Senior Group Leader

Research Group Home Page: 
Winton Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Quantifying Microsatellite Mutation Rates from Intestinal Stem Cell Dynamics in Msh2-deficient Murine Epithelium.

E-pub date: 30 Apr 2019


Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer.

E-pub date: 01 Oct 2018


Itraconazole targets cell cycle heterogeneity in colorectal cancer.

E-pub date: 02 Jul 2018


Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration.

E-pub date: 30 Jun 2018


Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.

E-pub date: 01 Jun 2018


Metaplastic Cdx2-depleted cells can be very disruptive neighbors.

E-pub date: 05 Mar 2018


Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells.

E-pub date: 01 Jun 2017


Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation.

E-pub date: 08 May 2017


Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny.

E-pub date: 25 Oct 2016


Turning off the BCL-2 switch to prevent intestinal tumorigenesis.

E-pub date: 17 May 2016


Detection of colorectal dysplasia using fluorescently labelled lectins.

E-pub date: 13 Apr 2016


Bcl-2 is a critical mediator of intestinal transformation.

E-pub date: 09 Mar 2016


Isolation of Human Colon Stem Cells Using Surface Expression of PTK7.

E-pub date: 08 Dec 2015


Lineage selection and plasticity in the intestinal crypt.

E-pub date: 31 Dec 2014


Side population sorting separates subfractions of cycling and non-cycling intestinal stem cells.

E-pub date: 31 Mar 2014


Defining stem cell dynamics in models of intestinal tumor initiation.

E-pub date: 22 Nov 2013


Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas.

E-pub date: 07 Nov 2013


miR-34a sets the “sweet spot” for notch in colorectal cancer stem cells.

E-pub date: 02 May 2013


Intestinal label-retaining cells are secretory precursors expressing Lgr5.

E-pub date: 07 Mar 2013


Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

E-pub date: 30 May 2012


Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.

E-pub date: 04 Mar 2012


Cdx2 determines the fate of postnatal intestinal endoderm.

E-pub date: 01 Feb 2012


Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis.

E-pub date: 06 Nov 2011


Stem cells, quiescence and rectal carcinoma: an unexplored relationship and potential therapeutic target.

E-pub date: 25 Oct 2011


Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system.

E-pub date: 31 Aug 2011


mTOR regulation by JNK: rescuing the starving intestinal cancer cell?

E-pub date: 31 May 2011


β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.

E-pub date: 13 Jan 2011


Intestinal stem cell replacement follows a pattern of neutral drift.

E-pub date: 05 Nov 2010


V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a.

E-pub date: 01 Nov 2010


Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

E-pub date: 17 Aug 2010


Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer.

E-pub date: 15 Aug 2010


Characterization of a heat resistant beta-glucosidase as a new reporter in cells and mice.

E-pub date: 22 Jun 2010


E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.

E-pub date: 17 Dec 2009


Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.

E-pub date: 31 Oct 2009


Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine.

E-pub date: 31 Aug 2009


Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.

E-pub date: 31 Dec 2008


A historical analysis of herpes simplex virus promoter activation in vivo reveals distinct populations of latently infected neurones.

E-pub date: 31 Dec 2008


Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.

E-pub date: 28 Jun 2007


A single type of progenitor cell maintains normal epidermis.

E-pub date: 08 Mar 2007


Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.

E-pub date: 01 May 2004


In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine.

E-pub date: 01 Apr 2000


Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine.

E-pub date: 28 Feb 1999


The mutagenicity of benzo[a]pyrene in mouse small intestine.

E-pub date: 01 Jan 1999


A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel.

E-pub date: 01 Dec 1992


Effect of gamma radiation at high- and low-dose rate on a novel in vivo mutation assay in mouse intestine.

E-pub date: 01 Sep 1989


Polyclonal origin of mouse skin papillomas.

E-pub date: 01 Jul 1989


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Research Integrity Conflict of Interest Disclosure: 
Last revised: 
12/09/2018
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