Clinician scientist

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Brindle Group

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Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer.

E-pub date: 30 Jun 2019

Sodium homeostasis in the tumour microenvironment.

E-pub date: 30 Jun 2019

Molecular imaging of the prostate: Comparing total sodium concentration quantification in prostate cancer and normal tissue using dedicated 13 C and 23 Na endorectal coils.

E-pub date: 30 Apr 2019

Measuring Tissue Sodium Concentration: Cross-Vendor Repeatability and Reproducibility of 23 Na-MRI Across Two Sites.

E-pub date: 28 Feb 2019

Non-invasive assessment of glioma microstructure using VERDICT MRI: correlation with histology.

E-pub date: 28 Feb 2019

Multi-site repeatability and reproducibility of MR fingerprinting of the healthy brain at 1.5 and 3.0 T.

E-pub date: 28 Feb 2019

Evaluation of the sensitivity of R1ρ MRI to pH and macromolecular density.

E-pub date: 31 Jan 2019

Repeatability of diffusion-weighted MRI of the prostate using whole lesion ADC values, skew and histogram analysis.

E-pub date: 01 Jan 2019

Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer.

E-pub date: 01 Jan 2019

Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.

E-pub date: 31 Dec 2018

Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology.

E-pub date: 31 Oct 2018

13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.

E-pub date: 30 Sep 2018

Diagnostic evaluation of magnetization transfer and diffusion kurtosis imaging for prostate cancer detection in a re-biopsy population.

E-pub date: 31 Aug 2018

Quantification of Total and Intracellular Sodium Concentration in Primary Prostate Cancer and Adjacent Normal Prostate Tissue With Magnetic Resonance Imaging.

E-pub date: 31 Aug 2018

Metabolic and Molecular Imaging with Hyperpolarised Tracers.

E-pub date: 31 Jul 2018

Ultra-early response assessment in lymphoma treatment: [18F]FDG PET/MR captures changes in glucose metabolism and cell density within the first 72 hours of treatment.

E-pub date: 01 Jun 2018

Hyperpolarized carbon-13 magnetic resonance spectroscopic imaging: a clinical tool for studying tumour metabolism.

E-pub date: 31 May 2018

Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate.

E-pub date: 31 May 2018

Imaging intralesional heterogeneity of sodium concentration in multiple sclerosis: Initial evidence from 23Na-MRI.

E-pub date: 15 Apr 2018

Unsupervised Segmentation of 5D Hyperpolarized Carbon-13 MRI Data Using a Fuzzy Markov Random Field Model.

E-pub date: 01 Apr 2018

Translating in vivo metabolomic analysis of succinate dehydrogenase deficient tumours into clinical utility.

E-pub date: 28 Feb 2018

Extracellular Lactate: A Novel Measure of T Cell Proliferation.

E-pub date: 01 Feb 2018

The longitudinal effect of ejaculation on seminal vesicle fluid volume and whole-prostate ADC as measured on prostate MRI.

E-pub date: 31 Dec 2017

Hyperpolarized [1,4-13C2]Fumarate Enables Magnetic Resonance-Based Imaging of Myocardial Necrosis.

E-pub date: 08 Dec 2017

A method for mapping and quantifying whole organ diffusion-weighted image distortion in MR imaging of the prostate.

E-pub date: 05 Oct 2017

Clinical significance of prostate 18F-labelled fluorodeoxyglucose uptake on positron emission tomography/computed tomography: A five-year review.

E-pub date: 28 Sep 2017

Comparison of initial and tertiary centre second opinion reads of multiparametric magnetic resonance imaging of the prostate prior to repeat biopsy.

E-pub date: 01 Jun 2017

Imaging biomarker roadmap for cancer studies.

E-pub date: 31 Mar 2017

Robotic assisted laparoscopic radical prostatectomy following transrectal compared to transperineal prostate biopsy: surgical, oncological and functional outcomes.

