Chair, Surgical Oncology

Research Group Home Page: 

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

DESNT: A Poor Prognosis Category of Human Prostate Cancer.

E-pub date: 06 Mar 2017


Mortality Among Men with Advanced Prostate Cancer Excluded from the ProtecT Trial.

E-pub date: 01 Mar 2017


Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes.

E-pub date: 01 Oct 2016


Incidence of needle-tract seeding following prostate biopsy for suspected cancer: a review of the literature.

E-pub date: 31 May 2015


Standardisation of information submitted to an endpoint committee for cause of death assignment in a cancer screening trial – lessons learnt from CAP (Cluster randomised triAl of PSA testing for Prostate cancer).

E-pub date: 23 Jan 2015


Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype.

E-pub date: 11 Dec 2014


N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 is overexpressed in cancer and promotes a pro-migratory and pro-metastatic phenotype.

E-pub date: 06 Nov 2014


Adherence to dietary and lifestyle recommendations and prostate cancer risk in the prostate testing for cancer and treatment (ProtecT) trial.

E-pub date: 31 Oct 2014


Estrogen receptor beta in prostate cancer: friend or foe?

E-pub date: 31 Aug 2014


Late Imaging with [1-(11)C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET.

E-pub date: 31 Jul 2014


Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.

E-pub date: 31 Jul 2014


Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.

E-pub date: 17 Jun 2014


Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells.

E-pub date: 15 Jun 2014


Design and preliminary recruitment results of the Cluster randomised triAl of PSA testing for Prostate cancer (CAP).

E-pub date: 10 Jun 2014


The ETS family member GABPα modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer.

E-pub date: 01 Jun 2014


HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network.

E-pub date: 31 May 2014


Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491.

E-pub date: 31 May 2014


PROSPECTIV-a pilot trial of a nurse-led psychoeducational intervention delivered in primary care to prostate cancer survivors: study protocol for a randomised controlled trial.

E-pub date: 22 May 2014


Comparative efficacy and safety of treatments for localised prostate cancer: an application of network meta-analysis.

E-pub date: 15 May 2014


Identification of pathologically insignificant prostate cancer is not accurate in unscreened men.

E-pub date: 13 May 2014


The importance of dietary change for men diagnosed with and at risk of prostate cancer: a multi-centre interview study with men, their partners and health professionals.

E-pub date: 03 May 2014


The transcriptional programme of the androgen receptor (AR) in prostate cancer.

E-pub date: 31 Mar 2014


Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection.

E-pub date: 27 Feb 2014


The National Prostate Cancer Audit – introducing a new generation of cancer audit.

E-pub date: 01 Feb 2014


Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging.

E-pub date: 01 Feb 2014


Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer.

E-pub date: 01 Feb 2014


Evaluating the Prostate Cancer Prevention Trial High Grade Prostate Cancer Risk Calculator in 10 international biopsy cohorts: results from the Prostate Biopsy Collaborative Group.

E-pub date: 01 Feb 2014


A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.

E-pub date: 15 Dec 2013


Psychological impact of prostate biopsy: physical symptoms, anxiety, and depression.

E-pub date: 20 Nov 2013


The first national clinical audit of prostate cancer care.

E-pub date: 01 Nov 2013


Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress.

E-pub date: 20 Aug 2013


Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness.

E-pub date: 31 Jul 2013


Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.

E-pub date: 15 Jun 2013


Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis.

E-pub date: 01 Jun 2013


Predictors of the use of orthotopic bladder reconstruction after radical cystectomy for bladder cancer: data from a pilot study of 1756 cases 2004-2011.

E-pub date: 01 Jun 2013


Men with prostate cancer make positive dietary changes following diagnosis and treatment.

E-pub date: 01 Jun 2013


Alcohol consumption and PSA-detected prostate cancer risk–a case-control nested in the ProtecT study.

E-pub date: 01 May 2013


The role of 1.5 Tesla magnetic resonance imaging in staging prostate cancer.

E-pub date: 01 Apr 2013


Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin d and prostate cancer risk.

E-pub date: 01 Apr 2013


Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.

E-pub date: 01 Apr 2013


Targeting the pro-survival side-effects of androgen-deprivation therapy in prostate cancer.

E-pub date: 01 Apr 2013


Associations of circulating 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and vitamin D pathway genes with prostate-specific antigen progression in men with localized prostate cancer undergoing active monitoring.

E-pub date: 31 Mar 2013


Downregulation of androgen receptor transcription by promoter g-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer.

E-pub date: 26 Feb 2013


The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.

E-pub date: 01 Feb 2013


Associations of adiponectin and leptin with stage and grade of PSA-detected prostate cancer: the ProtecT study.

E-pub date: 01 Feb 2013


Method for sampling tissue for research which preserves pathological data in radical prostatectomy.

E-pub date: 31 Jan 2013


Insulin-like growth factors (IGFs) and IGF-binding proteins in active monitoring of localized prostate cancer: a population-based observational study.

