Associate Scientist

Research Group Home Page: 

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

Activation-induced cytidine deaminase localizes to G-quadruplex motifs at mutation hotspots in lymphoma.

E-pub date: 01 Dec 2020


Landscape of G-quadruplex DNA structural regions in breast cancer.

E-pub date: 31 Jul 2020


Genome-wide DNA methylation signatures are determined by DNMT3A/B sequence preferences.

E-pub date: 31 May 2020


ctDNA monitoring using patient-specific sequencing and integration of variant reads.

E-pub date: 31 May 2020


Detection of ctDNA from Dried Blood Spots after DNA Size Selection.

E-pub date: 31 Mar 2020


The regulation and functions of DNA and RNA G-quadruplexes.

E-pub date: 31 Mar 2020


Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors.

E-pub date: 31 Jan 2020


Detection of ctDNA from dried blood spots after DNA size selection

E-pub date: 31 Aug 2019


High-sensitivity monitoring of ctDNA by patient-specific sequencing panels and integration of variant reads

E-pub date: 31 Aug 2019


Integrated clonal analysis reveals circulating tumor DNA in urine and plasma of glioma patients

E-pub date: 31 Aug 2019


Comprehensive characterisation of cell-free tumour DNA in plasma and urine of patients with renal tumours

E-pub date: 31 Aug 2019


Sensitive detection of ctDNA in low burden and ‘challenging’ cancers

E-pub date: 01 Jul 2019


Improved ctDNA detection in early stage non-small-cell lung cancer

E-pub date: 01 Jul 2019


Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors

E-pub date: 01 Jul 2019


Genetic interactions of G-quadruplexes in humans.

E-pub date: 30 Jun 2019


Addressing the dichotomy between individual and societal approaches to personalised medicine in oncology.

E-pub date: 01 Jun 2019


Measurement of plasma cell-free mitochondrial tumor DNA improves detection of glioblastoma in patient-derived orthotopic xenograft models.

E-pub date: 31 Oct 2018


Enhanced detection of circulating tumor DNA by fragment size analysis.

E-pub date: 31 Oct 2018


Detection of cell-free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients.

E-pub date: 31 Oct 2018


DNA G-quadruplex structures mold the DNA methylome.

E-pub date: 30 Sep 2018


Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts.

E-pub date: 31 Aug 2018


Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer.

E-pub date: 01 Jun 2018


Identification of the extracellular matrix protein Fibulin-2 as a regulator of spinal nerve organization.

E-pub date: 31 May 2018


Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing.

E-pub date: 31 Mar 2018


Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule.

E-pub date: 22 Mar 2018


Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.

E-pub date: 31 Jan 2018


Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis.

E-pub date: 01 Oct 2017


Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer.

E-pub date: 17 Jul 2017


BRAF and NRAS Locus-Specific Variants Have Different Outcomes on Survival to Colorectal Cancer.

E-pub date: 01 Jun 2017


Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer.

E-pub date: 31 May 2017


DSBCapture: in situ capture and sequencing of DNA breaks.

E-pub date: 31 Oct 2016


G-quadruplex structures mark human regulatory chromatin.

E-pub date: 31 Oct 2016


Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.

E-pub date: 30 Jun 2016


Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.

E-pub date: 31 May 2016


Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

E-pub date: 31 Jul 2015


FOXM1 binds directly to non-consensus sequences in the human genome.

E-pub date: 23 Jun 2015


A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.

E-pub date: 30 Apr 2015


Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues.

E-pub date: 31 Aug 2014


Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

E-pub date: 31 Jan 2014


G-quadruplex structures are stable and detectable in human genomic DNA.

E-pub date: 31 Aug 2013


Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

E-pub date: 18 Jul 2013


G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells.

E-pub date: 03 Jul 2013


Quantitative visualization of DNA G-quadruplex structures in human cells.

E-pub date: 31 Mar 2013


An intramolecular G-quadruplex structure is required for binding of telomeric repeat-containing RNA to the telomeric protein TRF2.

E-pub date: 25 Jul 2012


The generation of vertebral segmental patterning in the chick embryo.

E-pub date: 01 Jun 2012


Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.

E-pub date: 27 May 2012


Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial.

E-pub date: 18 Jun 2011


The intrinsic innervation of the lung is derived from neural crest cells as shown by optical projection tomography in Wnt1-Cre;YFP reporter mice.

E-pub date: 31 Dec 2010


Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

E-pub date: 31 Oct 2010


Analysis of the frequency of GNAS codon 201 mutations in advanced colorectal cancer.

E-pub date: 30 Sep 2010


Mutations in FLVCR2 are associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Fowler syndrome).

E-pub date: 12 Mar 2010


Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease.

E-pub date: 05 Feb 2010


Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation.

E-pub date: 22 May 2009


Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code.

E-pub date: 01 Dec 2008


Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.

E-pub date: 06 Nov 2007


Genome-wide computational screen for bloon stem cell enhancers integrates RUNX1 and the BMP signaling pathway into the SCL transcriptional network

E-pub date: 01 Mar 2007


Molecular analysis of axon repulsion by the notochord.

E-pub date: 01 Mar 2003


A critical role for sonic hedgehog signaling in the early expansion of the developing brain

E-pub date: 01 Feb 2002


The role of the notochord in vertebral column formation

E-pub date: 31 Aug 2001


The role of the notochord in vertebral column formation.

E-pub date: 01 Jul 2001


Axon guidance and somites

E-pub date: 01 Feb 1998


Axon guidance to and from choice points.

E-pub date: 01 Feb 1998


Axon guidance and somites.

E-pub date: 01 Nov 1997


Surround repulsion of spinal sensory axons in higher vertebrate embryos.

E-pub date: 01 Jun 1997


Enlightening the path of axons.

E-pub date: 01 Dec 1996


Identification and developmental expression of the Xenopus laevis cystic fibrosis transmembrane conductance regulator gene.

E-pub date: 01 May 1992


Effects of orientation and position on the activity of a herpes simplex virus immediate early gene far-upstream region.

E-pub date: 01 Sep 1984


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