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Cancer Research UK Cambridge Institute

Research Associate

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My primary research interest is to perform clinical relevant research which will enable translation of basic research findings into the clinical environment. I have a broad research background including the use of genomics to understand cancer predisposition, utilisation of patient derived xenografts (PDX) to understanding the cellular basis of cancer heterogeneity and investigate the tumour forming potential of phenotypically distinct cell populations and potential genetic relationships between these different cell populations. Therefore, joining the Brenton laboratory will allow me to combine my genomic and cellular backgrounds, while applying my research training to a clinically impactful project to investigate the genetic heterogeneity of phenotypically distinct high grade serous ovarian cancer (HGSOC) cell populations.

Both genetic and phenotypic intra-tumoural heterogeneity has been observed in HGSOC tumours. Where it is hypothesised that these different HGSOC cell subpopulations are present at diagnosis, and contribute to differential HGSOC therapy response. However, characterisation of these subpopulations is difficult. Thus, using preclinical HGSOC PDX models I aim to define and understand the different cell subpopulations and their interactions. This will be complemented by genetic characterisation of the subpopulations and provide insight into evolutionary pressures that explain therapy resistance in HGSOC patients.

Work address: 

Cancer Research UK Cambridge Institute
University of Cambridge
Li Ka Shing Centre
Robinson Way
Cambridge CB2 0RE

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