E-pub date: 31 Jan 2013


Very low PSA concentrations and deletions of the KLK3 gene.

E-pub date: 31 Jan 2013


A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.

E-pub date: 15 Jan 2013


The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man.

E-pub date: 14 Jan 2013


Androgen deprivation treatment in prostate cancer.

E-pub date: 31 Dec 2012


A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer.

E-pub date: 31 Dec 2012


Associations of circulating retinol, vitamin E, and 1,25-dihydroxyvitamin D with prostate cancer diagnosis, stage, and grade.

E-pub date: 01 Nov 2012


Evaluating genetic risk for prostate cancer among Japanese and Latinos.

E-pub date: 01 Nov 2012


Predictors of attendance for prostate-specific antigen screening tests and prostate biopsy.

E-pub date: 31 Oct 2012


Associations of lifestyle factors and anthropometric measures with repeat PSA levels during active surveillance/monitoring.

E-pub date: 31 Oct 2012


International multicentre study examining selection criteria for active surveillance in men undergoing radical prostatectomy.

E-pub date: 23 Oct 2012


Diagnosis of bladder cancer by immunocytochemical detection of minichromosome maintenance protein-2 in cells retrieved from urine.

E-pub date: 09 Oct 2012


Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade.

E-pub date: 01 Sep 2012


No evidence for infection of UK prostate cancer patients with XMRV, BK virus, Trichomonas vaginalis or human papilloma viruses.

E-pub date: 31 Aug 2012


The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene.

E-pub date: 01 Aug 2012


General application of the National Institute for Health and Clinical Excellence (NICE) guidance for active surveillance for men with prostate cancer is not appropriate in unscreened populations.

E-pub date: 31 Jul 2012


Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis.

E-pub date: 10 Jul 2012


A cross-sectional analysis of the association between diet and insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein (IGFBP)-2, and IGFBP-3 in men in the United Kingdom.

E-pub date: 01 Jun 2012


RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation.

E-pub date: 01 Jun 2012


Detailed analysis of operating time learning curves in robotic prostatectomy by a novice surgeon.

E-pub date: 01 Apr 2012


Predictors of 25-hydroxyvitamin D and its association with risk factors for prostate cancer: evidence from the prostate testing for cancer and treatment study.

E-pub date: 01 Apr 2012


Importance of prostate volume in the European Randomised Study of Screening for Prostate Cancer (ERSPC) risk calculators: results from the prostate biopsy collaborative group.

E-pub date: 01 Apr 2012


Evaluating the PCPT risk calculator in ten international biopsy cohorts: results from the Prostate Biopsy Collaborative Group.

E-pub date: 01 Apr 2012


The association of diagnosis in the private or NHS sector on prostate cancer stage and treatment.

E-pub date: 31 Mar 2012


DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: a feasibility study.

E-pub date: 31 Mar 2012


The role of surgery in high-risk localised prostate cancer.

E-pub date: 31 Mar 2012


Urinary diversion and bladder reconstruction/replacement using intestinal segments for intractable incontinence or following cystectomy.

E-pub date: 15 Feb 2012


Serum insulin-like growth factors and mortality in localised and advanced clinically detected prostate cancer.

E-pub date: 01 Feb 2012


Circulating insulin-like growth factors and IGF-binding proteins in PSA-detected prostate cancer: the large case-control study ProtecT.

E-pub date: 15 Jan 2012


Short term outcomes of prostate biopsy in men tested for cancer by prostate specific antigen: prospective evaluation within ProtecT study.

E-pub date: 31 Dec 2011


The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6.

E-pub date: 31 Dec 2011


Addressing patient treatment preferences at trial recruitment.

E-pub date: 13 Dec 2011


Understanding factors influencing questionnaire response rates to maximise retention in a long term complex intervention trial.

E-pub date: 13 Dec 2011


Seasonal variation in prostate-specific antigen levels: a large cross-sectional study of men in the UK.

E-pub date: 01 Nov 2011


Prostate-specific antigen testing rates remain low in UK general practice: a cross-sectional study in six English cities.

E-pub date: 01 Nov 2011


Infective complications after transrectal ultrasound-guided prostate biopsy following a new protocol for antibiotic prophylaxis aimed at reducing hospital-acquired infections.

E-pub date: 01 Nov 2011


Randomised surgical trials need good surgical outcomes in the control arm.

E-pub date: 31 Oct 2011


Trends in the use of radiotherapy and radical surgery for patients with bladder urothelial cell carcinoma in East Anglia, 1995-2006.

E-pub date: 31 Oct 2011


Exploring treatment preferences facilitated recruitment to randomized controlled trials.

E-pub date: 31 Oct 2011


Genome-wide association study identifies new prostate cancer susceptibility loci.

E-pub date: 01 Oct 2011


Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.

