Associate scientist

Research Group Home Page: 
Tavaré Group

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE
Publications: 

The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic.

E-pub date: 31 Jan 2019


Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.

E-pub date: 31 Dec 2018


Author Correction: Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.

E-pub date: 31 Dec 2018


Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts.

E-pub date: 01 Dec 2018


Analysis of variance.

E-pub date: 01 Oct 2018


Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.

E-pub date: 31 Aug 2018


Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

E-pub date: 31 May 2018


Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.

E-pub date: 19 Apr 2018


The role of TET-mediated DNA hydroxymethylation in prostate cancer.

E-pub date: 15 Feb 2018


Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.

E-pub date: 22 Jan 2018


Multicentre cohort study to define and validate pathological assessment of response to neoadjuvant therapy in oesophagogastric adenocarcinoma.

E-pub date: 31 Dec 2017


Corrigendum: A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy.

E-pub date: 31 Oct 2017


Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data.

E-pub date: 01 Sep 2017


Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer.

E-pub date: 29 Aug 2017


New Model for Estimating Glomerular Filtration Rate in Patients With Cancer.

E-pub date: 20 Aug 2017


Genomic Evolution of Breast Cancer Metastasis and Relapse.

E-pub date: 14 Aug 2017


A comparative analysis of whole genome sequencing of esophageal adenocarcinoma pre- and post-chemotherapy.

E-pub date: 01 Jun 2017


Mining Human Prostate Cancer Datasets: The “camcAPP” Shiny App.

E-pub date: 31 Mar 2017


Corrigendum to “Integration of Copy Number and Transcriptomics Provides Risk Stratification in Prostate Cancer: A Discovery and Validation Cohort Study” [EBioMedicine 2 (9) (2015) 1133-1144].

E-pub date: 31 Mar 2017


DESNT: A Poor Prognosis Category of Human Prostate Cancer.

E-pub date: 06 Mar 2017


The importance of DNA methylation in prostate cancer development.

E-pub date: 01 Feb 2017


Corrigendum: Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.

E-pub date: 31 Jan 2017


Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance.

E-pub date: 31 Oct 2016


Whole blood mRNA in prostate cancer reveals a four-gene androgen regulated panel.

E-pub date: 31 Oct 2016


Mutational signatures of ionizing radiation in second malignancies.

E-pub date: 12 Sep 2016


Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.

E-pub date: 07 Sep 2016


The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer.

E-pub date: 31 Aug 2016


Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.

E-pub date: 31 Aug 2016


Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.

E-pub date: 31 May 2016


A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

E-pub date: 09 Dec 2015


Whole-genome sequencing provides new insights into the clonal architecture of Barrett’s esophagus and esophageal adenocarcinoma.

E-pub date: 01 Sep 2015


Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study.

E-pub date: 01 Sep 2015


Crambled: A Shiny application to enable intuitive resolution of conflicting cellularity estimates.

E-pub date: 31 Aug 2015


Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer.

E-pub date: 28 Aug 2015


Mobile element insertions are frequent in oesophageal adenocarcinomas and can mislead paired-end sequencing analysis.

E-pub date: 10 Jul 2015


Corrigendum: analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

E-pub date: 01 Jun 2015


Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

E-pub date: 01 Jun 2015


multiSNV: a probabilistic approach for improving detection of somatic point mutations from multiple related tumour samples.

E-pub date: 19 May 2015


The evolutionary history of lethal metastatic prostate cancer.

E-pub date: 16 Apr 2015


HES5 silencing is an early and recurrent change in prostate tumourigenesis.

E-pub date: 01 Apr 2015


Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

E-pub date: 01 Apr 2015


5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer.

E-pub date: 01 Apr 2015


Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53.

E-pub date: 31 Mar 2015


A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

E-pub date: 31 Jan 2015


Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.

E-pub date: 01 Oct 2014


Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.

E-pub date: 31 Aug 2014


Quantifying the impact of inter-site heterogeneity on the distribution of ChIP-seq data.

E-pub date: 31 Aug 2014


Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

E-pub date: 01 Aug 2014


PTU-153 The Timing Of Oncogenic Events In The Evolution Of The Oesophageal Adenocarcinoma Genome And Implications For Clinical Diagnostics.

E-pub date: 01 Jun 2014


Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress.

E-pub date: 20 Aug 2013


Calling sample mix-ups in cancer population studies.

E-pub date: 31 Aug 2012


The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma.

E-pub date: 31 Aug 2012


The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.

E-pub date: 18 Apr 2012


BeadArray expression analysis using bioconductor.

E-pub date: 31 Dec 2011


The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.

E-pub date: 20 May 2011


ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.

E-pub date: 31 Mar 2011


BayesPeak–an R package for analysing ChIP-seq data.

E-pub date: 01 Mar 2011


The cost of reducing starting RNA quantity for Illumina BeadArrays: a bead-level dilution experiment.

E-pub date: 06 Oct 2010


The importance of platform annotation in interpreting microarray data.

E-pub date: 31 Aug 2010


Does the use of a handheld fan improve chronic dyspnea? A randomized, controlled, crossover trial.

E-pub date: 31 May 2010


Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary.

E-pub date: 31 May 2010


Identification and correction of previously unreported spatial phenomena using raw Illumina BeadArray data.

E-pub date: 27 Apr 2010


A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data.

E-pub date: 31 Jan 2010


The pitfalls of platform comparison: DNA copy number array technologies assessed.

E-pub date: 08 Dec 2009


Considerations for the processing and analysis of GoldenGate-based two-colour Illumina platforms.

E-pub date: 31 Oct 2009


BayesPeak: Bayesian analysis of ChIP-seq data.

E-pub date: 21 Sep 2009


Symptom classification in irritable bowel syndrome as a guide to treatment.

E-pub date: 31 Aug 2009


BASH: a tool for managing BeadArray spatial artefacts.

E-pub date: 15 Dec 2008


Assessing agreement between multiple raters with missing rating information, applied to breast cancer tumour grading.

E-pub date: 13 Aug 2008


Hidden copy number variation in the HapMap population.

E-pub date: 22 Jul 2008


Spike-in validation of an Illumina-specific variance-stabilizing transformation.

E-pub date: 04 Jun 2008


Suprarenal endograft fixation and medium-term renal function: systematic review and meta-analysis.

E-pub date: 01 Jun 2008


Serum albumin level as a predictor of outcome in traumatic brain injury: potential for treatment.

E-pub date: 01 Apr 2008


Statistical issues in the analysis of Illumina data.

E-pub date: 06 Feb 2008


High grade glioma: imaging combined with pathological grade defines management and predicts prognosis.

E-pub date: 31 Dec 2007


Early radiotherapy dose response and lack of hypersensitivity effect in normal brain tissue: a sequential dynamic susceptibility imaging study of cerebral perfusion.

E-pub date: 31 Oct 2007


New androgen receptor genomic targets show an interaction with the ETS1 transcription factor.

E-pub date: 01 Sep 2007


Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization.

E-pub date: 31 Aug 2007


Numbers of copy-number variations and false-negative rates will be underestimated if we do not account for the dependence between repeated experiments.

E-pub date: 31 Aug 2007


Grade III Gliomas with Imaging Appearances of Glioblastoma should be Managed as Glioblastoma.

E-pub date: 01 Apr 2007


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