Senior Group Leader

Research Group Home Page: 
Odom Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.

E-pub date: 30 Sep 2018


Integrative detection and analysis of structural variation in cancer genomes.

E-pub date: 31 Aug 2018


CTCF maintains regulatory homeostasis of cancer pathways.

E-pub date: 31 Jul 2018


Mutational landscape of a chemically-induced mouse model of liver cancer.

E-pub date: 26 Jun 2018


Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis.

E-pub date: 01 Jun 2018


Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes.

E-pub date: 01 Apr 2018


Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.

E-pub date: 16 Feb 2018


Charting the transcriptional regulatory changes in mouse liver during fasting.

E-pub date: 31 Jan 2018


Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression.

E-pub date: 31 Jan 2018


The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity.

E-pub date: 10 Nov 2017


Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution.

E-pub date: 23 Oct 2017


Aging increases cell-to-cell transcriptional variability upon immune stimulation.

E-pub date: 31 Mar 2017


Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis.

E-pub date: 18 Nov 2016


Unwinding Limb Development.

E-pub date: 20 Oct 2016


The Evolutionary Fates of a Large Segmental Duplication in Mouse.

E-pub date: 01 Sep 2016


Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved.

E-pub date: 19 Aug 2016


Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data.

E-pub date: 27 Jun 2016


Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States.

E-pub date: 31 May 2016


The mechanisms shaping the single-cell transcriptional landscape.

E-pub date: 01 Apr 2016


Comparative Genomics: One for all.

E-pub date: 11 Feb 2016


Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions.

E-pub date: 02 Feb 2016


When the Snake Lost Its Limbs, What Did the Mouse and Lizard Say?

E-pub date: 12 Oct 2015


Regulatory Divergence of Transcript Isoforms in a Mammalian Model System.

E-pub date: 31 Aug 2015


Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture.

E-pub date: 03 Mar 2015


Decoupling of evolutionary changes in transcription factor binding and gene expression in mammals.

E-pub date: 01 Feb 2015


Enhancer evolution across 20 mammalian species.

E-pub date: 29 Jan 2015


High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA-tRNA interface.

E-pub date: 01 Nov 2014


Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways.

E-pub date: 03 Oct 2014


Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.

E-pub date: 17 Sep 2014


Gibbon genome and the fast karyotype evolution of small apes.

E-pub date: 11 Sep 2014


Evolution of transcription factor binding in metazoans – mechanisms and functional implications.

E-pub date: 01 Apr 2014


Survival strategies for choosing the right postdoc position.

E-pub date: 10 Mar 2014


Co-binding by YY1 identifies the transcriptionally active, highly conserved set of CTCF-bound regions in primate genomes.

E-pub date: 31 Dec 2013


Cohesin’s role as an active chromatin domain anchorage revealed.

E-pub date: 11 Dec 2013


AHT-ChIP-seq: a completely automated robotic protocol for high-throughput chromatin immunoprecipitation.

E-pub date: 07 Nov 2013


Global gene expression profiling reveals SPINK1 as a potential hepatocellular carcinoma marker.

E-pub date: 31 Aug 2013


Cooperativity and rapid evolution of cobound transcription factors in closely related mammals.

E-pub date: 01 Aug 2013


NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs.

E-pub date: 25 Jul 2013


How to evaluate a graduate studentship, or choosing the right doctoral advisor.

E-pub date: 29 Apr 2013


CTCF and cohesin: linking gene regulatory elements with their targets.

E-pub date: 14 Mar 2013


A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden.

E-pub date: 07 Mar 2013


Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates.

E-pub date: 26 Feb 2013


Latent regulatory potential of human-specific repetitive elements.

E-pub date: 24 Jan 2013


Extensive compensatory cis-trans regulation in the evolution of mouse gene expression.

E-pub date: 31 Dec 2012


The evolutionary landscape of alternative splicing in vertebrate species.

E-pub date: 21 Dec 2012


Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.

E-pub date: 01 Nov 2012


Replication-timing boundaries facilitate cell-type and species-specific regulation of a rearranged human chromosome in mouse.

E-pub date: 01 Oct 2012


Rapid turnover of long noncoding RNAs and the evolution of gene expression.

E-pub date: 31 Aug 2012


Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation.

E-pub date: 27 Jul 2012


Insights into hominid evolution from the gorilla genome sequence.

E-pub date: 07 Mar 2012


Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells.

E-pub date: 21 Feb 2012


Generalizing complexity: a fruitful partnership of functional genomics and systems biology.

E-pub date: 20 Feb 2012


A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation.

E-pub date: 31 Jan 2012


Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages.

E-pub date: 20 Jan 2012


The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.

E-pub date: 20 Nov 2011


Identification of Transcription Factor-DNA Interactions In Vivo.

E-pub date: 31 Aug 2011


Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes.

E-pub date: 28 Aug 2011


Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation.

E-pub date: 31 Mar 2011


Nuclear transcription factors in mammalian mitochondria.

E-pub date: 31 Aug 2010


A CTCF-independent role for cohesin in tissue-specific transcription.

E-pub date: 31 May 2010


Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding.

E-pub date: 21 May 2010


Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.

E-pub date: 21 Jan 2010


Evolution of transcriptional control in mammals.

E-pub date: 31 Dec 2009


ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions.

E-pub date: 31 Jul 2009


Species-specific transcription in mice carrying human chromosome 21.

E-pub date: 17 Oct 2008


Genome-scale validation of deep-sequencing libraries.

E-pub date: 31 Aug 2008


Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor.

E-pub date: 24 Oct 2007


Tissue-specific transcriptional regulation has diverged significantly between human and mouse.

E-pub date: 01 Jun 2007


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