 2018

Intratumoral Heterogeneity of Glioblastoma Infiltration Revealed by Joint Histogram Analysis of Diffusion Tensor Imaging.

E-pub date: 31 Aug 2018

KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.

E-pub date: 31 Jul 2018

Copy number signatures and mutational processes in ovarian carcinoma.

E-pub date: 31 Jul 2018

A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes.

E-pub date: 13 Jun 2018

Parallel factor ChIP provides essential internal control for quantitative differential ChIP-seq.

E-pub date: 17 Apr 2018

Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma.

E-pub date: 31 Aug 2017

Inferring modulators of genetic interactions with epistatic nested effects models.

E-pub date: 01 Apr 2017

All biology is computational biology.

E-pub date: 31 Mar 2017

BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes.

E-pub date: 24 Feb 2017

How Subclonal Modeling Is Changing the Metastatic Paradigm.

E-pub date: 01 Feb 2017

Master Regulators of Oncogenic KRAS Response in Pancreatic Cancer: An Integrative Network Biology Analysis.

E-pub date: 31 Jan 2017

Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry.

E-pub date: 15 Jan 2017

Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study.

E-pub date: 31 Dec 2016

A saltationist theory of cancer evolution.

E-pub date: 28 Sep 2016

OncoNEM: inferring tumor evolution from single-cell sequencing data.

E-pub date: 15 Apr 2016

Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas.

E-pub date: 15 Feb 2016

Regulators of genetic risk of breast cancer identified by integrative network analysis.

E-pub date: 31 Jan 2016

Five selfish reasons to work reproducibly.

E-pub date: 08 Dec 2015

You Are Not Working for Me; I Am Working with You.

E-pub date: 01 Sep 2015

BitPhylogeny: a probabilistic framework for reconstructing intra-tumor phylogenies.

E-pub date: 13 Feb 2015

Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis.

E-pub date: 01 Feb 2015

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

E-pub date: 31 Jan 2015

Cancer evolution: mathematical models and computational inference.

E-pub date: 31 Jan 2015

Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier.

E-pub date: 17 Dec 2014

SANTA: quantifying the functional content of molecular networks.

E-pub date: 01 Sep 2014

GoIFISH: a system for the quantification of single cell heterogeneity from IFISH images.

E-pub date: 26 Aug 2014

Phylogenetic quantification of intra-tumour heterogeneity.

E-pub date: 01 Apr 2014

Dissecting cancer heterogeneity–an unsupervised classification approach.

E-pub date: 01 Nov 2013

Master regulators of FGFR2 signalling and breast cancer risk.

E-pub date: 31 Aug 2013

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.

E-pub date: 31 May 2013

Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling.

E-pub date: 24 Oct 2012

Posterior association networks and functional modules inferred from rich phenotypes of gene perturbations.

E-pub date: 31 Aug 2012

A sparse regulatory network of copy-number driven gene expression reveals putative breast cancer oncogenes.

E-pub date: 31 Jul 2012

Diverse epigenetic strategies interact to control epidermal differentiation.

E-pub date: 24 Jun 2012

RedeR: R/Bioconductor package for representing modular structures, nested networks and multiple levels of hierarchical associations.

E-pub date: 24 Apr 2012

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.

E-pub date: 18 Apr 2012

Patient-specific data fusion defines prognostic cancer subtypes.

E-pub date: 31 Oct 2011

Penalized regression elucidates aberration hotspots mediating subtype-specific transcriptional responses in breast cancer.

E-pub date: 01 Oct 2011

Differential C3NET reveals disease networks of direct physical interactions.

E-pub date: 21 Jul 2011

Deregulation upon DNA damage revealed by joint analysis of context-specific perturbation data.

E-pub date: 21 Jun 2011

HTSanalyzeR: an R/Bioconductor package for integrated network analysis of high-throughput screens.

E-pub date: 15 Mar 2011

Evolutionary distances in the twilight zone–a rational kernel approach.

E-pub date: 31 Dec 2010

Mapping dynamic histone acetylation patterns to gene expression in nanog-depleted murine embryonic stem cells.

E-pub date: 16 Dec 2010

How to understand the cell by breaking it: network analysis of gene perturbation screens.

E-pub date: 26 Feb 2010

Systems-level dynamic analyses of fate change in murine embryonic stem cells.

E-pub date: 19 Nov 2009

Analyzing gene perturbation screens with nested effects models in R and bioconductor.

E-pub date: 01 Nov 2008

Computational diagnostics with gene expression profiles.

E-pub date: 31 Aug 2008

Structure learning in Nested Effects Models.

E-pub date: 31 Aug 2008

Inferring cellular networks–a review.

E-pub date: 27 Sep 2007

Computational identification of cellular networks and pathways.

E-pub date: 31 Jul 2007

Nested effects models for high-dimensional phenotyping screens.

E-pub date: 01 Jul 2007

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Research Integrity Conflict of Interest Disclosure: 
Last revised: 
Company Active Research funding Ownership Royalty payments Commitment to carry out work for a fee Ad hoc reimbursed work Travel Gifts/ other
Definiens No No No Yes No No No Yes
Agilent Yes Yes No No No No No No
Cambridge University Press Yes No No Yes No No No No
Kristkeitz Verlag Yes No No Yes No No No No
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