Executive Assistant

Research Group Home Page: 

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

FrenchFISH: Poisson Models for Quantifying DNA Copy Number From Fluorescence In Situ Hybridization of Tissue Sections.

E-pub date: 01 Feb 2021


Ultrasound-guided targeted biopsies of CT-based radiomic tumour habitats: technical development and initial experience in metastatic ovarian cancer.

E-pub date: 30 Nov 2020


Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development.

E-pub date: 30 Nov 2020


Three-Dimensional Printed Molds for Image-Guided Surgical Biopsies: An Open Source Computational Platform.

E-pub date: 31 Aug 2020


Integrative radiogenomics for virtual biopsy and treatment monitoring in ovarian cancer.

E-pub date: 31 Jul 2020


Unraveling tumor-immune heterogeneity in advanced ovarian cancer uncovers immunogenic effect of chemotherapy.

E-pub date: 08 Jun 2020


Tissue-specific and interpretable sub-segmentation of whole tumour burden on CT images by unsupervised fuzzy clustering.

E-pub date: 01 May 2020


Allele-specific multi-sample copy number segmentation in ASCAT.

E-pub date: 30 Apr 2020


The evolutionary history of 2,658 cancers.

E-pub date: 01 Feb 2020


Inferring structural variant cancer cell fraction.

E-pub date: 31 Jan 2020


Data generation and network reconstruction strategies for single cell transcriptomic profiles of CRISPR-mediated gene perturbations.

E-pub date: 31 Oct 2019


ZMIZ1 — A novel Estrogen Receptor co-activator that enhances the growth of ER+ breast cancer

E-pub date: 30 Sep 2019


Estimating the predictability of cancer evolution.

E-pub date: 30 Jun 2019


Correction to: VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer.

E-pub date: 31 May 2019


3D-printed moulds of renal tumours for image-guided tissue sampling in the clinical setting

E-pub date: 31 May 2019


Low perfusion compartments in glioblastoma quantified by advanced magnetic resonance imaging and correlated with patient survival.

E-pub date: 01 May 2019


VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer.

E-pub date: 30 Apr 2019


The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer.

E-pub date: 30 Apr 2019


Characterizing tumor invasiveness of glioblastoma using multiparametric magnetic resonance imaging.

E-pub date: 31 Mar 2019


Decoding the Interdependence of Multiparametric Magnetic Resonance Imaging to Reveal Patient Subgroups Correlated with Survivals.

E-pub date: 28 Feb 2019


Multi-parametric and multi-regional histogram analysis of MRI: modality integration reveals imaging phenotypes of glioblastoma.

E-pub date: 31 Jan 2019


Immuno-phenotypes of Pancreatic Ductal Adenocarcinoma: Meta-analysis of transcriptional subtypes.

E-pub date: 31 Jan 2019


Ccube: A fast and robust method for estimating cancer cell fractions

E-pub date: 30 Nov 2018


frenchFISH: Poisson models for quantifying DNA copy-number from fluorescence in situ hybridisation of tissue sections

E-pub date: 30 Nov 2018


Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors.

E-pub date: 01 Nov 2018


Genome-wide Estrogen Receptor-α activation is sustained, not cyclical.

E-pub date: 31 Oct 2018


Neutral tumor evolution?

E-pub date: 30 Sep 2018


Intratumoral Heterogeneity of Glioblastoma Infiltration Revealed by Joint Histogram Analysis of Diffusion Tensor Imaging.

E-pub date: 31 Aug 2018


Refining cellular pathway models using an ensemble of heterogeneous data sources

E-pub date: 31 Aug 2018


KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.

E-pub date: 31 Jul 2018


Copy number signatures and mutational processes in ovarian carcinoma.

E-pub date: 31 Jul 2018


Genome-wide Estrogen Receptor-α activation is sustained, not cyclical

E-pub date: 31 Jul 2018


The evolutionary history of 2,658 cancers

E-pub date: 01 Jul 2018


Pervasive intra-tumour heterogeneity and subclonal selection across cancer types

E-pub date: 01 Jul 2018


11 The heterogeneous genomic and immune landscapes of lethal metastatic breast cancer

E-pub date: 01 Jul 2018


A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes.

E-pub date: 13 Jun 2018


The integrated genomic and immune landscapes of lethal metastatic breast cancer (MBC)

E-pub date: 30 Apr 2018


Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

E-pub date: 30 Apr 2018


Parallel factor ChIP provides essential internal control for quantitative differential ChIP-seq.

E-pub date: 17 Apr 2018


Intra-tumor heterogeneity defines treatment-resistant HER2+ breast tumors

E-pub date: 31 Mar 2018


Network analysis of ChIP-seq data by VULCAN identifies GRHL2 as a key co-regulator of ERa in luminal breast cancer

E-pub date: 31 Jan 2018


The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1

E-pub date: 30 Sep 2017


Immuno-phenotypes of Pancreatic Ductal Adenocarcinoma: Metaanalysis of transcriptional subtypes

E-pub date: 30 Sep 2017


Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma.

E-pub date: 31 Aug 2017


Novel Quantitative ChIP-seq Methods Measure Absolute Fold-Change in ER Binding Upon Fulvestrant Treatment

E-pub date: 31 Jul 2017


Copy-number signatures and mutational processes in ovarian carcinoma

E-pub date: 31 Jul 2017


The evolutionary history of 2,658 cancers

E-pub date: 30 Jun 2017


Allele-specific multi-sample copy number segmentation

E-pub date: 30 Jun 2017


Inferring modulators of genetic interactions with epistatic nested effects models.