E-pub date: 01 Feb 2017

The Prostate Health Index adds predictive value to multi-parametric MRI in detecting significant prostate cancers in a repeat biopsy population.

E-pub date: 17 Oct 2016

Evaluating Prostate Cancer Using Fractional Tissue Composition of Radical Prostatectomy Specimens and Pre-Operative Diffusional Kurtosis Magnetic Resonance Imaging.

E-pub date: 31 Aug 2016

Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.

E-pub date: 31 Aug 2016

Targeted transperineal biopsy of the prostate has limited additional benefit over background cores for larger MRI-identified tumors.

E-pub date: 01 Apr 2016

A comparison of quantitative methods for clinical imaging with hyperpolarized (13)C-pyruvate.

E-pub date: 01 Apr 2016

MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model.

E-pub date: 31 Mar 2016

Defining the learning curve for multiparametric magnetic resonance imaging (MRI) of the prostate using MRI-transrectal ultrasonography (TRUS) fusion-guided transperineal prostate biopsies as a validation tool.

E-pub date: 31 Jan 2016

Ratio of Tumor to Normal Prostate Tissue Apparent Diffusion Coefficient as a Method for Quantifying DWI of the Prostate.

E-pub date: 31 Dec 2015

Investigating the ability of multiparametric MRI to exclude significant prostate cancer prior to transperineal biopsy.

E-pub date: 01 Nov 2015

Prospective study evaluating the relative sensitivity of 18F-NaF PET/CT for detecting skeletal metastases from renal cell carcinoma in comparison to multidetector CT and 99mTc-MDP bone scintigraphy, using an adaptive trial design.

E-pub date: 31 Oct 2015

Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors.

E-pub date: 01 Oct 2015

Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography.

E-pub date: 07 Jul 2015

Preoperative 3-T diffusion-weighted MRI for the qualitative and quantitative assessment of extracapsular extension in patients with intermediate- or high-risk prostate cancer.

E-pub date: 01 Sep 2014

Prostate cancer: performance characteristics of combined T₂W and DW-MRI scoring in the setting of template transperineal re-biopsy using MR-TRUS fusion.

E-pub date: 31 Jul 2014

Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

E-pub date: 31 Aug 2012

Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis.

E-pub date: 14 Aug 2012

Comparing the accuracy of initial head CT reporting by radiologists, radiology trainees, neuroradiographers and emergency doctors.

E-pub date: 01 Nov 2011

Imaging pH with hyperpolarized 13C.

E-pub date: 31 Oct 2011

Hyperpolarized 13C MRI and PET: in vivo tumor biochemistry.

E-pub date: 01 Sep 2011

Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy.

E-pub date: 31 Aug 2011

Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo.

E-pub date: 03 Aug 2011

Detection of tumor glutamate metabolism in vivo using (13)C magnetic resonance spectroscopy and hyperpolarized [1-(13)C]glutamate.

E-pub date: 31 Jul 2011

Functional and molecular imaging with MRI: potential applications in paediatric radiology.

E-pub date: 01 Feb 2011

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

E-pub date: 01 Feb 2011

Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.

E-pub date: 31 Dec 2010

Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate.

E-pub date: 26 Oct 2010

MR elastography: Spleen stiffness measurements in healthy volunteers–preliminary experience.

E-pub date: 31 Aug 2010

An introduction to functional and molecular imaging with MRI.

E-pub date: 31 Jul 2010

Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study.

E-pub date: 01 Apr 2010

Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma.

E-pub date: 01 Apr 2010

Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors.

E-pub date: 24 Nov 2009

A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment.

E-pub date: 01 Jun 2009

13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine.

E-pub date: 31 Aug 2008

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.

E-pub date: 12 Jun 2008

Postmortem fetal organ volumetry using magnetic resonance imaging and comparison to organ weights at conventional autopsy.

E-pub date: 01 Feb 2008

Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

E-pub date: 01 Nov 2007

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