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Cancer Research UK Cambridge Institute



Our aim is to facilitate translational research by providing a centralised Hub for the innovation, application and use of state-of-the-art Genome Editing (GE) technologies.

Our facility works in unison with the world-class Research Groups at the CRUK CI, and the outstanding Core facilities, to work towards truly ground breaking research and meaningful clinical impact.

The cutting edge of Genome Editing

There is a revolution in the field of molecular biology that is a complete game changer. With the advent of the CRISPR-Cas9 technology in 2012, Genome Editing (GE) has become simpler, cheaper and much faster than ever before. Researchers are now reinventing the way we do genetic research, being able to ask more complex and more relevant questions of biology.

Our facility aims to be at the forefront of this revolution, specialising in CRISPR-Cas9 technology (as well as more established GE technologies such as viral-based GE tools). We serve as a centralised portal for the innovation, design, construction, validation, curation and housing of GE tools and resources within the CRUK CI. Furthermore, our scientists have decades of experience at applying GE technologies to a very broad range of complex, patient-relevant model systems; and of the use of these GE resources in pre-clinical experimental programmes.

With a focus on education, we see our role as empowering Research Groups by bringing together industry and academic experts in the respective technologies, thus enabling effective knowledge exchange and network building.

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