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Cancer Research UK Cambridge Institute

Senior Research Associate


I started my research training with a masters degree in immunology in Germany before heading to the University of Chicago to do a PhD with Dr. Marcus Peter studying signal transduction in apoptosis. I then chose to return to immunology (and Europe) for a postdoc at the Cambridge Research Institute under the mentorship of Profs. David Tuveson and Douglas Fearon.  We discovered that the stromal fibroblasts in pancreatic cancer exert a strong immunosuppression and that it can be overcome therapeutically. This approach is currently being tested in clinical trials.  As a staff scientist in Dr. Duncan Odom’s lab I am now using large-scale genomic approaches to uncover molecular rules of liver cancer development.

 

Selected publications

Feig C, Odom DT. Cohesin's role as an active chromatin domain anchorage revealed.  

EMBO J. 2013 Dec 11;32(24):3114

 

Feig C*, Jones JO*, Kraman M*, Wells RJB*, Deonarine A, Chan DS, Connell CM, Roberts EW, Zhao Q, Caballero OL, Teichmann SA, Janowitz T, Jodrell DI, Tuveson DA, Fearon DT. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.

PNAS. 2013 Dec 10;110(50):20212

 

Feig C, Gophinathan A, Neesse A, Chan DS, Cook N, Tuveson DA. The pancreas cancer microenvironment.

Clin Cancer Res. 2012 Aug 15;18(16):4266

 

Chen L, Park SM, Tumanov AV, Hau A, Sawada K, Feig C, Turner JR, Fu YX, Romero I, Lengyel E, Peter ME. CD95 promotes tumour growth.

Nature. 2010 May 27;465(7297):492

 

Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.

Science. 2009 Jun 12;324(5933):1457

 

Feig C, Tchikov V, Schütze S, Peter ME. Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.

EMBO J. 2007 Jan 10;26(1):221


 * equal contribution

 

Email: Name.Surname@cruk.cam.ac.uk

 

Work address: 

Cancer Research UK Cambridge Institute
University of Cambridge
Li Ka Shing Centre
Robinson Way
Cambridge CB2 0RE

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