E-pub date: 01 Apr 2017


All biology is computational biology.

E-pub date: 31 Mar 2017


BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes.

E-pub date: 24 Feb 2017


How Subclonal Modeling Is Changing the Metastatic Paradigm.

E-pub date: 01 Feb 2017


Master Regulators of Oncogenic KRAS Response in Pancreatic Cancer: An Integrative Network Biology Analysis.

E-pub date: 31 Jan 2017


Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry.

E-pub date: 15 Jan 2017


Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study.

E-pub date: 31 Dec 2016


A phylogenetic latent feature model for clonal deconvolution

E-pub date: 30 Nov 2016


BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes

E-pub date: 30 Nov 2016


A saltationist theory of cancer evolution.

E-pub date: 28 Sep 2016


Quantifying tumor heterogeneity in the microenvironment

E-pub date: 01 Jul 2016


OncoNEM: inferring tumor evolution from single-cell sequencing data.

E-pub date: 15 Apr 2016


Quantifying patterns of tumor evolution

E-pub date: 01 Apr 2016


Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas.

E-pub date: 15 Feb 2016


Regulators of genetic risk of breast cancer identified by integrative network analysis.

E-pub date: 31 Jan 2016


Five selfish reasons to work reproducibly.

E-pub date: 08 Dec 2015


You Are Not Working for Me; I Am Working with You.

E-pub date: 01 Sep 2015


Automated immunohistochemistry-based identification of molecular subtypes in colorectal cancer

E-pub date: 31 Jul 2015


BitPhylogeny: a probabilistic framework for reconstructing intra-tumor phylogenies.

E-pub date: 13 Feb 2015


Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis.

E-pub date: 01 Feb 2015


A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

E-pub date: 31 Jan 2015


Cancer evolution: mathematical models and computational inference.

E-pub date: 31 Jan 2015


Joining the dots: Network analysis of gene perturbation data

E-pub date: 31 Dec 2014


Systems genetics: Linking genotypes and phenotypes

E-pub date: 31 Dec 2014


An introduction to systems genetics

E-pub date: 31 Dec 2014


Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier.

E-pub date: 17 Dec 2014


Gene regulatory network approaches to interpreting breast cancer GWAS results

E-pub date: 30 Nov 2014


SANTA: quantifying the functional content of molecular networks.

E-pub date: 01 Sep 2014


GoIFISH: a system for the quantification of single cell heterogeneity from IFISH images.

E-pub date: 26 Aug 2014


Phylogenetic quantification of intra-tumour heterogeneity.

E-pub date: 01 Apr 2014


Reconstructing evolving signalling networks by hidden Markov nested effects models

E-pub date: 31 Dec 2013


Dissecting cancer heterogeneity–an unsupervised classification approach.

E-pub date: 01 Nov 2013


Master regulators of FGFR2 signalling and breast cancer risk.

E-pub date: 31 Aug 2013


Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.

E-pub date: 31 May 2013


Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling (Science Translational Medicine (2012) 4, (161er6))

E-pub date: 31 Oct 2012


Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling.

E-pub date: 24 Oct 2012


Posterior association networks and functional modules inferred from rich phenotypes of gene perturbations.

E-pub date: 31 Aug 2012


A sparse regulatory network of copy-number driven gene expression reveals putative breast cancer oncogenes.

E-pub date: 31 Jul 2012


Diverse epigenetic strategies interact to control epidermal differentiation.

E-pub date: 24 Jun 2012


RedeR: R/Bioconductor package for representing modular structures, nested networks and multiple levels of hierarchical associations.

E-pub date: 24 Apr 2012


The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.

E-pub date: 18 Apr 2012


Patient-specific data fusion defines prognostic cancer subtypes.

E-pub date: 31 Oct 2011


Penalized regression elucidates aberration hotspots mediating subtype-specific transcriptional responses in breast cancer.

E-pub date: 01 Oct 2011


Differential C3NET reveals disease networks of direct physical interactions.

E-pub date: 21 Jul 2011


Deregulation upon DNA damage revealed by joint analysis of context-specific perturbation data.

E-pub date: 21 Jun 2011


HTSanalyzeR: an R/Bioconductor package for integrated network analysis of high-throughput screens.

E-pub date: 15 Mar 2011


Evolutionary distances in the twilight zone–a rational kernel approach.

E-pub date: 31 Dec 2010


Mapping dynamic histone acetylation patterns to gene expression in nanog-depleted murine embryonic stem cells.

E-pub date: 16 Dec 2010


How to understand the cell by breaking it: network analysis of gene perturbation screens.

E-pub date: 26 Feb 2010


Systems-level dynamic analyses of fate change in murine embryonic stem cells.

E-pub date: 19 Nov 2009


Analyzing gene perturbation screens with nested effects models in R and bioconductor.

E-pub date: 01 Nov 2008


Computational diagnostics with gene expression profiles.

E-pub date: 31 Aug 2008


Structure learning in Nested Effects Models.

E-pub date: 31 Aug 2008


Inferring cellular networks–a review.

E-pub date: 27 Sep 2007


Computational identification of cellular networks and pathways.

E-pub date: 31 Jul 2007


Nested effects models for high-dimensional phenotyping screens.

E-pub date: 01 Jul 2007


Computational Diagnostics

E-pub date: 01 Jan 1970


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