E-pub date: 01 Oct 2011


Suitability of PSA-detected localised prostate cancers for focal therapy: experience from the ProtecT study.

E-pub date: 27 Sep 2011


A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.

E-pub date: 25 Sep 2011


First 500 cases of robotic-assisted laparoscopic radical prostatectomy from a single UK centre: learning curves of two surgeons.

E-pub date: 01 Sep 2011


Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data.

E-pub date: 31 Aug 2011


Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1.

E-pub date: 31 Aug 2011


Differential C3NET reveals disease networks of direct physical interactions.

E-pub date: 21 Jul 2011


Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.

E-pub date: 10 Jul 2011


Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1.

E-pub date: 24 Jun 2011


A Peer Review Intervention for Monitoring and Evaluating sites (PRIME) that improved randomized controlled trial conduct and performance.

E-pub date: 01 Jun 2011


Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript.

E-pub date: 01 Jun 2011


Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer.

E-pub date: 28 May 2011


The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.

E-pub date: 20 May 2011


Polygenic susceptibility to prostate and breast cancer: implications for personalised screening.

E-pub date: 10 May 2011


Validation of a modelling approach for estimating the likely effectiveness of cancer screening using cancer data on prevalence screening and incidence.

E-pub date: 01 Apr 2011


PSA-detected prostate cancer and the potential for dedifferentiation–estimating the proportion capable of progression.

E-pub date: 15 Mar 2011


Associations of aspirin, nonsteroidal anti-inflammatory drug and paracetamol use with PSA-detected prostate cancer: findings from a large, population-based, case-control study (the ProtecT study).

E-pub date: 15 Mar 2011


Association of obesity with prostate cancer: a case-control study within the population-based PSA testing phase of the ProtecT study.

E-pub date: 01 Mar 2011


Engrailed-2 (EN2): a tumor specific urinary biomarker for the early diagnosis of prostate cancer.

E-pub date: 01 Mar 2011


Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.

E-pub date: 01 Feb 2011


Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers.

E-pub date: 01 Feb 2011


Association of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study).

E-pub date: 15 Jan 2011


Genetic correction of PSA values using sequence variants associated with PSA levels.

E-pub date: 15 Dec 2010


RAS pathways in prostate cancer – mediators of hormone resistance?

E-pub date: 01 Dec 2010


Prostate cancer metabolite quantification relative to water in (1)H-MRSI in vivo at 3 Tesla.

E-pub date: 16 Nov 2010


The relation between adiposity throughout the life course and variation in IGFs and IGFBPs: evidence from the ProtecT (Prostate testing for cancer and Treatment) study.

E-pub date: 01 Nov 2010


Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.

E-pub date: 01 Nov 2010


Latest results from the UK trials evaluating prostate cancer screening and treatment: the CAP and ProtecT studies.

E-pub date: 01 Nov 2010


Associations between an obesity related genetic variant (FTO rs9939609) and prostate cancer risk.

E-pub date: 19 Oct 2010


The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine.

E-pub date: 13 Oct 2010


The relationship between prostate-specific antigen and prostate cancer risk: the Prostate Biopsy Collaborative Group.

E-pub date: 01 Sep 2010


Tumor necrosis factor receptor expression and signaling in renal cell carcinoma.

E-pub date: 31 Aug 2010


PSA testing for prostate cancer improves survival–but can we do better?

E-pub date: 31 Aug 2010


Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis.

E-pub date: 01 Jun 2010


Enhanced recovery: from principles to practice in urology.

E-pub date: 31 May 2010


Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies.

E-pub date: 28 May 2010


Thiol isomerases negatively regulate the cellular shedding activity of ADAM17.

E-pub date: 27 May 2010


Population based time trends and socioeconomic variation in use of radiotherapy and radical surgery for prostate cancer in a UK region: continuous survey.

E-pub date: 31 Mar 2010


Impact of prostate cancer testing: an evaluation of the emotional consequences of a negative biopsy result.

E-pub date: 31 Mar 2010


Development of a new method for monitoring prostate-specific antigen changes in men with localised prostate cancer: a comparison of observational cohorts.

E-pub date: 31 Mar 2010


Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.

E-pub date: 13 Mar 2010


The potential value of microseminoprotein-beta as a prostate cancer biomarker and therapeutic target.

E-pub date: 15 Feb 2010


Mutation analysis of the MSMB gene in familial prostate cancer.

E-pub date: 19 Jan 2010


Associations of sexual dysfunction symptoms with PSA-detected localised and advanced prostate cancer: a case-control study nested within the UK population-based ProtecT (Prostate testing for cancer and Treatment) study.

E-pub date: 31 Dec 2009


Population-based prostate-specific antigen testing in the UK leads to a stage migration of prostate cancer.

E-pub date: 31 Dec 2009


Robotic-assisted laparoscopic prostatectomy.

