Light Microscopy Core Facility Manager

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Andreas Bruckbauer joint the CRI in 2022 from Imperial College London, where he managed the FILM Microscopy Facility. Prior to this he was Microscopist Developer with Facundo Batista at the Francis Crick Institute / CRUK London Research Institute.  Andreas completed his postdoctoral training in the laboratory of Professor David Klenerman in the Chemistry Department of the University  of Cambridge (UK) after graduating in Physics and receiving his PhD from the Heinrich-Heine University of Düsseldorf.

He has successfully implemented the super-resolution microscopy techniques Direct Stochastic Reconstruction Microscopy (dSTORM) and Structured Illumination Microscopy (SIM) for research in Immunology. This allowed  the publication of the first super-resolution images of endogenous B cell receptors, showing that these receptors are pre-clustered before B-cell activation. He improved the depth penetration for two-photon microscopy in lymph nodes utilizing this technique for imaging of iNKT cells. His research at Cambridge University was focused on implementing Single Molecule Tracking in Total Internal Fluorescence Microscopy (TIRFM)  in combination with the deposition of biomolecules from a nanopipette using Scanning Ion-conductance Microscopy (SICM).

 

Work address: 
Cancer Research UK Cambridge Institute University of Cambridge Li Ka Shing Centre Robinson Way Cambridge CB2 0RE