Senior Group Leader

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Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE

IL-7-dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response.

E-pub date: 30 Jun 2019

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.

E-pub date: 31 Mar 2019

Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis.

E-pub date: 28 Feb 2019

Crisflash: Open-source software to generate CRISPR guide RNAs against genomes annotated with individual variation.

E-pub date: 31 Dec 2018

Chromosome assembly of large and complex genomes using multiple references.

E-pub date: 01 Nov 2018

Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci.

E-pub date: 30 Sep 2018

Integrative detection and analysis of structural variation in cancer genomes.

E-pub date: 31 Aug 2018

CTCF maintains regulatory homeostasis of cancer pathways.

E-pub date: 31 Jul 2018

Mutational landscape of a chemically-induced mouse model of liver cancer.

E-pub date: 26 Jun 2018

Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis.

E-pub date: 01 Jun 2018

Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes.

E-pub date: 01 Apr 2018

Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species.

E-pub date: 16 Feb 2018

Charting the transcriptional regulatory changes in mouse liver during fasting.

E-pub date: 31 Jan 2018

Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression.

E-pub date: 31 Jan 2018

The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity.

E-pub date: 10 Nov 2017

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution.

E-pub date: 23 Oct 2017

Aging increases cell-to-cell transcriptional variability upon immune stimulation.

E-pub date: 31 Mar 2017

Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis.

E-pub date: 18 Nov 2016

Unwinding Limb Development.

E-pub date: 20 Oct 2016

The Evolutionary Fates of a Large Segmental Duplication in Mouse.

E-pub date: 01 Sep 2016

Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved.

E-pub date: 19 Aug 2016

Mitochondrial heteroplasmy in vertebrates using ChIP-sequencing data.

E-pub date: 27 Jun 2016

Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States.

E-pub date: 31 May 2016

The mechanisms shaping the single-cell transcriptional landscape.

E-pub date: 01 Apr 2016

Comparative Genomics: One for all.

E-pub date: 11 Feb 2016

Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions.

E-pub date: 02 Feb 2016

When the Snake Lost Its Limbs, What Did the Mouse and Lizard Say?

E-pub date: 12 Oct 2015

Regulatory Divergence of Transcript Isoforms in a Mammalian Model System.

E-pub date: 31 Aug 2015

Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture.

E-pub date: 03 Mar 2015

Decoupling of evolutionary changes in transcription factor binding and gene expression in mammals.

E-pub date: 01 Feb 2015

Enhancer evolution across 20 mammalian species.

E-pub date: 29 Jan 2015

High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA-tRNA interface.

E-pub date: 01 Nov 2014

Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways.

E-pub date: 03 Oct 2014

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.

E-pub date: 17 Sep 2014

Gibbon genome and the fast karyotype evolution of small apes.

E-pub date: 11 Sep 2014

Evolution of transcription factor binding in metazoans – mechanisms and functional implications.

E-pub date: 01 Apr 2014

Survival strategies for choosing the right postdoc position.

E-pub date: 10 Mar 2014

Co-binding by YY1 identifies the transcriptionally active, highly conserved set of CTCF-bound regions in primate genomes.

E-pub date: 31 Dec 2013

Cohesin’s role as an active chromatin domain anchorage revealed.

E-pub date: 11 Dec 2013

AHT-ChIP-seq: a completely automated robotic protocol for high-throughput chromatin immunoprecipitation.

E-pub date: 07 Nov 2013

Global gene expression profiling reveals SPINK1 as a potential hepatocellular carcinoma marker.

E-pub date: 31 Aug 2013

Cooperativity and rapid evolution of cobound transcription factors in closely related mammals.

E-pub date: 01 Aug 2013

NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs.

E-pub date: 25 Jul 2013

How to evaluate a graduate studentship, or choosing the right doctoral advisor.

E-pub date: 29 Apr 2013

CTCF and cohesin: linking gene regulatory elements with their targets.

E-pub date: 14 Mar 2013

A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden.

E-pub date: 07 Mar 2013

Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates.

E-pub date: 26 Feb 2013

Latent regulatory potential of human-specific repetitive elements.

E-pub date: 24 Jan 2013

Extensive compensatory cis-trans regulation in the evolution of mouse gene expression.

E-pub date: 31 Dec 2012

The evolutionary landscape of alternative splicing in vertebrate species.

E-pub date: 21 Dec 2012

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.

E-pub date: 01 Nov 2012

Replication-timing boundaries facilitate cell-type and species-specific regulation of a rearranged human chromosome in mouse.

E-pub date: 01 Oct 2012

Rapid turnover of long noncoding RNAs and the evolution of gene expression.

E-pub date: 31 Aug 2012

Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation.

E-pub date: 27 Jul 2012

Insights into hominid evolution from the gorilla genome sequence.

E-pub date: 07 Mar 2012

Transducin-like enhancer protein 1 mediates estrogen receptor binding and transcriptional activity in breast cancer cells.

E-pub date: 21 Feb 2012

Generalizing complexity: a fruitful partnership of functional genomics and systems biology.

E-pub date: 20 Feb 2012

A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation.

E-pub date: 31 Jan 2012

Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages.

E-pub date: 20 Jan 2012

The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.

E-pub date: 20 Nov 2011

Identification of Transcription Factor-DNA Interactions In Vivo.

E-pub date: 31 Aug 2011

Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes.

E-pub date: 28 Aug 2011

Global impact of RNA polymerase II elongation inhibition on alternative splicing regulation.

E-pub date: 31 Mar 2011

Nuclear transcription factors in mammalian mitochondria.

E-pub date: 31 Aug 2010

A CTCF-independent role for cohesin in tissue-specific transcription.

E-pub date: 31 May 2010

Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding.

E-pub date: 21 May 2010

Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.

E-pub date: 21 Jan 2010

Evolution of transcriptional control in mammals.

E-pub date: 31 Dec 2009

ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions.

E-pub date: 31 Jul 2009

Species-specific transcription in mice carrying human chromosome 21.

E-pub date: 17 Oct 2008

Genome-scale validation of deep-sequencing libraries.

E-pub date: 31 Aug 2008

Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor.

E-pub date: 24 Oct 2007

Tissue-specific transcriptional regulation has diverged significantly between human and mouse.

E-pub date: 01 Jun 2007

Long-range oxidative damage in DNA/RNA duplexes.

E-pub date: 30 Jun 2001

Charge transport through DNA four-way junctions.

E-pub date: 30 Apr 2001

Robust charge transport in DNA double crossover assemblies.

E-pub date: 01 Jul 2000

Recognition and reaction of metallointercalators with DNA.

E-pub date: 31 Aug 1999

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