E-pub date: 03 Nov 2009


Genetic variants in the vitamin d receptor are associated with advanced prostate cancer at diagnosis: findings from the prostate testing for cancer and treatment study and a systematic review.

E-pub date: 01 Nov 2009


Psychological distress and prostate specific antigen levels in men with and without prostate cancer.

E-pub date: 01 Nov 2009


Multiple loci on 8q24 associated with prostate cancer susceptibility.

E-pub date: 31 Oct 2009


Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.

E-pub date: 31 Oct 2009


Screening for prostate cancer remains controversial.

E-pub date: 31 Oct 2009


Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression.

E-pub date: 15 Oct 2009


Life course sun exposure and risk of prostate cancer: population-based nested case-control study and meta-analysis.

E-pub date: 15 Sep 2009


Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis.

E-pub date: 01 Sep 2009


Do the risk factors of age, family history of prostate cancer or a higher prostate specific antigen level raise anxiety at prostate biopsy?

E-pub date: 01 Sep 2009


Stage shift in PSA-detected prostate cancers – effect modification by Gleason score.

E-pub date: 31 Aug 2009


PTGS2-899G>C and prostate cancer risk: a population-based nested case-control study (ProtecT) and a systematic review with meta-analysis.

E-pub date: 31 Aug 2009


Current strategies for monitoring men with localised prostate cancer lack a strong evidence base: observational longitudinal study.

E-pub date: 04 Aug 2009


Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors.

E-pub date: 17 Jul 2009


UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer.

E-pub date: 07 Jul 2009


It’s not just what you say, it’s also how you say it: opening the ‘black box’ of informed consent appointments in randomised controlled trials.

E-pub date: 01 Jun 2009


LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals.

E-pub date: 01 May 2009


Mean sojourn time, overdiagnosis, and reduction in advanced stage prostate cancer due to screening with PSA: implications of sojourn time on screening.

E-pub date: 07 Apr 2009


Feasibility and cost of obtaining informed consent for essential review of medical records in large-scale health services research.

E-pub date: 01 Apr 2009


Treatment for PSA screen-detected prostate cancer: what are the options?

E-pub date: 31 Mar 2009


Factors distinguishing general practitioners who more readily participated in a large randomized trial were identified.

E-pub date: 31 Jan 2009


Development of a complex intervention improved randomization and informed consent in a randomized controlled trial.

E-pub date: 31 Jan 2009


Identification of new genetic risk factors for prostate cancer.

E-pub date: 31 Jan 2009


A recurrent truncating germline mutation in the BRIP1/FANCJ gene and susceptibility to prostate cancer.

E-pub date: 27 Jan 2009


Prostate-specific antigen testing and prostate biopsy: are self-reported lower urinary tract symptoms and health-related quality of life associated with the decision to undergo these investigations?

E-pub date: 31 Dec 2008


AURKA overexpression accompanies dysregulation of DNA-damage response genes in invasive urothelial cell carcinoma.

E-pub date: 15 Nov 2008


Associations of lower urinary tract symptoms with prostate-specific antigen levels, and screen-detected localized and advanced prostate cancer: a case-control study nested within the UK population-based ProtecT (Prostate testing for cancer and Treatment) study.

E-pub date: 01 Nov 2008


Can we accurately identify men with low risk prostate cancer?

E-pub date: 31 Oct 2008


Height and prostate cancer risk: a large nested case-control study (ProtecT) and meta-analysis.

E-pub date: 01 Sep 2008


SNPs in the kallikrein gene region associated with prostate cancer risk: true cause or association by design?

E-pub date: 31 Aug 2008


Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium.

E-pub date: 31 Aug 2008


MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3.

E-pub date: 19 Aug 2008


Alterations in beta-catenin expression and localization in prostate cancer.

E-pub date: 01 Aug 2008


Is continent diversion using the Mitrofanoff principle a viable long-term option for adults requiring bladder replacement?

E-pub date: 31 Jul 2008


Multiple loci with different cancer specificities within the 8q24 gene desert.

E-pub date: 02 Jul 2008


Decision-making about PSA testing and prostate biopsies: a qualitative study embedded in a primary care randomised trial.

E-pub date: 01 Jun 2008


Prostate-cancer mortality in the USA and UK in 1975-2004: an ecological study.

E-pub date: 31 May 2008


Pro-neural transcription factors as cancer markers.

E-pub date: 19 May 2008


High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53.

E-pub date: 01 May 2008


Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer.

E-pub date: 01 May 2008


Contribution of a single repeat PSA test to prostate cancer risk assessment: experience from the ProtecT study.

E-pub date: 01 Apr 2008


Structural basis for the nuclear import of the human androgen receptor.

E-pub date: 01 Apr 2008


Multiple newly identified loci associated with prostate cancer susceptibility.

E-pub date: 31 Mar 2008


Secular trends in prostate cancer mortality, incidence and treatment: England and Wales, 1975-2004.

