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Cancer Research UK Cambridge Institute

Postdoctoral scientist

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My research interests center on gene regulation in mammals, and its underlying mechanisms in normal physiology and disease. My current work focuses on the application of novel genomic tools to study these processes at the whole-genome level. This research aims to improve our understanding of the molecular genetics underpinning gene regulation in mammals, and how perturbations in these mechanisms inform disease states.

My work combines whole-genome functional genomics experiments, such as ChIP-seq and RNA-seq, with computational comparison of genome sequences across species (comparative genomics) to study the evolution of gene regulation in mammals. Using this approach, I have recently characterised the patterns of evolution in promoter and enhancer activity across placental mammals. My current interests include elucidation of (i) how evolutionary stability of regulatory regions associates with downstream gene expression, (ii) mechanisms of tissue-specific regulatory evolution and (iii) regulatory adaptations in mammals.

Work address: 

Cancer Research UK Cambridge Institute
University of Cambridge
Li Ka Shing Centre
Robinson Way
Cambridge CB2 0RE

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