E-pub date: 31 Mar 2008


Stage migration and pilot studies of reduced chemotherapy supported by positron-emission tomography findings suggest new combined strategies for stage 2 nonseminoma germ cell tumour.

E-pub date: 31 Mar 2008


Low risk research using routinely collected identifiable health information without informed consent: encounters with the Patient Information Advisory Group.

E-pub date: 31 Jan 2008


Malignant germ cell tumours in the elderly: a histopathological review of 50 cases in men aged 60 years or over.

E-pub date: 31 Jan 2008


Detection of prostate cancer in unselected young men: prospective cohort nested within a randomised controlled trial.

E-pub date: 01 Dec 2007


Oral ciprofloxacin or trimethoprim reduces bacteriuria after flexible cystoscopy.

E-pub date: 31 Oct 2007


Reducing warm ischaemia time during laparoscopic partial nephrectomy: a prospective comparison of two renal closure techniques.

E-pub date: 31 Oct 2007


New androgen receptor genomic targets show an interaction with the ETS1 transcription factor.

E-pub date: 01 Sep 2007


Labeling and identification of LNCaP cell surface proteins: a pilot study.

E-pub date: 15 Jun 2007


Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer.

E-pub date: 07 May 2007


RASSF1A promoter methylation is frequently detected in both pre-malignant and non-malignant microdissected prostatic epithelial tissues.

E-pub date: 01 May 2007


A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH.

E-pub date: 29 Mar 2007


SIGN: no. 85–management of transitional cell carcinoma of the bladder.

E-pub date: 01 Nov 2006


The bladder does not appear to have a dynamic secreted continuous mucous gel layer.

E-pub date: 01 Jun 2005


Serum insulin-like growth factor-I is positively associated with serum prostate-specific antigen in middle-aged men without evidence of prostate cancer.

E-pub date: 01 Jan 2004


Who can best recruit to randomized trials? Randomized trial comparing surgeons and nurses recruiting patients to a trial of treatments for localized prostate cancer (the ProtecT study).

E-pub date: 01 Jul 2003


Cytologic analysis of ureteral washings is informative in patients with grade 2 upper tract TCC considering endoscopic treatment.

E-pub date: 01 Jun 2003


Perceptions of equipoise are crucial to trial participation: a qualitative study of men in the ProtecT study.

E-pub date: 01 Jun 2003


Recommendations for urological cancers issued by NICE.

E-pub date: 01 Apr 2003


Recent trends in the use of radical prostatectomy in England: the epidemiology of diffusion.

E-pub date: 01 Mar 2003


Quality improvement report: Improving design and conduct of randomised trials by embedding them in qualitative research: ProtecT (prostate testing for cancer and treatment) study. Commentary: presenting unbiased information to patients can be difficult.

E-pub date: 30 Sep 2002


Vitamin B12 malabsorption following bladder reconstruction or diversion with bowel segments.

E-pub date: 01 Jul 2002


Sexual dysfunction in men after treatment for lower urinary tract symptoms: evidence from randomised controlled trial.

E-pub date: 30 Apr 2002


Distribution of lymphocytes of the alpha(E)beta(7) phenotype and E-cadherin in normal human urothelium and bladder carcinomas.

E-pub date: 01 Dec 2001


Combined p21WAF1/CIP1 and p53 overexpression predict improved survival in muscle-invasive bladder cancer treated by radical radiotherapy.

E-pub date: 30 Nov 2001


Screening for prostate cancer in the UK. Seems to be creeping in by the back door.

E-pub date: 30 Sep 2001


Androgen receptor signalling in the prostate.

E-pub date: 01 Dec 2000


Current status of linkage studies in hereditary prostate cancer.

E-pub date: 01 Oct 2000


Insulin-like growth factor II and androgen receptor expression in the prostate.

E-pub date: 01 Oct 2000


Fibroblast growth factor receptor-2 mutation analysis in human prostate cancer.

E-pub date: 01 Oct 2000


Patient information and consent in trials for the treatment of benign prostatic obstruction.

E-pub date: 01 Mar 2000


Statistical problems with ‘optimal’ thresholds in studies of new prognostic factors in urology.

E-pub date: 01 Mar 2000


Tip60 is a nuclear hormone receptor coactivator.

E-pub date: 31 May 1999


Bladder cancer immunogenicity: expression of CD80 and CD86 is insufficient to allow primary CD4+ T cell activation in vitro.

E-pub date: 01 Apr 1999


Replacement of the urinary bladder.

E-pub date: 01 Apr 1999


Transforming growth factor-beta1 up-regulates p15, p21 and p27 and blocks cell cycling in G1 in human prostate epithelium.

E-pub date: 01 Feb 1999


Ryanodine receptors in human bladder smooth muscle.

E-pub date: 01 Jan 1999


Screening for prostate cancer.

E-pub date: 01 Dec 1998


Expression of Bcl-2, Bax, and p53 in high-grade prostatic intraepithelial neoplasia and localized prostate cancer: relationship with apoptosis and proliferation.

E-pub date: 30 Nov 1998


Bone morphogenetic protein 6 in skeletal metastases from prostate cancer and other common human malignancies.

E-pub date: 01 Nov 1998


p53 and p53-regulated genes in bladder cancer.

E-pub date: 01 Nov 1998


Basal cells are progenitors of luminal cells in primary cultures of differentiating human prostatic epithelium.

E-pub date: 31 Oct 1998


Paracrine regulation of talin mRNA expression by androgen in human prostate.

E-pub date: 31 Jul 1998


Neural network analysis of combined conventional and experimental prognostic markers in prostate cancer: a pilot study.

E-pub date: 01 Jul 1998


Alterations of TP53 in microdissected transitional cell carcinoma of the human urinary bladder: high frequency of TP53 accumulation in the absence of detected mutations is associated with poor prognosis.

E-pub date: 01 Jun 1998


The management of men with acute urinary retention. National Prostatectomy Audit Steering Group.

E-pub date: 01 May 1998


Localized prostate cancer: early intervention or expectant therapy?

E-pub date: 01 Dec 1997


Effects of a new 5 alpha reductase inhibitor (epristeride) on human prostate cell cultures.

E-pub date: 31 Aug 1997


Serum free prostate-specific antigen in the diagnosis of prostate cancer.

E-pub date: 31 Aug 1997


Watchful waiting or drug therapy for benign prostatic hyperplasia?

E-pub date: 31 Jul 1997


Ca2+ mobilization in cultured human bladder smooth muscle cells in response to hypotonic stimuli.

E-pub date: 01 Jul 1997


The National Prostatectomy Audit.

E-pub date: 01 Apr 1997


Androgen regulation of ornithine decarboxylase in human prostatic cells identified using differential display.

E-pub date: 31 Mar 1997


The expression of waf-1, p53 and bcl-2 in prostatic adenocarcinoma.

E-pub date: 01 Feb 1997


The accuracy of recording of occupational history in patients with bladder cancer.

E-pub date: 01 Jan 1997


Bladder cancer.

E-pub date: 01 Dec 1996


Benign prostatic stromal cells are regulated by basic fibroblast growth factor and transforming growth factor-beta 1.

E-pub date: 01 Nov 1996


bcl-2 overexpression combined with p53 protein accumulation correlates with hormone-refractory prostate cancer.

E-pub date: 01 Oct 1996


Breast and prostate cancer in the relatives of men with prostate cancer.

E-pub date: 01 Oct 1996


Cell adhesion molecules in bladder cancer: soluble serum E-cadherin correlates with predictors of recurrence.

E-pub date: 31 Aug 1996


Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

E-pub date: 31 Aug 1996


Surface localization of sacral foramina for neuromodulation of bladder function. An anatomical study.

E-pub date: 01 Aug 1996


TENS: a treatment option for bladder dysfunction.

E-pub date: 01 Aug 1996


Ca2+ signalling in cultured smooth muscle cells from human bladder.

E-pub date: 01 Jul 1996


Peptide growth factors in the prostate as mediators of stromal epithelial interaction.

E-pub date: 01 May 1996


Teaching the teachers–a needs assessment of tutors for a new clinical skills course.

E-pub date: 01 May 1996


The role of the nurse practitioner in a urology service.

E-pub date: 01 Apr 1996


High level expression of the multidrug resistance (MDR1) gene in the normal bladder urothelium: a potential involvement in protection against carcinogens?

E-pub date: 01 Mar 1996


Alterations in expression of the multidrug resistance-associated protein (MRP) gene in high-grade transitional cell carcinoma of the bladder.

E-pub date: 01 Mar 1996


Transforming growth factor alpha and epidermal growth factor levels in bladder cancer and their relationship to epidermal growth factor receptor.

E-pub date: 01 Mar 1996


Ambulatory urodynamics.

E-pub date: 01 Mar 1996


The effect of prostatectomy on symptom severity and quality of life.

E-pub date: 01 Feb 1996


C-erbB-2 in bladder cancer: molecular biology, correlation with epidermal growth factor receptors and prognostic value.

E-pub date: 01 Jan 1996


Transrectal ultrasound appearances of schistosomal prostato-seminovesiculitis.

E-pub date: 01 Jan 1996


The feasibility and cost of a large multicentre audit of process and outcome of prostatectomy.

E-pub date: 01 Dec 1995


Anabolic steroid abuse and male infertility.

E-pub date: 01 Dec 1995


P53 and ploidy assessed by flow cytometry in bladder washings.

E-pub date: 01 Nov 1995


Clinical outcome and quality of life following enterocystoplasty for idiopathic detrusor instability and neurogenic bladder dysfunction.

E-pub date: 01 Nov 1995


Ethical issues and molecular biology in urology.

E-pub date: 01 Nov 1995


Nottingham health profile measurement in the assessment of clinical outcome after prostatectomy. Northern Regional Prostate Audit Group.

E-pub date: 01 Oct 1995


Transrectal ultrasound guided needle electromyography of the urethral sphincter in males.

E-pub date: 01 Aug 1995


Outcome of endoscopic bladder transection.

E-pub date: 01 May 1995


Pelvic fibromatosis (desmoid)–treatment with steroids and tamoxifen.

E-pub date: 01 Apr 1995


The National Prostatectomy Audit: the clinical management of patients during hospital admission.

E-pub date: 01 Mar 1995


Expression of retinoblastoma gene product and p53 protein in bladder carcinoma: correlation with Ki67 index.

E-pub date: 01 Feb 1995


c-jun oncogene expression in transitional cell carcinoma of the urinary bladder.

E-pub date: 01 Dec 1994


Androgen and oestrogen responsiveness of stromal cells derived from the human hyperplastic prostate: oestrogen regulation of the androgen receptor.

E-pub date: 01 Nov 1994


Deaths and complications following prostatectomy in 1400 men in the northern region of England. Northern Regional Prostate Audit Group.

E-pub date: 01 Nov 1994


Continent urinary diversion using the Mitrofanoff principle.

E-pub date: 01 Oct 1994


Written consent about sexual function in men undergoing transurethral prostatectomy.

E-pub date: 01 Oct 1994


Adverse reactions to tiaprofenic acid mimicking interstitial cystitis.

E-pub date: 31 Aug 1994


Evaluation and results of treatments for prostatism.

E-pub date: 01 Aug 1994


Abnormalities in p53 and DNA content in transitional cell carcinoma of the bladder.

E-pub date: 01 May 1994


Frequency of H-ras mutations in human bladder cancer detected by direct sequencing.

E-pub date: 01 May 1994


P53 expression, ploidy and progression in pT1 transitional cell carcinoma of the bladder.

E-pub date: 01 May 1994


Increased mdr1 gene transcript levels in high-grade carcinoma of the bladder determined by quantitative PCR-based assay.

E-pub date: 01 Apr 1994


Transurethral prostatectomy.

E-pub date: 01 Apr 1994


Bladder function in healthy volunteers: ambulatory monitoring and conventional urodynamic studies.

E-pub date: 01 Mar 1994


Glutathione-S-transferase pi expression in transitional cell carcinoma of the bladder.

E-pub date: 01 Nov 1993


p53 expression and clinical outcome in prostate cancer.

E-pub date: 01 Nov 1993


Polyorchism.

E-pub date: 01 Oct 1993


Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer.

E-pub date: 31 Jul 1993


Ambulatory monitoring of bladder pressure in low compliance neurogenic bladder dysfunction.

E-pub date: 01 Nov 1992


Screening for bacteriuria in urological patients using reagent strips.

E-pub date: 01 Sep 1992


Electromyographic abnormalities in the urethral and anal sphincters of women with idiopathic retention of urine.

E-pub date: 01 Jul 1992


P53 and Ki-67 immunoreactivity in human prostate cancer and benign hyperplasia.

E-pub date: 01 Jun 1992


A self-administered patient questionnaire in the assessment of symptoms before and after prostatectomy.

E-pub date: 01 Apr 1992


p53, c-erbB-2 and the epidermal growth factor receptor in the benign and malignant prostate.

E-pub date: 01 Feb 1992


c-erbB-2 amplification and identical p53 mutations in concomitant transitional carcinomas of renal pelvis and urinary bladder.

E-pub date: 31 Jan 1992


Bladder augmentation and replacement. Urodynamic and clinical review of 25 patients.

E-pub date: 01 Dec 1991


The outcome of prostatectomy on chronic retention of urine.

E-pub date: 01 Oct 1991


Filling and voiding pressures measured by ambulatory monitoring and conventional studies during natural and artificial bladder filling.

E-pub date: 01 Sep 1991


Ambulatory monitoring and electronic measurement of urinary leakage in the diagnosis of detrusor instability and incontinence.

E-pub date: 31 Aug 1991


Venous bypass and filtration during nephrectomy for renal carcinoma with tumour thrombus in the retrohepatic cava.

E-pub date: 31 Aug 1991


Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder.

E-pub date: 01 Jun 1991


Urodynamic study of ileocystoplasty in the treatment of idiopathic detrusor instability.

E-pub date: 01 Mar 1991


Systemic chemotherapy for urothelial cancer in patients with ureteric obstruction.

E-pub date: 01 Feb 1991


Is voided urine suitable for flow cytometric DNA analysis?

E-pub date: 01 Jan 1991


Irreversible renal failure in men with outflow obstruction: is it a preventable disease?

E-pub date: 01 Dec 1990


The partial purification and characterization of GnRH-like activity from prostatic biopsy specimens and prostatic cancer cell lines.

E-pub date: 30 Nov 1990


Expression of c-erbB-2 protein product in bladder cancer.

E-pub date: 01 Nov 1990


Prostatectomy–an open or closed case.

E-pub date: 01 Nov 1990


Cell cycling in bladder carcinoma determined by monoclonal antibody Ki67.

E-pub date: 01 Sep 1990


Vasoactive intestinal peptide stimulation of human renal adenylate cyclase in vitro.

E-pub date: 01 Apr 1990


The epidermal growth factor receptor and the prognosis of bladder cancer.

E-pub date: 31 Mar 1990


Acquired venous disease of the lower urinary tract.

E-pub date: 01 Feb 1990


Measurement of voiding pressures on ambulatory monitoring: comparison with conventional cystometry.

E-pub date: 01 Feb 1990


Clean intermittent self-catheterisation in 172 adults.

E-pub date: 01 Jan 1990


Renal carcinoma with adjacent retroperitoneal fibrosis.

E-pub date: 01 Dec 1989


Ambulatory monitoring of bladder and detrusor pressure during natural filling.

E-pub date: 01 Sep 1989


Outcome of elective prostatectomy.

E-pub date: 31 Aug 1989


Ambulatory monitoring of bladder pressures in patients with low compliance as a result of neurogenic bladder dysfunction.

E-pub date: 31 Aug 1989


Urodynamic investigation of the ileal conduit: upper tract dilatation and the effects of revision of the conduit.

E-pub date: 01 Jul 1989


Epidermal growth factor receptor in human bladder cancer: a comparison of immunohistochemistry and ligand binding.

E-pub date: 01 Mar 1989


Late renal failure due to prostatic outflow obstruction.

E-pub date: 28 Feb 1989


Long-term monitoring of bladder pressure in chronic retention of urine: the relationship between detrusor activity and upper tract dilatation.

E-pub date: 31 Aug 1988


Reproducibility of measurement of prostatic volume by ultrasound. Comparison of transrectal and transabdominal methods.

E-pub date: 01 Aug 1988


Immunologically measured serum markers and their role in the management of prostate cancer.

E-pub date: 01 Aug 1988


Urethral dilatation compared with cystoscopy alone in the treatment of women with recurrent frequency and dysuria.

E-pub date: 01 Jun 1988


Conservative management of prostate cancer.

E-pub date: 31 Mar 1988


Relationship between detrusor function and residual urine in men undergoing prostatectomy.

E-pub date: 01 Dec 1987


Relationship between voiding pressures, symptoms and urodynamic findings in 253 men undergoing prostatectomy.

E-pub date: 01 Dec 1987


Evaluation of epidermal growth factor receptors in bladder tumours.

E-pub date: 01 Nov 1987


Histochemical study of lectin binding in neoplastic and non-neoplastic urothelium.

E-pub date: 01 Nov 1987


Preservation of the entire anal canal in conservative proctocolectomy for ulcerative colitis: a pilot study comparing end-to-end ileo-anal anastomosis without mucosal resection with mucosal proctectomy and endo-anal anastomosis.

E-pub date: 01 Oct 1987


Effects of catheter size on urodynamic measurements in men undergoing elective prostatectomy.

E-pub date: 01 Jul 1987


Comparison of long-term monitoring and standard cystometry in chronic retention of urine.

E-pub date: 01 Dec 1986


Chronic retention of urine. The relationship between upper tract dilatation and bladder pressure.

E-pub date: 01 Dec 1986


Comparison of dynamic computed tomography, diuresis renography and DTPA parenchymal transit time in the assessment of dilatation of the upper urinary tract.

E-pub date: 01 Oct 1985


The role of the ileal conduit in the development of upper tract dilatation.

E-pub date: 01 Oct 1985


Complications of ileal conduit diversion in adults with cancer followed up for at least five years.

E-pub date: 31 May 1985


Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours.

E-pub date: 31 Jan 1985


Electrically evoked activity in the human external anal sphincter.

E-pub date: 01 Jan 1985


The effect of resection of the distal ileum on gastric emptying, small bowel transit and absorption after proctocolectomy.

E-pub date: 01 Sep 1984


Histological appearances of the nerves of the bladder in patients with denervation of the bladder after excision of the rectum.

E-pub date: 01 Dec 1982


Rectal, bladder and sexual function after mucosal proctectomy with and without a pelvic reservoir for colitis and polyposis.

E-pub date: 01 Oct 1982


The long term effects of proctectomy on bladder function in patients with inflammatory bowel disease.

E-pub date: 01 Jun 1982


The value of preserving the anal sphincter in operations for ulcerative colitis and polyposis: a review of 22 mucosal proctectomies.

E-pub date: 01 Dec 1981


A prospective study of bladder function before and after sphincter-saving resections for low carcinoma of the rectum.

E-pub date: 01 Dec 1981


Show all